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@ARTICLE{Khodosevich:137225,
      author       = {Khodosevich, Konstantin and Lazarini, Françoise and
                      Engelhardt, Jakob and Kaneko, Hiroshi and Lledo,
                      Pierre-Marie and Monyer, Hannah},
      title        = {{C}onnective tissue growth factor regulates interneuron
                      survival and information processing in the olfactory bulb.},
      journal      = {Neuron},
      volume       = {79},
      number       = {6},
      issn         = {0896-6273},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-03547},
      pages        = {1136-1151},
      year         = {2013},
      abstract     = {Neurogenesis underlies plastic changes in defined neuronal
                      circuits in the postnatal and adult brain. Here we identify
                      connective tissue growth factor (CTGF) as a critical factor
                      in the mouse olfactory bulb (OB) in determining the
                      efficiency of incorporation of postnatally born inhibitory
                      neurons, thus gating the output of glomeruli, the first
                      relay station of olfactory processing in the brain. In the
                      OB, CTGF expression was restricted to prenatally born
                      external tufted cells. CTGF enhanced the proapoptotic
                      activity of glial-derived TGF-β2, decreasing the survival
                      of periglomerular inhibitory neurons. Changes in CTGF
                      expression levels in the OB led to modifications in local
                      neuronal circuitry and olfactory behaviors. We show that the
                      odorant-specific recruitment of distinct glomeruli resulted
                      in enhanced local CTGF expression levels in the activated
                      glomeruli. Collectively our data reveal a molecular
                      mechanism controlling the survival of defined postnatally
                      born neurons, thus adapting neuronal integration to the
                      sensory experiences.},
      keywords     = {Analysis of Variance / Animals / Animals, Newborn /
                      Bromodeoxyuridine: metabolism / Cell Line, Transformed /
                      Cell Survival: genetics / Connective Tissue Growth Factor:
                      genetics / Connective Tissue Growth Factor: metabolism /
                      Discrimination, Psychological: physiology / Female / Gene
                      Expression Regulation: genetics / Humans / Interneurons:
                      physiology / Luminescent Proteins: genetics / Luminescent
                      Proteins: metabolism / Lysine: analogs $\&$ derivatives /
                      Lysine: metabolism / Male / Memory, Long-Term: physiology /
                      Mice / Mice, Inbred C57BL / Mice, Transgenic / MicroRNAs:
                      genetics / MicroRNAs: metabolism / Nerve Tissue Proteins:
                      genetics / Nerve Tissue Proteins: metabolism / Odorants /
                      Olfactory Bulb: cytology / Olfactory Bulb: physiology /
                      Organ Culture Techniques / Protein-Serine-Threonine Kinases:
                      genetics / RNA, Small Interfering: genetics / RNA, Small
                      Interfering: metabolism / Receptor, Transforming Growth
                      Factor-beta Type II / Receptors, Odorant: genetics /
                      Receptors, Odorant: metabolism / Receptors, Transforming
                      Growth Factor beta: genetics / Sensory Thresholds:
                      physiology / Smell: genetics / Synaptic Potentials: genetics
                      / Transfection / tau Proteins: genetics / Luminescent
                      Proteins (NLM Chemicals) / MicroRNAs (NLM Chemicals) / Nerve
                      Tissue Proteins (NLM Chemicals) / Olfr16 protein, mouse (NLM
                      Chemicals) / RNA, Small Interfering (NLM Chemicals) /
                      Receptors, Odorant (NLM Chemicals) / Receptors, Transforming
                      Growth Factor beta (NLM Chemicals) / tau Proteins (NLM
                      Chemicals) / Connective Tissue Growth Factor (NLM Chemicals)
                      / Protein-Serine-Threonine Kinases (NLM Chemicals) /
                      Receptor, Transforming Growth Factor-beta Type II (NLM
                      Chemicals) / Bromodeoxyuridine (NLM Chemicals) / biocytin
                      (NLM Chemicals) / Lysine (NLM Chemicals)},
      cin          = {AG Engelhardt},
      ddc          = {610},
      cid          = {I:(DE-2719)1013023},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23993699},
      doi          = {10.1016/j.neuron.2013.07.011},
      url          = {https://pub.dzne.de/record/137225},
}