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001     137225
005     20240321220219.0
024 7 _ |a 10.1016/j.neuron.2013.07.011
|2 doi
024 7 _ |a pmid:23993699
|2 pmid
024 7 _ |a 0896-6273
|2 ISSN
024 7 _ |a 1097-4199
|2 ISSN
024 7 _ |a altmetric:1718647
|2 altmetric
037 _ _ |a DZNE-2020-03547
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Khodosevich, Konstantin
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb.
260 _ _ |a New York, NY
|c 2013
|b Elsevier
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2013-09-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1710769665_18974
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Neurogenesis underlies plastic changes in defined neuronal circuits in the postnatal and adult brain. Here we identify connective tissue growth factor (CTGF) as a critical factor in the mouse olfactory bulb (OB) in determining the efficiency of incorporation of postnatally born inhibitory neurons, thus gating the output of glomeruli, the first relay station of olfactory processing in the brain. In the OB, CTGF expression was restricted to prenatally born external tufted cells. CTGF enhanced the proapoptotic activity of glial-derived TGF-β2, decreasing the survival of periglomerular inhibitory neurons. Changes in CTGF expression levels in the OB led to modifications in local neuronal circuitry and olfactory behaviors. We show that the odorant-specific recruitment of distinct glomeruli resulted in enhanced local CTGF expression levels in the activated glomeruli. Collectively our data reveal a molecular mechanism controlling the survival of defined postnatally born neurons, thus adapting neuronal integration to the sensory experiences.
536 _ _ |a 341 - Molecular Signaling (POF3-341)
|0 G:(DE-HGF)POF3-341
|c POF3-341
|f POF III
|x 0
542 _ _ |i 2013-09-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2014-09-18
|2 Crossref
|u https://www.elsevier.com/open-access/userlicense/1.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Luminescent Proteins
|2 NLM Chemicals
650 _ 7 |a MicroRNAs
|2 NLM Chemicals
650 _ 7 |a Nerve Tissue Proteins
|2 NLM Chemicals
650 _ 7 |a Olfr16 protein, mouse
|2 NLM Chemicals
650 _ 7 |a RNA, Small Interfering
|2 NLM Chemicals
650 _ 7 |a Receptors, Odorant
|2 NLM Chemicals
650 _ 7 |a Receptors, Transforming Growth Factor beta
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 7 |a Connective Tissue Growth Factor
|0 139568-91-5
|2 NLM Chemicals
650 _ 7 |a Protein-Serine-Threonine Kinases
|0 EC 2.7.11.1
|2 NLM Chemicals
650 _ 7 |a Receptor, Transforming Growth Factor-beta Type II
|0 EC 2.7.11.30
|2 NLM Chemicals
650 _ 7 |a Bromodeoxyuridine
|0 G34N38R2N1
|2 NLM Chemicals
650 _ 7 |a biocytin
|0 G6D6147J22
|2 NLM Chemicals
650 _ 7 |a Lysine
|0 K3Z4F929H6
|2 NLM Chemicals
650 _ 2 |a Analysis of Variance
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Animals, Newborn
|2 MeSH
650 _ 2 |a Bromodeoxyuridine: metabolism
|2 MeSH
650 _ 2 |a Cell Line, Transformed
|2 MeSH
650 _ 2 |a Cell Survival: genetics
|2 MeSH
650 _ 2 |a Connective Tissue Growth Factor: genetics
|2 MeSH
650 _ 2 |a Connective Tissue Growth Factor: metabolism
|2 MeSH
650 _ 2 |a Discrimination, Psychological: physiology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Gene Expression Regulation: genetics
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Interneurons: physiology
|2 MeSH
650 _ 2 |a Luminescent Proteins: genetics
|2 MeSH
650 _ 2 |a Luminescent Proteins: metabolism
|2 MeSH
650 _ 2 |a Lysine: analogs & derivatives
|2 MeSH
650 _ 2 |a Lysine: metabolism
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Memory, Long-Term: physiology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a MicroRNAs: genetics
|2 MeSH
650 _ 2 |a MicroRNAs: metabolism
|2 MeSH
650 _ 2 |a Nerve Tissue Proteins: genetics
|2 MeSH
650 _ 2 |a Nerve Tissue Proteins: metabolism
|2 MeSH
650 _ 2 |a Odorants
|2 MeSH
650 _ 2 |a Olfactory Bulb: cytology
|2 MeSH
650 _ 2 |a Olfactory Bulb: physiology
|2 MeSH
650 _ 2 |a Organ Culture Techniques
|2 MeSH
650 _ 2 |a Protein-Serine-Threonine Kinases: genetics
|2 MeSH
650 _ 2 |a RNA, Small Interfering: genetics
|2 MeSH
650 _ 2 |a RNA, Small Interfering: metabolism
|2 MeSH
650 _ 2 |a Receptor, Transforming Growth Factor-beta Type II
|2 MeSH
650 _ 2 |a Receptors, Odorant: genetics
|2 MeSH
650 _ 2 |a Receptors, Odorant: metabolism
|2 MeSH
650 _ 2 |a Receptors, Transforming Growth Factor beta: genetics
|2 MeSH
650 _ 2 |a Sensory Thresholds: physiology
|2 MeSH
650 _ 2 |a Smell: genetics
|2 MeSH
650 _ 2 |a Synaptic Potentials: genetics
|2 MeSH
650 _ 2 |a Transfection
|2 MeSH
650 _ 2 |a tau Proteins: genetics
|2 MeSH
700 1 _ |a Lazarini, Françoise
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Engelhardt, Jakob
|0 P:(DE-2719)2810460
|b 2
|u dzne
700 1 _ |a Kaneko, Hiroshi
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Lledo, Pierre-Marie
|0 P:(DE-HGF)0
|b 4
700 1 _ |a Monyer, Hannah
|0 P:(DE-HGF)0
|b 5
|e Corresponding author
773 1 8 |a 10.1016/j.neuron.2013.07.011
|b : Elsevier BV, 2013-09-01
|n 6
|p 1136-1151
|3 journal-article
|2 Crossref
|t Neuron
|v 79
|y 2013
|x 0896-6273
773 _ _ |a 10.1016/j.neuron.2013.07.011
|g Vol. 79, no. 6, p. 1136 - 1151
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856 4 _ |u https://pub.dzne.de/record/137225/files/DZNE-2020-03547_Restricted.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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