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000137393 0247_ $$2doi$$a10.1212/WNL.0000000000000271
000137393 0247_ $$2pmid$$apmid:24574548
000137393 0247_ $$2ISSN$$a0028-3878
000137393 0247_ $$2ISSN$$a1526-632X
000137393 0247_ $$2altmetric$$aaltmetric:2230983
000137393 037__ $$aDZNE-2020-03715
000137393 041__ $$aEnglish
000137393 082__ $$a610
000137393 1001_ $$0P:(DE-HGF)0$$aSajjadi, Seyed Ahmad$$b0
000137393 245__ $$aLogopenic, mixed, or Alzheimer-related aphasia?
000137393 260__ $$a[S.l.]$$bOvid$$c2014
000137393 264_1 $$2Crossref$$3online$$bOvid Technologies (Wolters Kluwer Health)$$c2014-02-26
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000137393 520__ $$aThis study tested the hypothesis that patients with primary progressive aphasia (PPA) who do not meet the proposed criteria for any of the recognized subtypes would have the atrophy pattern reported in the past for logopenic variant PPA (lvPPA), in turn suggesting that the PPA of likely Alzheimer disease origin is more variable than that captured in the current lvPPA diagnostic recommendations.MRI gray matter volumes from 14 patients with mixed PPA who failed to meet the diagnostic recommendations for any recognized variant were compared with those of 25 matched control participants via voxel-based morphometry.The mixed PPA group had left temporoparietal atrophy with a pattern identical to that in previously reported lvPPA cohorts.Patients with PPA who did not meet the criteria for any recognized PPA variant at their initial assessment had the group-level atrophy pattern previously reported as the hallmark of lvPPA. We suggest that the specific language features proposed for lvPPA are too narrow to characterize the language impairments arising from likely Alzheimer pathology.
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000137393 650_2 $$2MeSH$$aAged
000137393 650_2 $$2MeSH$$aAged, 80 and over
000137393 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000137393 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000137393 650_2 $$2MeSH$$aAphasia, Primary Progressive: diagnosis
000137393 650_2 $$2MeSH$$aAphasia, Primary Progressive: psychology
000137393 650_2 $$2MeSH$$aFemale
000137393 650_2 $$2MeSH$$aHumans
000137393 650_2 $$2MeSH$$aLanguage Tests: standards
000137393 650_2 $$2MeSH$$aMagnetic Resonance Imaging: standards
000137393 650_2 $$2MeSH$$aMale
000137393 650_2 $$2MeSH$$aMiddle Aged
000137393 650_2 $$2MeSH$$aNeuropsychological Tests: standards
000137393 7001_ $$0P:(DE-HGF)0$$aPatterson, Karalyn$$b1
000137393 7001_ $$0P:(DE-2719)2810673$$aNestor, Peter John$$b2$$eLast author
000137393 77318 $$2Crossref$$3journal-article$$a10.1212/wnl.0000000000000271$$b : Ovid Technologies (Wolters Kluwer Health), 2014-02-26$$n13$$p1127-1131$$tNeurology$$v82$$x0028-3878$$y2014
000137393 773__ $$0PERI:(DE-600)1491874-2$$a10.1212/WNL.0000000000000271$$gVol. 82, no. 13, p. 1127 - 1131$$n13$$p1127-1131$$q82:13<1127 - 1131$$tNeurology$$v82$$x0028-3878$$y2014
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