Journal Article

DZNE-2020-03715

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Logopenic, mixed, or Alzheimer-related aphasia?

Sajjadi, S. A. ; Patterson, K. ; Nestor, P. J. (Last author)DZNE*

2014
Ovid [S.l.]

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Please use a persistent id in citations: doi:10.1212/WNL.0000000000000271

Abstract: This study tested the hypothesis that patients with primary progressive aphasia (PPA) who do not meet the proposed criteria for any of the recognized subtypes would have the atrophy pattern reported in the past for logopenic variant PPA (lvPPA), in turn suggesting that the PPA of likely Alzheimer disease origin is more variable than that captured in the current lvPPA diagnostic recommendations.MRI gray matter volumes from 14 patients with mixed PPA who failed to meet the diagnostic recommendations for any recognized variant were compared with those of 25 matched control participants via voxel-based morphometry.The mixed PPA group had left temporoparietal atrophy with a pattern identical to that in previously reported lvPPA cohorts.Patients with PPA who did not meet the criteria for any recognized PPA variant at their initial assessment had the group-level atrophy pattern previously reported as the hallmark of lvPPA. We suggest that the specific language features proposed for lvPPA are too narrow to characterize the language impairments arising from likely Alzheimer pathology.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Alzheimer Disease: psychology (MeSH) ; Aphasia, Primary Progressive: diagnosis (MeSH) ; Aphasia, Primary Progressive: psychology (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Language Tests: standards (MeSH) ; Magnetic Resonance Imaging: standards (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Neuropsychological Tests: standards (MeSH)

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Contributing Institute(s):

1. Cognitive Neurology and Neurodegeneration (AG Nestor)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2014

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Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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