TY  - JOUR
AU  - Sajjadi, Seyed Ahmad
AU  - Patterson, Karalyn
AU  - Nestor, Peter John
TI  - Logopenic, mixed, or Alzheimer-related aphasia?
JO  - Neurology
VL  - 82
IS  - 13
SN  - 0028-3878
CY  - [S.l.]
PB  - Ovid
M1  - DZNE-2020-03715
SP  - 1127-1131
PY  - 2014
AB  - This study tested the hypothesis that patients with primary progressive aphasia (PPA) who do not meet the proposed criteria for any of the recognized subtypes would have the atrophy pattern reported in the past for logopenic variant PPA (lvPPA), in turn suggesting that the PPA of likely Alzheimer disease origin is more variable than that captured in the current lvPPA diagnostic recommendations.MRI gray matter volumes from 14 patients with mixed PPA who failed to meet the diagnostic recommendations for any recognized variant were compared with those of 25 matched control participants via voxel-based morphometry.The mixed PPA group had left temporoparietal atrophy with a pattern identical to that in previously reported lvPPA cohorts.Patients with PPA who did not meet the criteria for any recognized PPA variant at their initial assessment had the group-level atrophy pattern previously reported as the hallmark of lvPPA. We suggest that the specific language features proposed for lvPPA are too narrow to characterize the language impairments arising from likely Alzheimer pathology.
KW  - Aged
KW  - Aged, 80 and over
KW  - Alzheimer Disease: diagnosis
KW  - Alzheimer Disease: psychology
KW  - Aphasia, Primary Progressive: diagnosis
KW  - Aphasia, Primary Progressive: psychology
KW  - Female
KW  - Humans
KW  - Language Tests: standards
KW  - Magnetic Resonance Imaging: standards
KW  - Male
KW  - Middle Aged
KW  - Neuropsychological Tests: standards
LB  - PUB:(DE-HGF)16
C6  - pmid:24574548
DO  - DOI:10.1212/WNL.0000000000000271
UR  - https://pub.dzne.de/record/137393
ER  -