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| 001 | 137534 | ||
| 005 | 20240321220252.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jalz.2013.03.010 |2 doi |
| 024 | 7 | _ | |a pmid:23978325 |2 pmid |
| 024 | 7 | _ | |a 1552-5260 |2 ISSN |
| 024 | 7 | _ | |a 1552-5279 |2 ISSN |
| 024 | 7 | _ | |a altmetric:1873751 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-03856 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Vijayaraghavan, Swetha |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2014 |b Elsevier |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2013-08-26 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2014-09-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1709029930_12962 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Apolipoprotein E ε4 allele (APOE ε4) increases the apolipoprotein E (apoE) protein levels in Alzheimer's disease (AD) cerebrospinal fluid (CSF). Thus, we hypothesized that apoE levels were also associated with the APOE genotype, and amyloid-β (Aβ)-associated clinical, functional, and imaging parameters in patients with Lewy body-associated disorders (LBD). Indeed, similar to AD, patients with LBD displayed high CSF apoE levels (greatest in patients with dementia with LBD), and this was linked to APOE ε4. High CSF apoE protein correlated positively with CSF soluble amyloid precursor protein, total tau, and cortical and striatal Pittsburgh compound B retention; and correlated negatively with CSF Aβ42, cognitive tests scores, and glucose uptake ratio in the temporal and parietal cortices. APOE ε4-triggered accumulation of apoE in CSF is related to Aβ-associated clinical and functional imaging parameters in LBD. Accordingly, therapeutic strategies aimed at reducing apoE levels in the brain should be explored not only in AD but also in LBD, particularly when accompanied with dementia. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 536 | _ | _ | |a 345 - Population Studies and Genetics (POF3-345) |0 G:(DE-HGF)POF3-345 |c POF3-345 |f POF III |x 1 |
| 542 | _ | _ | |i 2013-08-26 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 542 | _ | _ | |i 2013-08-26 |2 Crossref |u http://onlinelibrary.wiley.com/termsAndConditions#vor |
| 542 | _ | _ | |i 2013-08-26 |2 Crossref |u https://www.elsevier.com/tdm/userlicense/1.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole |2 NLM Chemicals |
| 650 | _ | 7 | |a APP protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Amyloid beta-Peptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Amyloid beta-Protein Precursor |2 NLM Chemicals |
| 650 | _ | 7 | |a Aniline Compounds |2 NLM Chemicals |
| 650 | _ | 7 | |a Apolipoproteins E |2 NLM Chemicals |
| 650 | _ | 7 | |a Biomarkers |2 NLM Chemicals |
| 650 | _ | 7 | |a Carbon Radioisotopes |2 NLM Chemicals |
| 650 | _ | 7 | |a MAPT protein, human |2 NLM Chemicals |
| 650 | _ | 7 | |a Peptide Fragments |2 NLM Chemicals |
| 650 | _ | 7 | |a Radiopharmaceuticals |2 NLM Chemicals |
| 650 | _ | 7 | |a Thiazoles |2 NLM Chemicals |
| 650 | _ | 7 | |a amyloid beta-protein (1-42) |2 NLM Chemicals |
| 650 | _ | 7 | |a tau Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Fluorodeoxyglucose F18 |0 0Z5B2CJX4D |2 NLM Chemicals |
| 650 | _ | 7 | |a Glucose |0 IY9XDZ35W2 |2 NLM Chemicals |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Aged, 80 and over |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Protein Precursor: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Aniline Compounds |2 MeSH |
| 650 | _ | 2 | |a Apolipoproteins E: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Apolipoproteins E: genetics |2 MeSH |
| 650 | _ | 2 | |a Biomarkers: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Brain: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Brain: metabolism |2 MeSH |
| 650 | _ | 2 | |a Brain: pathology |2 MeSH |
| 650 | _ | 2 | |a Carbon Radioisotopes |2 MeSH |
| 650 | _ | 2 | |a Cohort Studies |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Fluorodeoxyglucose F18 |2 MeSH |
| 650 | _ | 2 | |a Glucose: metabolism |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Lewy Body Disease: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Lewy Body Disease: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Lewy Body Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Lewy Body Disease: psychology |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Neuropsychological Tests |2 MeSH |
| 650 | _ | 2 | |a Peptide Fragments: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Positron-Emission Tomography |2 MeSH |
| 650 | _ | 2 | |a Radiopharmaceuticals |2 MeSH |
| 650 | _ | 2 | |a Thiazoles |2 MeSH |
| 650 | _ | 2 | |a tau Proteins: cerebrospinal fluid |2 MeSH |
| 700 | 1 | _ | |a Maetzler, Walter |0 P:(DE-2719)2810915 |b 1 |u dzne |
| 700 | 1 | _ | |a Reimold, Matthias |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Lithner, Christina Unger |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Liepelt-Scarfone, Inga |0 P:(DE-2719)2109499 |b 4 |u dzne |
| 700 | 1 | _ | |a Berg, Daniela |0 P:(DE-2719)2000059 |b 5 |u dzne |
| 700 | 1 | _ | |a Darreh-Shori, Taher |0 P:(DE-HGF)0 |b 6 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1016/j.jalz.2013.03.010 |b : Wiley, 2013-08-26 |n 5 |p 530-540.e1 |3 journal-article |2 Crossref |t Alzheimer's & Dementia |v 10 |y 2013 |x 1552-5260 |
| 773 | _ | _ | |a 10.1016/j.jalz.2013.03.010 |g Vol. 10, no. 5, p. 530 - 540.e1 |0 PERI:(DE-600)2201940-6 |n 5 |q 10:5<530 - 540.e1 |p 530-540.e1 |t Alzheimer's and dementia |v 10 |y 2014 |x 1552-5260 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/137534/files/DZNE-2020-03856_Restricted.pdf |
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| 914 | 1 | _ | |y 2014 |
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| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ALZHEIMERS DEMENT : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
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| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |
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