Journal Article

DZNE-2020-03856

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia.

Vijayaraghavan, S. ; Maetzler, W.DZNE* ; Reimold, M. ; Lithner, C. U. ; Liepelt-Scarfone, I.DZNE* ; Berg, D.DZNE* ; Darreh-Shori, T. (Corresponding author)

2014
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jalz.2013.03.010

Abstract: Apolipoprotein E ε4 allele (APOE ε4) increases the apolipoprotein E (apoE) protein levels in Alzheimer's disease (AD) cerebrospinal fluid (CSF). Thus, we hypothesized that apoE levels were also associated with the APOE genotype, and amyloid-β (Aβ)-associated clinical, functional, and imaging parameters in patients with Lewy body-associated disorders (LBD). Indeed, similar to AD, patients with LBD displayed high CSF apoE levels (greatest in patients with dementia with LBD), and this was linked to APOE ε4. High CSF apoE protein correlated positively with CSF soluble amyloid precursor protein, total tau, and cortical and striatal Pittsburgh compound B retention; and correlated negatively with CSF Aβ42, cognitive tests scores, and glucose uptake ratio in the temporal and parietal cortices. APOE ε4-triggered accumulation of apoE in CSF is related to Aβ-associated clinical and functional imaging parameters in LBD. Accordingly, therapeutic strategies aimed at reducing apoE levels in the brain should be explored not only in AD but also in LBD, particularly when accompanied with dementia.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Amyloid beta-Peptides: cerebrospinal fluid (MeSH) ; Amyloid beta-Protein Precursor: cerebrospinal fluid (MeSH) ; Aniline Compounds (MeSH) ; Apolipoproteins E: cerebrospinal fluid (MeSH) ; Apolipoproteins E: genetics (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: metabolism (MeSH) ; Brain: pathology (MeSH) ; Carbon Radioisotopes (MeSH) ; Cohort Studies (MeSH) ; Female (MeSH) ; Fluorodeoxyglucose F18 (MeSH) ; Glucose: metabolism (MeSH) ; Humans (MeSH) ; Lewy Body Disease: cerebrospinal fluid (MeSH) ; Lewy Body Disease: diagnostic imaging (MeSH) ; Lewy Body Disease: genetics (MeSH) ; Lewy Body Disease: psychology (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Neuropsychological Tests (MeSH) ; Peptide Fragments: cerebrospinal fluid (MeSH) ; Positron-Emission Tomography (MeSH) ; Radiopharmaceuticals (MeSH) ; Thiazoles (MeSH) ; tau Proteins: cerebrospinal fluid (MeSH) ; 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole ; APP protein, human ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Aniline Compounds ; Apolipoproteins E ; Biomarkers ; Carbon Radioisotopes ; MAPT protein, human ; Peptide Fragments ; Radiopharmaceuticals ; Thiazoles ; amyloid beta-protein (1-42) ; tau Proteins ; Fluorodeoxyglucose F18 ; Glucose

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Contributing Institute(s):

1. Functional Neurogeriatrics (AG Maetzler)
2. Parkinson Genetics (AG Gasser)
3. Parkinson's Disease Genetics (AG Berg ; AG Berg)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2014

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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