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000137535 0247_ $$2doi$$a10.1016/j.physbeh.2014.05.041
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000137535 041__ $$aEnglish
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000137535 1001_ $$0P:(DE-2719)2810406$$aSchneider, F.$$b0$$eFirst author$$udzne
000137535 245__ $$aBehavioral and EEG changes in male 5xFAD mice.
000137535 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2014
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000137535 520__ $$aTransgenic animal models of Alzheimer's disease (AD) are widely used to investigate mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early development of parenchymal plaque load at the age of 2months is the 5xFAD mouse (Tg6799, Oakley et al. 2006). These 5xFAD mice over-express both human amyloid precursor protein (APP) and human presenilin 1 (PS1). Mice from this line have a high APP expression correlating with a high burden and an accelerated accumulation of the 42 amino acid species of amyloid-β (Aβ). The aim of this study was the behavioral and functional investigations of 5xFAD males because in most studies females of this strain were characterized. In comparison to literature of transgenic 5xFAD females, transgenic 5xFAD males showed decreased anxiety in the elevated plus maze, reduced locomotion and exploration in the open field and disturbances in learning performance in the Morris water maze starting at 9months of age. Electroencephalogram (EEG) recordings on 6month old transgenic mice revealed a decrease of delta, theta, alpha, beta and gamma frequency bands whereas the subdelta frequency was increased. EEG recordings during sleep showed a reduction of rapid eye movement sleep in relation to the amount of total sleep. Thus, 5xFAD males develop early functional disturbances and subsequently behavioral deficits and therefore they are a good mouse model for studying Alzheimer's disease.
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000137535 650_7 $$2NLM Chemicals$$aAmyloid beta-Protein Precursor
000137535 650_7 $$2NLM Chemicals$$aPSEN1 protein, human
000137535 650_7 $$2NLM Chemicals$$aPresenilin-1
000137535 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000137535 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000137535 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000137535 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: genetics
000137535 650_2 $$2MeSH$$aAnimals
000137535 650_2 $$2MeSH$$aAnxiety: genetics
000137535 650_2 $$2MeSH$$aAnxiety: physiopathology
000137535 650_2 $$2MeSH$$aAnxiety: psychology
000137535 650_2 $$2MeSH$$aBehavior, Animal: physiology
000137535 650_2 $$2MeSH$$aBrain: physiopathology
000137535 650_2 $$2MeSH$$aDisease Models, Animal
000137535 650_2 $$2MeSH$$aElectroencephalography
000137535 650_2 $$2MeSH$$aExploratory Behavior: physiology
000137535 650_2 $$2MeSH$$aMale
000137535 650_2 $$2MeSH$$aMaze Learning: physiology
000137535 650_2 $$2MeSH$$aMice
000137535 650_2 $$2MeSH$$aMice, Transgenic
000137535 650_2 $$2MeSH$$aPresenilin-1: genetics
000137535 650_2 $$2MeSH$$aSleep: physiology
000137535 7001_ $$0P:(DE-2719)2239681$$aBaldauf, K.$$b1$$eCorresponding author$$udzne
000137535 7001_ $$0P:(DE-HGF)0$$aWetzel, W.$$b2
000137535 7001_ $$0P:(DE-2719)2740485$$aReymann, Klaus$$b3$$eLast author$$udzne
000137535 77318 $$2Crossref$$3journal-article$$a10.1016/j.physbeh.2014.05.041$$b : Elsevier BV, 2014-08-01$$p25-33$$tPhysiology & Behavior$$v135$$x0031-9384$$y2014
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