Journal Article

DZNE-2020-03857

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Behavioral and EEG changes in male 5xFAD mice.

Schneider, F. (First author)DZNE* ; Baldauf, K. (Corresponding author)DZNE* ; Wetzel, W. ; Reymann, K. (Last author)DZNE*

2014
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.physbeh.2014.05.041

Abstract: Transgenic animal models of Alzheimer's disease (AD) are widely used to investigate mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early development of parenchymal plaque load at the age of 2months is the 5xFAD mouse (Tg6799, Oakley et al. 2006). These 5xFAD mice over-express both human amyloid precursor protein (APP) and human presenilin 1 (PS1). Mice from this line have a high APP expression correlating with a high burden and an accelerated accumulation of the 42 amino acid species of amyloid-β (Aβ). The aim of this study was the behavioral and functional investigations of 5xFAD males because in most studies females of this strain were characterized. In comparison to literature of transgenic 5xFAD females, transgenic 5xFAD males showed decreased anxiety in the elevated plus maze, reduced locomotion and exploration in the open field and disturbances in learning performance in the Morris water maze starting at 9months of age. Electroencephalogram (EEG) recordings on 6month old transgenic mice revealed a decrease of delta, theta, alpha, beta and gamma frequency bands whereas the subdelta frequency was increased. EEG recordings during sleep showed a reduction of rapid eye movement sleep in relation to the amount of total sleep. Thus, 5xFAD males develop early functional disturbances and subsequently behavioral deficits and therefore they are a good mouse model for studying Alzheimer's disease.

Keyword(s): Alzheimer Disease: genetics (MeSH) ; Alzheimer Disease: physiopathology (MeSH) ; Alzheimer Disease: psychology (MeSH) ; Amyloid beta-Protein Precursor: genetics (MeSH) ; Animals (MeSH) ; Anxiety: genetics (MeSH) ; Anxiety: physiopathology (MeSH) ; Anxiety: psychology (MeSH) ; Behavior, Animal: physiology (MeSH) ; Brain: physiopathology (MeSH) ; Disease Models, Animal (MeSH) ; Electroencephalography (MeSH) ; Exploratory Behavior: physiology (MeSH) ; Male (MeSH) ; Maze Learning: physiology (MeSH) ; Mice (MeSH) ; Mice, Transgenic (MeSH) ; Presenilin-1: genetics (MeSH) ; Sleep: physiology (MeSH) ; Amyloid beta-Protein Precursor ; PSEN1 protein, human ; Presenilin-1

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Contributing Institute(s):

1. Pathophysiology of Dementia (AG Reymann)
2. Core MR PET (Core MR PET)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2014

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection ; Zoological Record

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