TY  - JOUR
AU  - Schneider, F.
AU  - Baldauf, K.
AU  - Wetzel, W.
AU  - Reymann, Klaus
TI  - Behavioral and EEG changes in male 5xFAD mice.
JO  - Physiology & behavior
VL  - 135
SN  - 0031-9384
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-03857
SP  - 25-33
PY  - 2014
AB  - Transgenic animal models of Alzheimer's disease (AD) are widely used to investigate mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early development of parenchymal plaque load at the age of 2months is the 5xFAD mouse (Tg6799, Oakley et al. 2006). These 5xFAD mice over-express both human amyloid precursor protein (APP) and human presenilin 1 (PS1). Mice from this line have a high APP expression correlating with a high burden and an accelerated accumulation of the 42 amino acid species of amyloid-β (Aβ). The aim of this study was the behavioral and functional investigations of 5xFAD males because in most studies females of this strain were characterized. In comparison to literature of transgenic 5xFAD females, transgenic 5xFAD males showed decreased anxiety in the elevated plus maze, reduced locomotion and exploration in the open field and disturbances in learning performance in the Morris water maze starting at 9months of age. Electroencephalogram (EEG) recordings on 6month old transgenic mice revealed a decrease of delta, theta, alpha, beta and gamma frequency bands whereas the subdelta frequency was increased. EEG recordings during sleep showed a reduction of rapid eye movement sleep in relation to the amount of total sleep. Thus, 5xFAD males develop early functional disturbances and subsequently behavioral deficits and therefore they are a good mouse model for studying Alzheimer's disease.
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: physiopathology
KW  - Alzheimer Disease: psychology
KW  - Amyloid beta-Protein Precursor: genetics
KW  - Animals
KW  - Anxiety: genetics
KW  - Anxiety: physiopathology
KW  - Anxiety: psychology
KW  - Behavior, Animal: physiology
KW  - Brain: physiopathology
KW  - Disease Models, Animal
KW  - Electroencephalography
KW  - Exploratory Behavior: physiology
KW  - Male
KW  - Maze Learning: physiology
KW  - Mice
KW  - Mice, Transgenic
KW  - Presenilin-1: genetics
KW  - Sleep: physiology
KW  - Amyloid beta-Protein Precursor (NLM Chemicals)
KW  - PSEN1 protein, human (NLM Chemicals)
KW  - Presenilin-1 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:24907698
DO  - DOI:10.1016/j.physbeh.2014.05.041
UR  - https://pub.dzne.de/record/137535
ER  -