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@ARTICLE{Schneider:137535,
      author       = {Schneider, F. and Baldauf, K. and Wetzel, W. and Reymann,
                      Klaus},
      title        = {{B}ehavioral and {EEG} changes in male 5x{FAD} mice.},
      journal      = {Physiology $\&$ behavior},
      volume       = {135},
      issn         = {0031-9384},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-03857},
      pages        = {25-33},
      year         = {2014},
      abstract     = {Transgenic animal models of Alzheimer's disease (AD) are
                      widely used to investigate mechanisms of pathophysiology and
                      cognitive dysfunctions. A model with a very early
                      development of parenchymal plaque load at the age of 2months
                      is the 5xFAD mouse (Tg6799, Oakley et al. 2006). These 5xFAD
                      mice over-express both human amyloid precursor protein (APP)
                      and human presenilin 1 (PS1). Mice from this line have a
                      high APP expression correlating with a high burden and an
                      accelerated accumulation of the 42 amino acid species of
                      amyloid-β (Aβ). The aim of this study was the behavioral
                      and functional investigations of 5xFAD males because in most
                      studies females of this strain were characterized. In
                      comparison to literature of transgenic 5xFAD females,
                      transgenic 5xFAD males showed decreased anxiety in the
                      elevated plus maze, reduced locomotion and exploration in
                      the open field and disturbances in learning performance in
                      the Morris water maze starting at 9months of age.
                      Electroencephalogram (EEG) recordings on 6month old
                      transgenic mice revealed a decrease of delta, theta, alpha,
                      beta and gamma frequency bands whereas the subdelta
                      frequency was increased. EEG recordings during sleep showed
                      a reduction of rapid eye movement sleep in relation to the
                      amount of total sleep. Thus, 5xFAD males develop early
                      functional disturbances and subsequently behavioral deficits
                      and therefore they are a good mouse model for studying
                      Alzheimer's disease.},
      keywords     = {Alzheimer Disease: genetics / Alzheimer Disease:
                      physiopathology / Alzheimer Disease: psychology / Amyloid
                      beta-Protein Precursor: genetics / Animals / Anxiety:
                      genetics / Anxiety: physiopathology / Anxiety: psychology /
                      Behavior, Animal: physiology / Brain: physiopathology /
                      Disease Models, Animal / Electroencephalography /
                      Exploratory Behavior: physiology / Male / Maze Learning:
                      physiology / Mice / Mice, Transgenic / Presenilin-1:
                      genetics / Sleep: physiology / Amyloid beta-Protein
                      Precursor (NLM Chemicals) / PSEN1 protein, human (NLM
                      Chemicals) / Presenilin-1 (NLM Chemicals)},
      cin          = {AG Reymann / Core MR PET},
      ddc          = {570},
      cid          = {I:(DE-2719)1310005 / I:(DE-2719)1340016},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24907698},
      doi          = {10.1016/j.physbeh.2014.05.041},
      url          = {https://pub.dzne.de/record/137535},
}