Journal Article

DZNE-2020-03968

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Long-range correlated dynamics in intrinsically disordered proteins.

Parigi, G. ; Rezaei-Ghaleh, N.DZNE* ; Giachetti, A. ; Becker, S. ; Fernandez, C. ; Blackledge, M. ; Griesinger, C. ; Zweckstetter, M. (Corresponding author)DZNE* ; Luchinat, C.

2014
American Chemical Society Washington, DC

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Please use a persistent id in citations: doi:10.1021/ja506820r

Abstract: Intrinsically disordered proteins (IDPs) are involved in a wide variety of physiological and pathological processes and are best described by ensembles of rapidly interconverting conformers. Using fast field cycling relaxation measurements we here show that the IDP α-synuclein as well as a variety of other IDPs undergoes slow reorientations at time scales comparable to folded proteins. The slow motions are not perturbed by mutations in α-synuclein, which are related to genetic forms of Parkinson's disease, and do not depend on secondary and tertiary structural propensities. Ensemble-based hydrodynamic calculations suggest that the time scale of the underlying correlated motion is largely determined by hydrodynamic coupling between locally rigid segments. Our study indicates that long-range correlated dynamics are an intrinsic property of IDPs and offers a general physical mechanism of correlated motions in highly flexible biomolecular systems.

Keyword(s): Animals (MeSH) ; Chemical Phenomena (MeSH) ; Intrinsically Disordered Proteins: chemistry (MeSH) ; Intrinsically Disordered Proteins: genetics (MeSH) ; Intrinsically Disordered Proteins: metabolism (MeSH) ; Models, Molecular (MeSH) ; Mutation (MeSH) ; Protein Conformation (MeSH) ; Protons (MeSH) ; Temperature (MeSH) ; Water: chemistry (MeSH) ; alpha-Synuclein: chemistry (MeSH) ; alpha-Synuclein: genetics (MeSH) ; alpha-Synuclein: metabolism (MeSH) ; Intrinsically Disordered Proteins ; Protons ; alpha-Synuclein ; Water

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Contributing Institute(s):

1. Structural Biology in Dementia (AG Zweckstetter)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2014

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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