Journal Article

DZNE-2020-04147

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Incident subjective memory complaints and the risk of subsequent dementia.

Luck, T. (Corresponding author) ; Luppa, M. ; Matschinger, H. ; Jessen, F.DZNE* ; Angermeyer, M. C. ; Riedel-Heller, S. G.

2015
Blackwell59106 Oxford

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Please use a persistent id in citations: doi:10.1111/acps.12328

Abstract: In this study, we aimed to analyze the association between new-incident-subjective memory complaints (SMC) and risk of subsequent dementia in a general population sample aged 75+ years.Data were derived from follow-up (FUP) waves I-V of the population-based Leipzig Longitudinal Study of the Aged (LEILA75+). We used the Kaplan-Meier survival method to estimate dementia-free survival times of individuals with and without incident SMC and multivariable Cox proportional hazards regression to assess the association between incident SMC and risk of subsequent dementia, controlled for covariates.Of 443 non-demented individuals, 58 (13.1%) developed dementia during a subsequent 5.4-year follow-up period. Participants with incident SMC showed a significantly higher progression to dementia (18.5% vs. 10.0%; P=0.010) and a significantly shorter mean dementia-free survival time than those without (6.2 vs. 6.8 years; P=0.008). The association between incident SMC and risk of subsequent dementia remained significant in the multivariable Cox analysis (adjusted hazard ratio=1.8; P=0.028).Our findings suggest higher progression to dementia and shorter dementia-free survival in older individuals with incident SMC. These findings support the notion that such subjective complaints should be taken seriously in clinical practice as possible early indicators of incipient dementia.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Dementia: diagnosis (MeSH) ; Dementia: epidemiology (MeSH) ; Dementia: etiology (MeSH) ; Disease Progression (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Kaplan-Meier Estimate (MeSH) ; Longitudinal Studies (MeSH) ; Male (MeSH) ; Memory Disorders: complications (MeSH) ; Memory Disorders: diagnosis (MeSH) ; Memory Disorders: epidemiology (MeSH)

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Contributing Institute(s):

1. Patient studies cologne (AG Jessen)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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