Journal Article (Review Article)

DZNE-2020-04331

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lost in translocation: the functions of the 18-kD translocator protein.

Gut, P. ; Zweckstetter, M.DZNE* ; Banati, R. B. (Corresponding author)

2015
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.tem.2015.04.001

Abstract: Research spanning nearly four decades has assigned to the translocator protein (18 kDa) (TSPO) a critical role, among others, in the mitochondrial import of cholesterol, the subsequent steps of (neuro)steroid production, and systemic endocrine regulation, with implications for the pathophysiology of immune, inflammatory, neurodegenerative, and psychiatric as well as neoplastic diseases. Recent knockout studies in mice unexpectedly report normal or latent phenotypes, raising doubts about the protein's role in steroidogenesis and other previously postulated functions and challenging the validity of earlier data on the selectivity of TSPO-binding drugs. Here we provide a synthesis of the current debate from a structural and molecular biology perspective, discuss the limits of inference in loss-of-function (gene knockout) studies, and suggest new functions of TSPO.

Keyword(s): Animals (MeSH) ; Cholesterol: metabolism (MeSH) ; Humans (MeSH) ; Mitochondria: metabolism (MeSH) ; Receptors, GABA: genetics (MeSH) ; Receptors, GABA: metabolism (MeSH) ; Bzrp protein, mouse ; Receptors, GABA ; TSPO protein, human ; Cholesterol

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Contributing Institute(s):

1. Translational Structural Biology (AG Zweckstetter)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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