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000138023 0247_ $$2doi$$a10.1523/JNEUROSCI.4460-14.2015
000138023 0247_ $$2pmid$$apmid:26041909
000138023 0247_ $$2pmc$$apmc:PMC6605336
000138023 0247_ $$2ISSN$$a0270-6474
000138023 0247_ $$2ISSN$$a1529-2401
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000138023 037__ $$aDZNE-2020-04345
000138023 041__ $$aEnglish
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000138023 1001_ $$aDannenberg, Holger$$b0
000138023 245__ $$aSynergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.
000138023 260__ $$aWashington, DC$$bSoc.57413$$c2015
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000138023 520__ $$aThe medial septum/diagonal band of Broca complex (MSDB) is a key structure that modulates hippocampal rhythmogenesis. Cholinergic neurons of the MSDB play a central role in generating and pacing theta-band oscillations in the hippocampal formation during exploration, novelty detection, and memory encoding. How precisely cholinergic neurons affect hippocampal network dynamics in vivo, however, has remained elusive. In this study, we show that stimulation of cholinergic MSDB neurons in urethane-anesthetized mice acts on hippocampal networks via two distinct pathways. A direct septo-hippocampal cholinergic projection causes increased firing of hippocampal inhibitory interneurons with concomitantly decreased firing of principal cells. In addition, cholinergic neurons recruit noncholinergic neurons within the MSDB. This indirect pathway is required for hippocampal theta synchronization. Activation of both pathways causes a reduction in pyramidal neuron firing and a more precise coupling to the theta oscillatory phase. These two anatomically and functionally distinct pathways are likely relevant for cholinergic control of encoding versus retrieval modes in the hippocampus.
000138023 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000138023 542__ $$2Crossref$$i2015-12-03$$uhttps://creativecommons.org/licenses/by-nc-sa/4.0/
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000138023 650_7 $$2NLM Chemicals$$aChannelrhodopsins
000138023 650_7 $$2NLM Chemicals$$aParvalbumins
000138023 650_7 $$0EC 2.3.1.6$$2NLM Chemicals$$aCholine O-Acetyltransferase
000138023 650_7 $$0N9YNS0M02X$$2NLM Chemicals$$aAcetylcholine
000138023 650_2 $$2MeSH$$aAcetylcholine: metabolism
000138023 650_2 $$2MeSH$$aAction Potentials: genetics
000138023 650_2 $$2MeSH$$aAnimals
000138023 650_2 $$2MeSH$$aChannelrhodopsins
000138023 650_2 $$2MeSH$$aCholine O-Acetyltransferase: genetics
000138023 650_2 $$2MeSH$$aCholine O-Acetyltransferase: metabolism
000138023 650_2 $$2MeSH$$aCholinergic Neurons: drug effects
000138023 650_2 $$2MeSH$$aCholinergic Neurons: physiology
000138023 650_2 $$2MeSH$$aDependovirus: genetics
000138023 650_2 $$2MeSH$$aHeart Rate: drug effects
000138023 650_2 $$2MeSH$$aHeart Rate: genetics
000138023 650_2 $$2MeSH$$aHippocampus: cytology
000138023 650_2 $$2MeSH$$aHippocampus: physiology
000138023 650_2 $$2MeSH$$aMice
000138023 650_2 $$2MeSH$$aMice, Transgenic
000138023 650_2 $$2MeSH$$aNeural Pathways: drug effects
000138023 650_2 $$2MeSH$$aNeural Pathways: physiology
000138023 650_2 $$2MeSH$$aNeurons: physiology
000138023 650_2 $$2MeSH$$aParvalbumins: genetics
000138023 650_2 $$2MeSH$$aParvalbumins: metabolism
000138023 650_2 $$2MeSH$$aPhotic Stimulation
000138023 650_2 $$2MeSH$$aPhotoacoustic Techniques
000138023 650_2 $$2MeSH$$aSeptal Nuclei: physiology
000138023 650_2 $$2MeSH$$aTheta Rhythm: genetics
000138023 650_2 $$2MeSH$$aTheta Rhythm: physiology
000138023 650_2 $$2MeSH$$aTime Factors
000138023 650_2 $$2MeSH$$aTransduction, Genetic
000138023 7001_ $$aPabst, Milan$$b1
000138023 7001_ $$aBraganza, Oliver$$b2
000138023 7001_ $$aSchoch, Susanne$$b3
000138023 7001_ $$aNiediek, Johannes$$b4
000138023 7001_ $$aBayraktar, Melike$$b5
000138023 7001_ $$0P:(DE-HGF)0$$aMormann, Florian$$b6
000138023 7001_ $$0P:(DE-2719)2000044$$aBeck, Heinz$$b7$$eLast author$$udzne
000138023 77318 $$2Crossref$$3journal-article$$a10.1523/jneurosci.4460-14.2015$$bSociety for Neuroscience$$d2015-06-03$$n22$$p8394-8410$$tThe Journal of Neuroscience$$v35$$x0270-6474$$y2015
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