Journal Article

DZNE-2020-04345

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.

Dannenberg, H. ; Pabst, M. ; Braganza, O. ; Schoch, S. ; Niediek, J. ; Bayraktar, M. ; Mormann, F. ; Beck, H. (Last author)DZNE*

2015
Soc.57413 Washington, DC

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Please use a persistent id in citations: doi:10.1523/JNEUROSCI.4460-14.2015

Abstract: The medial septum/diagonal band of Broca complex (MSDB) is a key structure that modulates hippocampal rhythmogenesis. Cholinergic neurons of the MSDB play a central role in generating and pacing theta-band oscillations in the hippocampal formation during exploration, novelty detection, and memory encoding. How precisely cholinergic neurons affect hippocampal network dynamics in vivo, however, has remained elusive. In this study, we show that stimulation of cholinergic MSDB neurons in urethane-anesthetized mice acts on hippocampal networks via two distinct pathways. A direct septo-hippocampal cholinergic projection causes increased firing of hippocampal inhibitory interneurons with concomitantly decreased firing of principal cells. In addition, cholinergic neurons recruit noncholinergic neurons within the MSDB. This indirect pathway is required for hippocampal theta synchronization. Activation of both pathways causes a reduction in pyramidal neuron firing and a more precise coupling to the theta oscillatory phase. These two anatomically and functionally distinct pathways are likely relevant for cholinergic control of encoding versus retrieval modes in the hippocampus.

Keyword(s): Acetylcholine: metabolism (MeSH) ; Action Potentials: genetics (MeSH) ; Animals (MeSH) ; Channelrhodopsins (MeSH) ; Choline O-Acetyltransferase: genetics (MeSH) ; Choline O-Acetyltransferase: metabolism (MeSH) ; Cholinergic Neurons: drug effects (MeSH) ; Cholinergic Neurons: physiology (MeSH) ; Dependovirus: genetics (MeSH) ; Heart Rate: drug effects (MeSH) ; Heart Rate: genetics (MeSH) ; Hippocampus: cytology (MeSH) ; Hippocampus: physiology (MeSH) ; Mice (MeSH) ; Mice, Transgenic (MeSH) ; Neural Pathways: drug effects (MeSH) ; Neural Pathways: physiology (MeSH) ; Neurons: physiology (MeSH) ; Parvalbumins: genetics (MeSH) ; Parvalbumins: metabolism (MeSH) ; Photic Stimulation (MeSH) ; Photoacoustic Techniques (MeSH) ; Septal Nuclei: physiology (MeSH) ; Theta Rhythm: genetics (MeSH) ; Theta Rhythm: physiology (MeSH) ; Time Factors (MeSH) ; Transduction, Genetic (MeSH) ; Channelrhodopsins ; Parvalbumins ; Choline O-Acetyltransferase ; Acetylcholine

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Contributing Institute(s):

1. U Preclinical Researchers - Bonn (U Preclinical Researchers - Bonn)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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