TY  - JOUR
AU  - Dannenberg, Holger
AU  - Pabst, Milan
AU  - Braganza, Oliver
AU  - Schoch, Susanne
AU  - Niediek, Johannes
AU  - Bayraktar, Melike
AU  - Mormann, Florian
AU  - Beck, Heinz
TI  - Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.
JO  - The journal of neuroscience
VL  - 35
IS  - 22
SN  - 0270-6474
CY  - Washington, DC
PB  - Soc.57413
M1  - DZNE-2020-04345
SP  - 8394-8410
PY  - 2015
AB  - The medial septum/diagonal band of Broca complex (MSDB) is a key structure that modulates hippocampal rhythmogenesis. Cholinergic neurons of the MSDB play a central role in generating and pacing theta-band oscillations in the hippocampal formation during exploration, novelty detection, and memory encoding. How precisely cholinergic neurons affect hippocampal network dynamics in vivo, however, has remained elusive. In this study, we show that stimulation of cholinergic MSDB neurons in urethane-anesthetized mice acts on hippocampal networks via two distinct pathways. A direct septo-hippocampal cholinergic projection causes increased firing of hippocampal inhibitory interneurons with concomitantly decreased firing of principal cells. In addition, cholinergic neurons recruit noncholinergic neurons within the MSDB. This indirect pathway is required for hippocampal theta synchronization. Activation of both pathways causes a reduction in pyramidal neuron firing and a more precise coupling to the theta oscillatory phase. These two anatomically and functionally distinct pathways are likely relevant for cholinergic control of encoding versus retrieval modes in the hippocampus.
KW  - Acetylcholine: metabolism
KW  - Action Potentials: genetics
KW  - Animals
KW  - Channelrhodopsins
KW  - Choline O-Acetyltransferase: genetics
KW  - Choline O-Acetyltransferase: metabolism
KW  - Cholinergic Neurons: drug effects
KW  - Cholinergic Neurons: physiology
KW  - Dependovirus: genetics
KW  - Heart Rate: drug effects
KW  - Heart Rate: genetics
KW  - Hippocampus: cytology
KW  - Hippocampus: physiology
KW  - Mice
KW  - Mice, Transgenic
KW  - Neural Pathways: drug effects
KW  - Neural Pathways: physiology
KW  - Neurons: physiology
KW  - Parvalbumins: genetics
KW  - Parvalbumins: metabolism
KW  - Photic Stimulation
KW  - Photoacoustic Techniques
KW  - Septal Nuclei: physiology
KW  - Theta Rhythm: genetics
KW  - Theta Rhythm: physiology
KW  - Time Factors
KW  - Transduction, Genetic
KW  - Channelrhodopsins (NLM Chemicals)
KW  - Parvalbumins (NLM Chemicals)
KW  - Choline O-Acetyltransferase (NLM Chemicals)
KW  - Acetylcholine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26041909
C2  - pmc:PMC6605336
DO  - DOI:10.1523/JNEUROSCI.4460-14.2015
UR  - https://pub.dzne.de/record/138023
ER  -