Home > Publications Database > Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks. > print

001     138023
005     20240321220346.0
024 7 _ |a 10.1523/JNEUROSCI.4460-14.2015
|2 doi
024 7 _ |a pmid:26041909
|2 pmid
024 7 _ |a pmc:PMC6605336
|2 pmc
024 7 _ |a 0270-6474
|2 ISSN
024 7 _ |a 1529-2401
|2 ISSN
024 7 _ |a altmetric:4087866
|2 altmetric
037 _ _ |a DZNE-2020-04345
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Dannenberg, Holger
|b 0
245 _ _ |a Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.
260 _ _ |a Washington, DC
|c 2015
|b Soc.57413
264 _ 1 |3 online
|2 Crossref
|b Society for Neuroscience
|c 2015-06-03
264 _ 1 |3 print
|2 Crossref
|b Society for Neuroscience
|c 2015-06-03
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1591199710_18838
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The medial septum/diagonal band of Broca complex (MSDB) is a key structure that modulates hippocampal rhythmogenesis. Cholinergic neurons of the MSDB play a central role in generating and pacing theta-band oscillations in the hippocampal formation during exploration, novelty detection, and memory encoding. How precisely cholinergic neurons affect hippocampal network dynamics in vivo, however, has remained elusive. In this study, we show that stimulation of cholinergic MSDB neurons in urethane-anesthetized mice acts on hippocampal networks via two distinct pathways. A direct septo-hippocampal cholinergic projection causes increased firing of hippocampal inhibitory interneurons with concomitantly decreased firing of principal cells. In addition, cholinergic neurons recruit noncholinergic neurons within the MSDB. This indirect pathway is required for hippocampal theta synchronization. Activation of both pathways causes a reduction in pyramidal neuron firing and a more precise coupling to the theta oscillatory phase. These two anatomically and functionally distinct pathways are likely relevant for cholinergic control of encoding versus retrieval modes in the hippocampus.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 0
542 _ _ |i 2015-12-03
|2 Crossref
|u https://creativecommons.org/licenses/by-nc-sa/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Channelrhodopsins
|2 NLM Chemicals
650 _ 7 |a Parvalbumins
|2 NLM Chemicals
650 _ 7 |a Choline O-Acetyltransferase
|0 EC 2.3.1.6
|2 NLM Chemicals
650 _ 7 |a Acetylcholine
|0 N9YNS0M02X
|2 NLM Chemicals
650 _ 2 |a Acetylcholine: metabolism
|2 MeSH
650 _ 2 |a Action Potentials: genetics
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Channelrhodopsins
|2 MeSH
650 _ 2 |a Choline O-Acetyltransferase: genetics
|2 MeSH
650 _ 2 |a Choline O-Acetyltransferase: metabolism
|2 MeSH
650 _ 2 |a Cholinergic Neurons: drug effects
|2 MeSH
650 _ 2 |a Cholinergic Neurons: physiology
|2 MeSH
650 _ 2 |a Dependovirus: genetics
|2 MeSH
650 _ 2 |a Heart Rate: drug effects
|2 MeSH
650 _ 2 |a Heart Rate: genetics
|2 MeSH
650 _ 2 |a Hippocampus: cytology
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Neural Pathways: drug effects
|2 MeSH
650 _ 2 |a Neural Pathways: physiology
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Parvalbumins: genetics
|2 MeSH
650 _ 2 |a Parvalbumins: metabolism
|2 MeSH
650 _ 2 |a Photic Stimulation
|2 MeSH
650 _ 2 |a Photoacoustic Techniques
|2 MeSH
650 _ 2 |a Septal Nuclei: physiology
|2 MeSH
650 _ 2 |a Theta Rhythm: genetics
|2 MeSH
650 _ 2 |a Theta Rhythm: physiology
|2 MeSH
650 _ 2 |a Time Factors
|2 MeSH
650 _ 2 |a Transduction, Genetic
|2 MeSH
700 1 _ |a Pabst, Milan
|b 1
700 1 _ |a Braganza, Oliver
|b 2
700 1 _ |a Schoch, Susanne
|b 3
700 1 _ |a Niediek, Johannes
|b 4
700 1 _ |a Bayraktar, Melike
|b 5
700 1 _ |a Mormann, Florian
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Beck, Heinz
|0 P:(DE-2719)2000044
|b 7
|e Last author
|u dzne
773 1 8 |a 10.1523/jneurosci.4460-14.2015
|b Society for Neuroscience
|d 2015-06-03
|n 22
|p 8394-8410
|3 journal-article
|2 Crossref
|t The Journal of Neuroscience
|v 35
|y 2015
|x 0270-6474
773 _ _ |a 10.1523/JNEUROSCI.4460-14.2015
|g Vol. 35, no. 22, p. 8394 - 8410
|0 PERI:(DE-600)1475274-8
|n 22
|q 35:22<8394 - 8410
|p 8394-8410
|t The journal of neuroscience
|v 35
|y 2015
|x 0270-6474
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605336
909 C O |o oai:pub.dzne.de:138023
|p VDB
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 7
|6 P:(DE-2719)2000044
913 1 _ |a DE-HGF
|b Forschungsbereich Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-342
|2 G:(DE-HGF)POF3-300
|v Disease Mechanisms and Model Systems
|x 0
914 1 _ |y 2015
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b J NEUROSCI : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b J NEUROSCI : 2017
920 1 _ |0 I:(DE-2719)7000005
|k U Preclinical Researchers - Bonn
|l U Preclinical Researchers - Bonn
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)7000005
980 _ _ |a UNRESTRICTED
999 C 5 |a 10.1016/S0006-8993(96)01304-2
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1523/JNEUROSCI.20-21-08103.2000
|9 -- missing cx lookup --
|1 Alreja
|p 8103 -
|2 Crossref
|t J Neurosci
|v 20
|y 2000
999 C 5 |a 10.1016/0006-8993(79)90040-4
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/j.bbr.2009.02.023
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1006/neur.1995.0007
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1523/JNEUROSCI.21-20-08164.2001
|9 -- missing cx lookup --
|1 Berger-Sweeney
|p 8164 -
|2 Crossref
|t J Neurosci
|v 21
|y 2001
999 C 5 |a 10.1002/cne.902590209
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1023/A:1022881625378
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0301-0082(86)90019-5
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/S0896-6273(02)00586-X
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1038/nn.3304
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/j.neulet.2011.11.019
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1523/JNEUROSCI.5040-09.2010
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/S0163-1047(89)90472-X
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/S0896-6273(00)80525-5
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1037/h0026514
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1038/336170a0
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/S0306-4522(01)00266-4
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1523/JNEUROSCI.14-06-03578.1994
|9 -- missing cx lookup --
|1 Givens
|p 3578 -
|2 Crossref
|t J Neurosci
|v 14
|y 1994
999 C 5 |a 10.1152/jn.1996.75.2.695
|9 -- missing cx lookup --
|1 Gorelova
|p 695 -
|2 Crossref
|t J Neurophysiol
|v 75
|y 1996
999 C 5 |a 10.3389/fpsyg.2011.00236
|9 -- missing cx lookup --
|2 Crossref
|u Grandchamp R Delorme A (2011) Single-trial normalization for event-related spectral decomposition reduces sensitivity to noisy trials. Front Psychol, 2.
999 C 5 |a 10.1152/jn.1954.17.6.533
|9 -- missing cx lookup --
|1 Green
|p 533 -
|2 Crossref
|t J Neurophysiol
|v 17
|y 1954
999 C 5 |a 10.1016/0304-3940(86)90553-7
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1523/JNEUROSCI.5665-08.2009
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1152/jn.2000.84.1.401
|9 -- missing cx lookup --
|1 Harris
|p 401 -
|2 Crossref
|t J Neurophysiol
|v 84
|y 2000
999 C 5 |a 10.1523/JNEUROSCI.15-07-05249.1995
|9 -- missing cx lookup --
|1 Hasselmo
|p 5249 -
|2 Crossref
|t J Neurosci
|v 15
|y 1995
999 C 5 |a 10.1162/089976602317318965
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1523/JNEUROSCI.17-16-06470.1997
|9 -- missing cx lookup --
|1 Hölscher
|p 6470 -
|2 Crossref
|t J Neurosci
|v 17
|y 1997
999 C 5 |a 10.1523/JNEUROSCI.3663-10.2010
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1523/JNEUROSCI.23-37-11725.2003
|9 -- missing cx lookup --
|1 Hyman
|p 11725 -
|2 Crossref
|t J Neurosci
|v 23
|y 2003
999 C 5 |a 10.1152/jn.2000.83.5.2682
|9 -- missing cx lookup --
|1 Ji
|p 2682 -
|2 Crossref
|t J Neurophysiol
|v 83
|y 2000
999 C 5 |a 10.1016/0006-8993(87)91009-2
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1111/ejn.12091
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0014-4886(75)90195-8
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1113/jphysiol.2005.100875
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1006/exnr.1993.1047
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0306-4522(94)90341-7
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1002/cne.902890210
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1038/nn.3038
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1126/science.1247485
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0006-8993(90)91106-Q
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0306-4522(83)90108-2
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1002/hipo.20422
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/j.cub.2005.11.032
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1371/journal.pone.0027691
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1113/jphysiol.2013.257428
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1155/2011/156869
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1002/hipo.1079
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0006-8993(88)91499-0
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |2 Crossref
|u Paxinos G Franklin KBJ (2008) The mouse brain in stereotaxic coordinates, the coronal plates and diagrams (Academic, Amsterdam), Ed 3.
999 C 5 |a 10.1016/0013-4694(62)90030-5
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1038/nn.3552
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1162/089976604774201631
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1007/BF01474253
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/S1074-7427(03)00063-7
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1038/nature08860
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0306-4522(96)00349-1
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1113/jphysiol.2003.046847
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/j.neulet.2012.01.033
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0166-2236(90)90040-H
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1016/0013-4694(62)90031-7
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1111/j.1469-7793.1997.463bh.x
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1074/jbc.M111.310763
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1073/pnas.1411233111
|9 -- missing cx lookup --
|2 Crossref
|u Vandecasteele M Varga V Berényi A Papp E Barthó P Venance L Freund TF Buzsáki G (2014) Optogenetic activation of septal cholinergic neurons suppresses sharp wave ripples and enhances theta oscillations in the hippocampus. Proc Natl Acad Sci U S A.
999 C 5 |a 10.1113/jphysiol.2008.155242
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1002/hipo.20191
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1073/pnas.0813176106
|9 -- missing cx lookup --
|2 Crossref
999 C 5 |a 10.1002/hipo.20062
|9 -- missing cx lookup --
|2 Crossref

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21