Journal Article (Review Article)

DZNE-2020-04370

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Presynaptic active zones in invertebrates and vertebrates.

Ackermann, F. (First author)DZNE* ; Waites, C. L. ; Garner, C. C. (Last author)DZNE*

2015
Wiley Hoboken, NJ [u.a.]

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Please use a persistent id in citations: doi:10.15252/embr.201540434

Abstract: The regulated release of neurotransmitter occurs via the fusion of synaptic vesicles (SVs) at specialized regions of the presynaptic membrane called active zones (AZs). These regions are defined by a cytoskeletal matrix assembled at AZs (CAZ), which functions to direct SVs toward docking and fusion sites and supports their maturation into the readily releasable pool. In addition, CAZ proteins localize voltage-gated Ca(2+) channels at SV release sites, bringing the fusion machinery in close proximity to the calcium source. Proteins of the CAZ therefore ensure that vesicle fusion is temporally and spatially organized, allowing for the precise and reliable release of neurotransmitter. Importantly, AZs are highly dynamic structures, supporting presynaptic remodeling, changes in neurotransmitter release efficacy, and thus presynaptic forms of plasticity. In this review, we discuss recent advances in the study of active zones, highlighting how the CAZ molecularly defines sites of neurotransmitter release, endocytic zones, and the integrity of synapses.

Keyword(s): Animals (MeSH) ; Caenorhabditis elegans: physiology (MeSH) ; Calcium: metabolism (MeSH) ; Cytoskeleton: chemistry (MeSH) ; Cytoskeleton: metabolism (MeSH) ; Invertebrates: cytology (MeSH) ; Invertebrates: physiology (MeSH) ; Nerve Tissue Proteins: metabolism (MeSH) ; Neurotransmitter Agents: metabolism (MeSH) ; Presynaptic Terminals: physiology (MeSH) ; Synapses: chemistry (MeSH) ; Synapses: diagnostic imaging (MeSH) ; Synapses: physiology (MeSH) ; Synaptic Transmission (MeSH) ; Synaptic Vesicles: physiology (MeSH) ; Ultrasonography (MeSH) ; Vertebrates: physiology (MeSH) ; Nerve Tissue Proteins ; Neurotransmitter Agents ; Calcium

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Contributing Institute(s):

1. Synaptopathy (AG Garner)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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