%0 Journal Article
%A Toledo, Jon B
%A Zetterberg, Henrik
%A van Harten, Argonde C
%A Glodzik, Lidia
%A Martinez-Lage, Pablo
%A Bocchio-Chiavetto, Luisella
%A Rami, Lorena
%A Hansson, Oskar
%A Sperling, Reisa
%A Engelborghs, Sebastiaan
%A Osorio, Ricardo S
%A Vanderstichele, Hugo
%A Vandijck, Manu
%A Hampel, Harald
%A Teipel, Stefan
%A Moghekar, Abhay
%A Albert, Marilyn
%A Hu, William T
%A Monge Argilés, Jose A
%A Gorostidi, Ana
%A Teunissen, Charlotte E
%A De Deyn, Peter P
%A Hyman, Bradley T
%A Molinuevo, Jose L
%A Frisoni, Giovanni B
%A Linazasoro, Gurutz
%A de Leon, Mony J
%A van der Flier, Wiesje M
%A Scheltens, Philip
%A Blennow, Kaj
%A Shaw, Leslie M
%A Trojanowski, John Q
%A Initiative, Alzheimer’s Disease Neuroimaging
%A Weiner, Michael W
%A Aisen, Paul
%A Weiner, Michael
%A Aisen, Paul
%A Petersen, Ronald
%A Jack, Clifford R
%A Jagust, William
%A Trojanowki, John Q
%A Toga, Arthur W
%A Beckett, Laurel
%A Green, Robert C
%A Saykin, Andrew J
%A Morris, John
%A Shaw, Leslie M
%A Khachaturian, Zaven
%A Sorensen, Greg
%A Carrillo, Maria
%A Kuller, Lew
%A Raichle, Marc
%A Paul, Steven
%A Davies, Peter
%A Fillit, Howard
%A Hefti, Franz
%A Holtzman, Davie
%A Mesulam, M Marcel
%A Potter, William
%A Snyder, Peter
%A Schwartz, Adam
%A Green, Robert C
%A Montine, Tom
%A Petersen, Ronald
%A Aisen, Paul
%A Thomas, Ronald G
%A Donohue, Michael
%A Walter, Sarah
%A Gessert, Devon
%A Sather, Tamie
%A Jiminez, Gus
%A Balasubramanian, Archana B
%A Mason, Jennifer
%A Sim, Iris
%A Beckett, Laurel
%A Harvey, Danielle
%A Donohue, Michael
%A Jack, Clifford R
%A Bernstein, Matthew
%A Fox, Nick
%A Thompson, Paul
%A Schuff, Norbert
%A DeCArli, Charles
%A Borowski, Bret
%A Gunter, Jeff
%A Senjem, Matt
%A Vemuri, Prashanthi
%A Jones, David
%A Kantarci, Kejal
%A Ward, Chad
%A Jagust, William
%A Koeppe, Robert A
%A Foster, Norm
%A Reiman, Eric M
%A Chen, Kewei
%A Mathis, Chet
%A Landau, Susan
%A Morris, John C
%A Cairns, Nigel J
%A Householder, Erin
%A Taylor-Reinwald, Lisa
%A Shaw, Leslie M
%A Trojanowki, John Q
%A Lee, Virginia
%A Korecka, Magdalena
%A Figurski, Michal
%A Toga, Arthur W
%A Crawford, Karen
%A Neu, Scott
%A Saykin, Andrew J
%A Foroud, Tatiana M
%A Potkin, Steven
%A Shen, Li
%A Faber, Kelley
%A Kim, Sungeun
%A Nho, Kwangsik
%A Weiner, Michael W
%A Thal, Lean
%A Khachaturian, Zaven
%A Thal, Leon
%A Buckholtz, Neil
%A Weiner, Michael W
%A Snyder, Peter J
%A Potter, William
%A Paul, Steven
%A Albert, Marylyn
%A Frank, Richard
%A Khachaturian, Zaven
%A Hsiao, John
%A Kaye, Jeffrey
%A Quinn, Joseph
%A Silbert, Lisa
%A Lind, Betty
%A Carter, Raina
%A Dolen, Sara
%A Schneider, Lon S
%A Pawluczyk, Sonia
%A Beccera, Mauricio
%A Teodoro, Liberty
%A Spann, Bryan M
%A Brewer, James
%A Vanderswag, Helen
%A Fleisher, Adam
%A Heidebrink, Judith L
%A Lord, Joanne L
%A Petersen, Ronald
%A Mason, Sara S
%A Albers, Colleen S
%A Knopman, David
%A Johnson, Kris
%A Doody, Rachelle S
%A Villanueva-Meyer, Javier
%A Chowdhury, Munir
%A Rountree, Susan
%A Dang, Mimi
%A Stern, Yaakov
%A Honig, Lawrence S
%A Bell, Karen L
%A Ances, Beau
%A Morris, John C
%A Carroll, Maria
%A Creech, Mary L
%A Franklin, Erin
%A Mintun, Mark A
%A Schneider, Stacy
%A Oliver, Angela
%A Marson, Daniel
%A Griffith, Randall
%A Clark, David
%A Geldmacher, David
%A Brockington, John
%A Roberson, Erik
%A Love, Marissa Natelson
%A Grossman, Hillel
%A Mitsis, Effie
%A Shah, Raj C
%A deToledo-Morrell, Leyla
%A Duara, Ranjan
%A Varon, Daniel
%A Greig, Maria T
%A Roberts, Peggy
%A Albert, Marilyn
%A Onyike, Chiadi
%A D' Agostino, Daniel
%A Kielb, Stephanie
%A Galvin, James E
%A Cerbone, Brittany
%A Michel, Christina A
%A Pogorelec, Dana M
%A Rusinek, Henry
%A de Leon, Mony J
%A Glodzik, Lidia
%A De Santi, Susan
%A Doraiswamy, P Murali
%A Petrella, Jeffrey R
%A Borges-Neto, Salvador
%A Wong, Terence Z
%A Coleman, Edward
%A Arnold, Steven E
%A Karlawish, Jason H
%A Wolk, David
%A Clark, Christopher M
%A Smith, Charles D
%A Jicha, Greg
%A Hardy, Peter
%A Sinha, Partha
%A Oates, Elizabeth
%A Conrad, Gary
%A Lopez, Oscar L
%A Oakley, MaryAnn
%A Simpson, Donna M
%A Porsteinsson, Anton P
%A Goldstein, Bonnie S
%A Martin, Kim
%A Makino, Kelly M
%A Ismail, M Saleem
%A Brand, Connie
%A Mulnard, Ruth A
%A Thai, Gaby
%A Mc-Adams-Ortiz, Catherine
%A Womack, Kyle
%A Mathews, Dana
%A Quiceno, Mary
%A Levey, Allan I
%A Lah, James J
%A Cellar, Janet S
%A Burns, Jeffrey M
%A Swerdlow, Russell H
%A Brooks, William M
%A Apostolova, Liana
%A Tingus, Kathleen
%A Woo, Ellen
%A Silverman, Daniel H S
%A Lu, Po H
%A Bartzokis, George
%A Graff-Radford, Neill R
%A Parfitt, Francine
%A Kendall, Tracy
%A Johnson, Heather
%A Farlow, Martin R
%A Hake, Ann Marie
%A Matthews, Brandy R
%A Brosch, Jared R
%A Herring, Scott
%A Hunt, Cynthia
%A van Dyck, Christopher H
%A Carson, Richard E
%A MacAvoy, Martha G
%A Varma, Pradeep
%A Chertkow, Howard
%A Bergman, Howard
%A Hosein, Chris
%A Black, Sandra
%A Stefanovic, Bojana
%A Caldwell, Curtis
%A Hsiung, Ging-Yuek Robin
%A Feldman, Howard
%A Mudge, Benita
%A Assaly, Michele
%A Finger, Elizabeth
%A Pasternack, Stephen
%A Rachisky, Irina
%A Trost, Dick
%A Kertesz, Andrew
%A Bernick, Charles
%A Munic, Donna
%A Mesulam, Marek-Marsel
%A Lipowski, Kristine
%A Weintraub, MaSandra
%A Bonakdarpour, Borna
%A Kerwin, Diana
%A Wu, Chuang-Kuo
%A Johnson, Nancy
%A Sadowsky, Carl
%A Villena, Teresa
%A Turner, Raymond Scott
%A Johnson, Kathleen
%A Reynolds, Brigid
%A Sperling, Reisa A
%A Johnson, Keith A
%A Marshall, Gad
%A Yesavage, Jerome
%A Taylor, Joy L
%A Lane, Barton
%A Rosen, Allyson
%A Tinklenberg, Jared
%A Sabbagh, Marwan N
%A Belden, Christine M
%A Jacobson, Sandra A
%A Sirrel, Sherye A
%A Kowall, Neil
%A Killiany, Ronald
%A Budson, Andrew E
%A Norbash, Alexander
%A Johnson, Patricia Lynn
%A Obisesan, Thomas O
%A Wolday, Saba
%A Allard, Joanne
%A Lerner, Alan
%A Ogrocki, Paula
%A Tatsuoka, Curtis
%A Fatica, Parianne
%A Fletcher, Evan
%A Maillard, Pauline
%A Olichney, John
%A DeCarli, Charles
%A Carmichael, Owen
%A Kittur, Smita
%A Borrie, Michael
%A Lee, T-Y
%A Bartha, Rob
%A Asthana, Sanjay
%A Carlsson, Cynthia M
%A Potkin, Steven G
%A Preda, Adrian
%A Nguyen, Dana
%A Tariot, Pierre
%A Burke, Anna
%A Trncic, Nadira
%A Fleisher, Adam
%A Reeder, Stephanie
%A Bates, Vernice
%A Capote, Horacio
%A Rainka, Michelle
%A Scharre, Douglas W
%A Kataki, Maria
%A Adeli, Anahita
%A Zimmerman, Earl A
%A Celmins, Dzintra
%A Brown, Alice D
%A Pearlson, Godfrey D
%A Blank, Karen
%A Anderson, Karen
%A Flashman, Laura A
%A Seltzer, Marc
%A Hynes, Mary L
%A Santulli, Robert B
%A Sink, Kaycee M
%A Gordineer, Leslie
%A Williamson, Jeff D
%A Garg, Pradeep
%A Watkins, Franklin
%A Ott, Brian R
%A Querfurth, Henry
%A Tremont, Geoffrey
%A Salloway, Stephen
%A Malloy, Paul
%A Correia, Stephen
%A Rosen, Howard J
%A Miller, Bruce L
%A Perry, David
%A Mintzer, Jacobo
%A Spicer, Kenneth
%A Bachman, David
%A Finger, Elizabether
%A Pasternak, Stephen
%A Rachinsky, Irina
%A Rogers, John
%A Kertesz, Andrew
%A Drost, Dick
%A Pomara, Nunzio
%A Hernando, Raymundo
%A Sarrael, Antero
%A Schultz, Susan K
%A Ponto, Laura L Boles
%A Shim, Hyungsub
%A Smith, Karen Ekstam
%A Relkin, Norman
%A Chaing, Gloria
%A Lin, Michael
%A Ravdin, Lisa
%A Smith, Amanda
%A Raj, Balebail Ashok
%A Fargher, Kristin
%A Weiner, Michael W
%A Aisen, Paul
%A Weiner, Michael
%A Aisen, Paul
%A Petersen, Ronald
%A Green, Robert C
%A Harvey, Danielle
%A Jack, Clifford R
%A Jagust, William
%A Morris, John C
%A Saykin, Andrew J
%A Shaw, Leslie M
%A Trojanowki, John Q
%A Neylan, Thomas
%A Grafman, Jordan
%A Green, Robert C
%A Montine, Tom
%A Weiner, Michael
%A Petersen, Ronald
%A Aisen, Paul
%A Thomas, Ronald G
%A Donohue, Michael
%A Gessert, Devon
%A Sather, Tamie
%A Davis, Melissa
%A Morrison, Rosemary
%A Jiminez, Gus
%A Neylan, Thomas
%A Hayes, Jacqueline
%A Finley, Shannon
%A Harvey, Danielle
%A Donohue, Michael
%A Jack, Clifford R
%A Bernstein, Matthew
%A Borowski, Bret
%A Gunter, Jeff
%A Senjem, Matt
%A Kantarci, Kejal
%A Jagust, William
%A Koeppe, Robert A
%A Foster, Norm
%A Reiman, Eric M
%A Chen, Kewei
%A Landau, Susan
%A Morris, John C
%A Cairns, Nigel J
%A Householder, Erin
%A Shaw, Leslie M
%A Trojanowki, John Q
%A Lee, Virginia
%A Korecka, Magdalena
%A Figurski, Michal
%A Toga, Arthur W
%A Crawford, Karen
%A Neu, Scott
%A Saykin, Andrew J
%A Foroud, Tatiana M
%A Potkin, Steven
%A Shen, Li
%A Faber, Kelley
%A Kim, Sungeun
%A Weiner, Michael W
%A Schneider, Lon S
%A Pawluczyk, Sonia
%A Beccera, Mauricio
%A Brewer, James
%A Vanderswag, Helen
%A Stern, Yaakov
%A Honig, Lawrence S
%A Bell, Karen L
%A Fleischman, Debra
%A Arfanakis, Konstantinos
%A Shah, Raj C
%A Duara, Ranjan
%A Varon, Daniel
%A Greig, Maria T
%A Doraiswamy, P Murali
%A Petrella, Jeffrey R
%A James, Olga
%A Porsteinsson, Anton P
%A Goldstein, Bonnie
%A Martin, Kimberly S
%A Mulnard, Ruth A
%A Thai, Gaby
%A McAdams-Ortiz, Catherine
%A Mintzer, Jacobo
%A Massoglia, Dino
%A Brawman-Mintzer, Olga
%A Sadowsky, Carl
%A Martinez, Walter
%A Villena, Teresa
%A Jagust, William
%A Landau, Susan
%A Rosen, Howard
%A Perry, David
%A Turner, Raymond Scott
%A Behan, Kelly
%A Reynolds, Brigid
%A Sperling, Reisa A
%A Johnson, Keith A
%A Marshall, Gad
%A Sabbagh, Marwan N
%A Jacobson, Sandra A
%A Sirrel, Sherye A
%A Obisesan, Thomas O
%A Wolday, Saba
%A Allard, Joanne
%A Johnson, Sterling C
%A Fruehling, J Jay
%A Harding, Sandra
%A Peskind, Elaine R
%A Petrie, Eric C
%A Li, Gail
%A Yesavage, Jerome A
%A Taylor, Joy L
%A Furst, Ansgar J
%A Chao, Steven
%A Relkin, Norman
%A Chaing, Gloria
%A Ravdin, Lisa
%T Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects.
%J Brain
%V 138
%N 9
%@ 0006-8950
%C Oxford
%I Oxford Univ. Press
%M DZNE-2020-04443
%P 2701-2715
%D 2015
%X In a large multicentre sample of cognitively normal subjects, as a function of age, gender and APOE genotype, we studied the frequency of abnormal cerebrospinal fluid levels of Alzheimer's disease biomarkers including: total tau, phosphorylated tau and amyloid-β1-42. Fifteen cohorts from 12 different centres with either enzyme-linked immunosorbent assays or Luminex® measurements were selected for this study. Each centre sent nine new cerebrospinal fluid aliquots that were used to measure total tau, phosphorylated tau and amyloid-β1-42 in the Gothenburg laboratory. Seven centres showed a high correlation with the new Gothenburg measurements; therefore, 10 cohorts from these centres are included in the analyses here (1233 healthy control subjects, 40-84 years old). Amyloid-β amyloid status (negative or positive) and neurodegeneration status (negative or positive) was established based on the pathological cerebrospinal fluid Alzheimer's disease cut-off values for cerebrospinal fluid amyloid-β1-42 and total tau, respectively. While gender did not affect these biomarker values, APOE genotype modified the age-associated changes in cerebrospinal fluid biomarkers such that APOE ε4 carriers showed stronger age-related changes in cerebrospinal fluid phosphorylated tau, total tau and amyloid-β1-42 values and APOE ε2 carriers showed the opposite effect. At 40 years of age, 76
%K Adult
%K Age Factors
%K Aged
%K Aged, 80 and over
%K Alzheimer Disease: cerebrospinal fluid
%K Alzheimer Disease: genetics
%K Alzheimer Disease: physiopathology
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Analysis of Variance
%K Apolipoproteins E: genetics
%K Cognition: physiology
%K Cohort Studies
%K Female
%K Humans
%K Male
%K Middle Aged
%K Neurodegenerative Diseases: etiology
%K Neuropsychological Tests
%K Peptide Fragments: cerebrospinal fluid
%K Severity of Illness Index
%K tau Proteins: cerebrospinal fluid
%K Amyloid beta-Peptides (NLM Chemicals)
%K Apolipoproteins E (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%K amyloid beta-protein (1-42) (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26220940
%2 pmc:PMC4643624
%R 10.1093/brain/awv199
%U https://pub.dzne.de/record/138121