| Home > Publications Database > Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. > print |
| 001 | 138121 | ||
| 005 | 20240321220356.0 | ||
| 024 | 7 | _ | |a 10.1093/brain/awv199 |2 doi |
| 024 | 7 | _ | |a pmid:26220940 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC4643624 |2 pmc |
| 024 | 7 | _ | |a 0006-8950 |2 ISSN |
| 024 | 7 | _ | |a 1460-2156 |2 ISSN |
| 024 | 7 | _ | |a altmetric:4345495 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-04443 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Toledo, Jon B |b 0 |
| 245 | _ | _ | |a Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. |
| 260 | _ | _ | |a Oxford |c 2015 |b Oxford Univ. Press |
| 264 | _ | 1 | |3 online |2 Crossref |b Oxford University Press (OUP) |c 2015-07-27 |
| 264 | _ | 1 | |3 print |2 Crossref |b Oxford University Press (OUP) |c 2015-09-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1588244286_17521 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a In a large multicentre sample of cognitively normal subjects, as a function of age, gender and APOE genotype, we studied the frequency of abnormal cerebrospinal fluid levels of Alzheimer's disease biomarkers including: total tau, phosphorylated tau and amyloid-β1-42. Fifteen cohorts from 12 different centres with either enzyme-linked immunosorbent assays or Luminex® measurements were selected for this study. Each centre sent nine new cerebrospinal fluid aliquots that were used to measure total tau, phosphorylated tau and amyloid-β1-42 in the Gothenburg laboratory. Seven centres showed a high correlation with the new Gothenburg measurements; therefore, 10 cohorts from these centres are included in the analyses here (1233 healthy control subjects, 40-84 years old). Amyloid-β amyloid status (negative or positive) and neurodegeneration status (negative or positive) was established based on the pathological cerebrospinal fluid Alzheimer's disease cut-off values for cerebrospinal fluid amyloid-β1-42 and total tau, respectively. While gender did not affect these biomarker values, APOE genotype modified the age-associated changes in cerebrospinal fluid biomarkers such that APOE ε4 carriers showed stronger age-related changes in cerebrospinal fluid phosphorylated tau, total tau and amyloid-β1-42 values and APOE ε2 carriers showed the opposite effect. At 40 years of age, 76% of the subjects were classified as amyloid negative, neurodegeneration negative and their frequency decreased to 32% at 85 years. The amyloid-positive neurodegeneration-negative group remained stable. The amyloid-negative neurodegeneration-positive group frequency increased slowly from 1% at 44 years to 16% at 85 years, but its frequency was not affected by APOE genotype. The amyloid-positive neurodegeneration-positive frequency increased from 1% at 53 years to 28% at 85 years. Abnormally low cerebrospinal fluid amyloid-β1-42 levels were already frequent in midlife and APOE genotype strongly affects the levels of cerebrospinal fluid amyloid-β1-42, phosphorylated tau and total tau across the lifespan without influencing the frequency of subjects with suspected non-amyloid pathology. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Amyloid beta-Peptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Apolipoproteins E |2 NLM Chemicals |
| 650 | _ | 7 | |a Peptide Fragments |2 NLM Chemicals |
| 650 | _ | 7 | |a amyloid beta-protein (1-42) |2 NLM Chemicals |
| 650 | _ | 7 | |a tau Proteins |2 NLM Chemicals |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Age Factors |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Aged, 80 and over |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Analysis of Variance |2 MeSH |
| 650 | _ | 2 | |a Apolipoproteins E: genetics |2 MeSH |
| 650 | _ | 2 | |a Cognition: physiology |2 MeSH |
| 650 | _ | 2 | |a Cohort Studies |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Neurodegenerative Diseases: etiology |2 MeSH |
| 650 | _ | 2 | |a Neuropsychological Tests |2 MeSH |
| 650 | _ | 2 | |a Peptide Fragments: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Severity of Illness Index |2 MeSH |
| 650 | _ | 2 | |a tau Proteins: cerebrospinal fluid |2 MeSH |
| 700 | 1 | _ | |a Zetterberg, Henrik |b 1 |
| 700 | 1 | _ | |a van Harten, Argonde C |b 2 |
| 700 | 1 | _ | |a Glodzik, Lidia |b 3 |
| 700 | 1 | _ | |a Martinez-Lage, Pablo |b 4 |
| 700 | 1 | _ | |a Bocchio-Chiavetto, Luisella |b 5 |
| 700 | 1 | _ | |a Rami, Lorena |b 6 |
| 700 | 1 | _ | |a Hansson, Oskar |b 7 |
| 700 | 1 | _ | |a Sperling, Reisa |b 8 |
| 700 | 1 | _ | |a Engelborghs, Sebastiaan |b 9 |
| 700 | 1 | _ | |a Osorio, Ricardo S |b 10 |
| 700 | 1 | _ | |a Vanderstichele, Hugo |b 11 |
| 700 | 1 | _ | |a Vandijck, Manu |b 12 |
| 700 | 1 | _ | |a Hampel, Harald |b 13 |
| 700 | 1 | _ | |a Teipel, Stefan |0 P:(DE-2719)2000026 |b 14 |u dzne |
| 700 | 1 | _ | |a Moghekar, Abhay |b 15 |
| 700 | 1 | _ | |a Albert, Marilyn |b 16 |
| 700 | 1 | _ | |a Hu, William T |b 17 |
| 700 | 1 | _ | |a Monge Argilés, Jose A |b 18 |
| 700 | 1 | _ | |a Gorostidi, Ana |b 19 |
| 700 | 1 | _ | |a Teunissen, Charlotte E |b 20 |
| 700 | 1 | _ | |a De Deyn, Peter P |b 21 |
| 700 | 1 | _ | |a Hyman, Bradley T |b 22 |
| 700 | 1 | _ | |a Molinuevo, Jose L |b 23 |
| 700 | 1 | _ | |a Frisoni, Giovanni B |b 24 |
| 700 | 1 | _ | |a Linazasoro, Gurutz |b 25 |
| 700 | 1 | _ | |a de Leon, Mony J |b 26 |
| 700 | 1 | _ | |a van der Flier, Wiesje M |b 27 |
| 700 | 1 | _ | |a Scheltens, Philip |b 28 |
| 700 | 1 | _ | |a Blennow, Kaj |b 29 |
| 700 | 1 | _ | |a Shaw, Leslie M |0 P:(DE-HGF)0 |b 30 |
| 700 | 1 | _ | |a Trojanowski, John Q |0 P:(DE-HGF)0 |b 31 |e Corresponding author |
| 700 | 1 | _ | |a Initiative, Alzheimer’s Disease Neuroimaging |b 32 |
| 700 | 1 | _ | |a Weiner, Michael W |b 33 |
| 700 | 1 | _ | |a Aisen, Paul |b 34 |
| 700 | 1 | _ | |a Weiner, Michael |b 35 |
| 700 | 1 | _ | |a Aisen, Paul |b 36 |
| 700 | 1 | _ | |a Petersen, Ronald |b 37 |
| 700 | 1 | _ | |a Jack, Clifford R |b 38 |
| 700 | 1 | _ | |a Jagust, William |b 39 |
| 700 | 1 | _ | |a Trojanowki, John Q |b 40 |
| 700 | 1 | _ | |a Toga, Arthur W |b 41 |
| 700 | 1 | _ | |a Beckett, Laurel |b 42 |
| 700 | 1 | _ | |a Green, Robert C |b 43 |
| 700 | 1 | _ | |a Saykin, Andrew J |b 44 |
| 700 | 1 | _ | |a Morris, John |b 45 |
| 700 | 1 | _ | |a Shaw, Leslie M |0 P:(DE-HGF)0 |b 46 |
| 700 | 1 | _ | |a Khachaturian, Zaven |b 47 |
| 700 | 1 | _ | |a Sorensen, Greg |b 48 |
| 700 | 1 | _ | |a Carrillo, Maria |b 49 |
| 700 | 1 | _ | |a Kuller, Lew |b 50 |
| 700 | 1 | _ | |a Raichle, Marc |b 51 |
| 700 | 1 | _ | |a Paul, Steven |b 52 |
| 700 | 1 | _ | |a Davies, Peter |b 53 |
| 700 | 1 | _ | |a Fillit, Howard |b 54 |
| 700 | 1 | _ | |a Hefti, Franz |b 55 |
| 700 | 1 | _ | |a Holtzman, Davie |b 56 |
| 700 | 1 | _ | |a Mesulam, M Marcel |b 57 |
| 700 | 1 | _ | |a Potter, William |b 58 |
| 700 | 1 | _ | |a Snyder, Peter |b 59 |
| 700 | 1 | _ | |a Schwartz, Adam |b 60 |
| 700 | 1 | _ | |a Green, Robert C |b 61 |
| 700 | 1 | _ | |a Montine, Tom |b 62 |
| 700 | 1 | _ | |a Petersen, Ronald |b 63 |
| 700 | 1 | _ | |a Aisen, Paul |b 64 |
| 700 | 1 | _ | |a Thomas, Ronald G |b 65 |
| 700 | 1 | _ | |a Donohue, Michael |b 66 |
| 700 | 1 | _ | |a Walter, Sarah |b 67 |
| 700 | 1 | _ | |a Gessert, Devon |b 68 |
| 700 | 1 | _ | |a Sather, Tamie |b 69 |
| 700 | 1 | _ | |a Jiminez, Gus |b 70 |
| 700 | 1 | _ | |a Balasubramanian, Archana B |b 71 |
| 700 | 1 | _ | |a Mason, Jennifer |b 72 |
| 700 | 1 | _ | |a Sim, Iris |b 73 |
| 700 | 1 | _ | |a Beckett, Laurel |b 74 |
| 700 | 1 | _ | |a Harvey, Danielle |b 75 |
| 700 | 1 | _ | |a Donohue, Michael |b 76 |
| 700 | 1 | _ | |a Jack, Clifford R |b 77 |
| 700 | 1 | _ | |a Bernstein, Matthew |b 78 |
| 700 | 1 | _ | |a Fox, Nick |b 79 |
| 700 | 1 | _ | |a Thompson, Paul |b 80 |
| 700 | 1 | _ | |a Schuff, Norbert |b 81 |
| 700 | 1 | _ | |a DeCArli, Charles |b 82 |
| 700 | 1 | _ | |a Borowski, Bret |b 83 |
| 700 | 1 | _ | |a Gunter, Jeff |b 84 |
| 700 | 1 | _ | |a Senjem, Matt |b 85 |
| 700 | 1 | _ | |a Vemuri, Prashanthi |b 86 |
| 700 | 1 | _ | |a Jones, David |b 87 |
| 700 | 1 | _ | |a Kantarci, Kejal |b 88 |
| 700 | 1 | _ | |a Ward, Chad |b 89 |
| 700 | 1 | _ | |a Jagust, William |b 90 |
| 700 | 1 | _ | |a Koeppe, Robert A |b 91 |
| 700 | 1 | _ | |a Foster, Norm |b 92 |
| 700 | 1 | _ | |a Reiman, Eric M |b 93 |
| 700 | 1 | _ | |a Chen, Kewei |b 94 |
| 700 | 1 | _ | |a Mathis, Chet |b 95 |
| 700 | 1 | _ | |a Landau, Susan |b 96 |
| 700 | 1 | _ | |a Morris, John C |b 97 |
| 700 | 1 | _ | |a Cairns, Nigel J |b 98 |
| 700 | 1 | _ | |a Householder, Erin |b 99 |
| 700 | 1 | _ | |a Taylor-Reinwald, Lisa |b 100 |
| 700 | 1 | _ | |a Shaw, Leslie M |0 P:(DE-HGF)0 |b 101 |
| 700 | 1 | _ | |a Trojanowki, John Q |b 102 |
| 700 | 1 | _ | |a Lee, Virginia |b 103 |
| 700 | 1 | _ | |a Korecka, Magdalena |b 104 |
| 700 | 1 | _ | |a Figurski, Michal |b 105 |
| 700 | 1 | _ | |a Toga, Arthur W |b 106 |
| 700 | 1 | _ | |a Crawford, Karen |b 107 |
| 700 | 1 | _ | |a Neu, Scott |b 108 |
| 700 | 1 | _ | |a Saykin, Andrew J |b 109 |
| 700 | 1 | _ | |a Foroud, Tatiana M |b 110 |
| 700 | 1 | _ | |a Potkin, Steven |b 111 |
| 700 | 1 | _ | |a Shen, Li |b 112 |
| 700 | 1 | _ | |a Faber, Kelley |b 113 |
| 700 | 1 | _ | |a Kim, Sungeun |b 114 |
| 700 | 1 | _ | |a Nho, Kwangsik |b 115 |
| 700 | 1 | _ | |a Weiner, Michael W |b 116 |
| 700 | 1 | _ | |a Thal, Lean |b 117 |
| 700 | 1 | _ | |a Khachaturian, Zaven |b 118 |
| 700 | 1 | _ | |a Thal, Leon |b 119 |
| 700 | 1 | _ | |a Buckholtz, Neil |b 120 |
| 700 | 1 | _ | |a Weiner, Michael W |b 121 |
| 700 | 1 | _ | |a Snyder, Peter J |b 122 |
| 700 | 1 | _ | |a Potter, William |b 123 |
| 700 | 1 | _ | |a Paul, Steven |b 124 |
| 700 | 1 | _ | |a Albert, Marylyn |b 125 |
| 700 | 1 | _ | |a Frank, Richard |b 126 |
| 700 | 1 | _ | |a Khachaturian, Zaven |b 127 |
| 700 | 1 | _ | |a Hsiao, John |b 128 |
| 700 | 1 | _ | |a Kaye, Jeffrey |b 129 |
| 700 | 1 | _ | |a Quinn, Joseph |b 130 |
| 700 | 1 | _ | |a Silbert, Lisa |b 131 |
| 700 | 1 | _ | |a Lind, Betty |b 132 |
| 700 | 1 | _ | |a Carter, Raina |b 133 |
| 700 | 1 | _ | |a Dolen, Sara |b 134 |
| 700 | 1 | _ | |a Schneider, Lon S |b 135 |
| 700 | 1 | _ | |a Pawluczyk, Sonia |b 136 |
| 700 | 1 | _ | |a Beccera, Mauricio |b 137 |
| 700 | 1 | _ | |a Teodoro, Liberty |b 138 |
| 700 | 1 | _ | |a Spann, Bryan M |b 139 |
| 700 | 1 | _ | |a Brewer, James |b 140 |
| 700 | 1 | _ | |a Vanderswag, Helen |b 141 |
| 700 | 1 | _ | |a Fleisher, Adam |b 142 |
| 700 | 1 | _ | |a Heidebrink, Judith L |b 143 |
| 700 | 1 | _ | |a Lord, Joanne L |b 144 |
| 700 | 1 | _ | |a Petersen, Ronald |b 145 |
| 700 | 1 | _ | |a Mason, Sara S |b 146 |
| 700 | 1 | _ | |a Albers, Colleen S |b 147 |
| 700 | 1 | _ | |a Knopman, David |0 P:(DE-HGF)0 |b 148 |
| 700 | 1 | _ | |a Johnson, Kris |b 149 |
| 700 | 1 | _ | |a Doody, Rachelle S |b 150 |
| 700 | 1 | _ | |a Villanueva-Meyer, Javier |b 151 |
| 700 | 1 | _ | |a Chowdhury, Munir |b 152 |
| 700 | 1 | _ | |a Rountree, Susan |b 153 |
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| 700 | 1 | _ | |a Stern, Yaakov |b 155 |
| 700 | 1 | _ | |a Honig, Lawrence S |b 156 |
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| 700 | 1 | _ | |a Creech, Mary L |b 161 |
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| 700 | 1 | _ | |a Mintun, Mark A |b 163 |
| 700 | 1 | _ | |a Schneider, Stacy |b 164 |
| 700 | 1 | _ | |a Oliver, Angela |b 165 |
| 700 | 1 | _ | |a Marson, Daniel |b 166 |
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| 700 | 1 | _ | |a Geldmacher, David |b 169 |
| 700 | 1 | _ | |a Brockington, John |b 170 |
| 700 | 1 | _ | |a Roberson, Erik |b 171 |
| 700 | 1 | _ | |a Love, Marissa Natelson |b 172 |
| 700 | 1 | _ | |a Grossman, Hillel |b 173 |
| 700 | 1 | _ | |a Mitsis, Effie |b 174 |
| 700 | 1 | _ | |a Shah, Raj C |b 175 |
| 700 | 1 | _ | |a deToledo-Morrell, Leyla |b 176 |
| 700 | 1 | _ | |a Duara, Ranjan |b 177 |
| 700 | 1 | _ | |a Varon, Daniel |b 178 |
| 700 | 1 | _ | |a Greig, Maria T |b 179 |
| 700 | 1 | _ | |a Roberts, Peggy |b 180 |
| 700 | 1 | _ | |a Albert, Marilyn |b 181 |
| 700 | 1 | _ | |a Onyike, Chiadi |b 182 |
| 700 | 1 | _ | |a D' Agostino, Daniel |b 183 |
| 700 | 1 | _ | |a Kielb, Stephanie |b 184 |
| 700 | 1 | _ | |a Galvin, James E |b 185 |
| 700 | 1 | _ | |a Cerbone, Brittany |b 186 |
| 700 | 1 | _ | |a Michel, Christina A |b 187 |
| 700 | 1 | _ | |a Pogorelec, Dana M |b 188 |
| 700 | 1 | _ | |a Rusinek, Henry |b 189 |
| 700 | 1 | _ | |a de Leon, Mony J |b 190 |
| 700 | 1 | _ | |a Glodzik, Lidia |b 191 |
| 700 | 1 | _ | |a De Santi, Susan |b 192 |
| 700 | 1 | _ | |a Doraiswamy, P Murali |b 193 |
| 700 | 1 | _ | |a Petrella, Jeffrey R |b 194 |
| 700 | 1 | _ | |a Borges-Neto, Salvador |b 195 |
| 700 | 1 | _ | |a Wong, Terence Z |b 196 |
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| 700 | 1 | _ | |a Wolk, David |b 200 |
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| 700 | 1 | _ | |a Jicha, Greg |b 203 |
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| 700 | 1 | _ | |a Oates, Elizabeth |b 206 |
| 700 | 1 | _ | |a Conrad, Gary |b 207 |
| 700 | 1 | _ | |a Lopez, Oscar L |b 208 |
| 700 | 1 | _ | |a Oakley, MaryAnn |b 209 |
| 700 | 1 | _ | |a Simpson, Donna M |b 210 |
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| 700 | 1 | _ | |a Martin, Kim |b 213 |
| 700 | 1 | _ | |a Makino, Kelly M |b 214 |
| 700 | 1 | _ | |a Ismail, M Saleem |0 P:(DE-HGF)0 |b 215 |
| 700 | 1 | _ | |a Brand, Connie |b 216 |
| 700 | 1 | _ | |a Mulnard, Ruth A |b 217 |
| 700 | 1 | _ | |a Thai, Gaby |b 218 |
| 700 | 1 | _ | |a Mc-Adams-Ortiz, Catherine |b 219 |
| 700 | 1 | _ | |a Womack, Kyle |b 220 |
| 700 | 1 | _ | |a Mathews, Dana |b 221 |
| 700 | 1 | _ | |a Quiceno, Mary |b 222 |
| 700 | 1 | _ | |a Levey, Allan I |b 223 |
| 700 | 1 | _ | |a Lah, James J |b 224 |
| 700 | 1 | _ | |a Cellar, Janet S |b 225 |
| 700 | 1 | _ | |a Burns, Jeffrey M |b 226 |
| 700 | 1 | _ | |a Swerdlow, Russell H |b 227 |
| 700 | 1 | _ | |a Brooks, William M |b 228 |
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| 700 | 1 | _ | |a Tingus, Kathleen |b 230 |
| 700 | 1 | _ | |a Woo, Ellen |b 231 |
| 700 | 1 | _ | |a Silverman, Daniel H S |b 232 |
| 700 | 1 | _ | |a Lu, Po H |b 233 |
| 700 | 1 | _ | |a Bartzokis, George |b 234 |
| 700 | 1 | _ | |a Graff-Radford, Neill R |b 235 |
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| 700 | 1 | _ | |a Matthews, Brandy R |b 241 |
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| 700 | 1 | _ | |a Budson, Andrew E |b 292 |
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| 700 | 1 | _ | |a Johnson, Patricia Lynn |b 294 |
| 700 | 1 | _ | |a Obisesan, Thomas O |b 295 |
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| 700 | 1 | _ | |a Lerner, Alan |b 298 |
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| 700 | 1 | _ | |a Scharre, Douglas W |b 324 |
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| 700 | 1 | _ | |a Weiner, Michael W |b 435 |
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| 700 | 1 | _ | |a Pawluczyk, Sonia |b 437 |
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