001     138121
005     20240321220356.0
024 7 _ |a 10.1093/brain/awv199
|2 doi
024 7 _ |a pmid:26220940
|2 pmid
024 7 _ |a pmc:PMC4643624
|2 pmc
024 7 _ |a 0006-8950
|2 ISSN
024 7 _ |a 1460-2156
|2 ISSN
024 7 _ |a altmetric:4345495
|2 altmetric
037 _ _ |a DZNE-2020-04443
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Toledo, Jon B
|b 0
245 _ _ |a Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects.
260 _ _ |a Oxford
|c 2015
|b Oxford Univ. Press
264 _ 1 |3 online
|2 Crossref
|b Oxford University Press (OUP)
|c 2015-07-27
264 _ 1 |3 print
|2 Crossref
|b Oxford University Press (OUP)
|c 2015-09-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1588244286_17521
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a In a large multicentre sample of cognitively normal subjects, as a function of age, gender and APOE genotype, we studied the frequency of abnormal cerebrospinal fluid levels of Alzheimer's disease biomarkers including: total tau, phosphorylated tau and amyloid-β1-42. Fifteen cohorts from 12 different centres with either enzyme-linked immunosorbent assays or Luminex® measurements were selected for this study. Each centre sent nine new cerebrospinal fluid aliquots that were used to measure total tau, phosphorylated tau and amyloid-β1-42 in the Gothenburg laboratory. Seven centres showed a high correlation with the new Gothenburg measurements; therefore, 10 cohorts from these centres are included in the analyses here (1233 healthy control subjects, 40-84 years old). Amyloid-β amyloid status (negative or positive) and neurodegeneration status (negative or positive) was established based on the pathological cerebrospinal fluid Alzheimer's disease cut-off values for cerebrospinal fluid amyloid-β1-42 and total tau, respectively. While gender did not affect these biomarker values, APOE genotype modified the age-associated changes in cerebrospinal fluid biomarkers such that APOE ε4 carriers showed stronger age-related changes in cerebrospinal fluid phosphorylated tau, total tau and amyloid-β1-42 values and APOE ε2 carriers showed the opposite effect. At 40 years of age, 76% of the subjects were classified as amyloid negative, neurodegeneration negative and their frequency decreased to 32% at 85 years. The amyloid-positive neurodegeneration-negative group remained stable. The amyloid-negative neurodegeneration-positive group frequency increased slowly from 1% at 44 years to 16% at 85 years, but its frequency was not affected by APOE genotype. The amyloid-positive neurodegeneration-positive frequency increased from 1% at 53 years to 28% at 85 years. Abnormally low cerebrospinal fluid amyloid-β1-42 levels were already frequent in midlife and APOE genotype strongly affects the levels of cerebrospinal fluid amyloid-β1-42, phosphorylated tau and total tau across the lifespan without influencing the frequency of subjects with suspected non-amyloid pathology.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
|0 G:(DE-HGF)POF3-344
|c POF3-344
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
650 _ 7 |a Apolipoproteins E
|2 NLM Chemicals
650 _ 7 |a Peptide Fragments
|2 NLM Chemicals
650 _ 7 |a amyloid beta-protein (1-42)
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Age Factors
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Alzheimer Disease: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Alzheimer Disease: genetics
|2 MeSH
650 _ 2 |a Alzheimer Disease: physiopathology
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Analysis of Variance
|2 MeSH
650 _ 2 |a Apolipoproteins E: genetics
|2 MeSH
650 _ 2 |a Cognition: physiology
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: etiology
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a Peptide Fragments: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Severity of Illness Index
|2 MeSH
650 _ 2 |a tau Proteins: cerebrospinal fluid
|2 MeSH
700 1 _ |a Zetterberg, Henrik
|b 1
700 1 _ |a van Harten, Argonde C
|b 2
700 1 _ |a Glodzik, Lidia
|b 3
700 1 _ |a Martinez-Lage, Pablo
|b 4
700 1 _ |a Bocchio-Chiavetto, Luisella
|b 5
700 1 _ |a Rami, Lorena
|b 6
700 1 _ |a Hansson, Oskar
|b 7
700 1 _ |a Sperling, Reisa
|b 8
700 1 _ |a Engelborghs, Sebastiaan
|b 9
700 1 _ |a Osorio, Ricardo S
|b 10
700 1 _ |a Vanderstichele, Hugo
|b 11
700 1 _ |a Vandijck, Manu
|b 12
700 1 _ |a Hampel, Harald
|b 13
700 1 _ |a Teipel, Stefan
|0 P:(DE-2719)2000026
|b 14
|u dzne
700 1 _ |a Moghekar, Abhay
|b 15
700 1 _ |a Albert, Marilyn
|b 16
700 1 _ |a Hu, William T
|b 17
700 1 _ |a Monge Argilés, Jose A
|b 18
700 1 _ |a Gorostidi, Ana
|b 19
700 1 _ |a Teunissen, Charlotte E
|b 20
700 1 _ |a De Deyn, Peter P
|b 21
700 1 _ |a Hyman, Bradley T
|b 22
700 1 _ |a Molinuevo, Jose L
|b 23
700 1 _ |a Frisoni, Giovanni B
|b 24
700 1 _ |a Linazasoro, Gurutz
|b 25
700 1 _ |a de Leon, Mony J
|b 26
700 1 _ |a van der Flier, Wiesje M
|b 27
700 1 _ |a Scheltens, Philip
|b 28
700 1 _ |a Blennow, Kaj
|b 29
700 1 _ |a Shaw, Leslie M
|0 P:(DE-HGF)0
|b 30
700 1 _ |a Trojanowski, John Q
|0 P:(DE-HGF)0
|b 31
|e Corresponding author
700 1 _ |a Initiative, Alzheimer’s Disease Neuroimaging
|b 32
700 1 _ |a Weiner, Michael W
|b 33
700 1 _ |a Aisen, Paul
|b 34
700 1 _ |a Weiner, Michael
|b 35
700 1 _ |a Aisen, Paul
|b 36
700 1 _ |a Petersen, Ronald
|b 37
700 1 _ |a Jack, Clifford R
|b 38
700 1 _ |a Jagust, William
|b 39
700 1 _ |a Trojanowki, John Q
|b 40
700 1 _ |a Toga, Arthur W
|b 41
700 1 _ |a Beckett, Laurel
|b 42
700 1 _ |a Green, Robert C
|b 43
700 1 _ |a Saykin, Andrew J
|b 44
700 1 _ |a Morris, John
|b 45
700 1 _ |a Shaw, Leslie M
|0 P:(DE-HGF)0
|b 46
700 1 _ |a Khachaturian, Zaven
|b 47
700 1 _ |a Sorensen, Greg
|b 48
700 1 _ |a Carrillo, Maria
|b 49
700 1 _ |a Kuller, Lew
|b 50
700 1 _ |a Raichle, Marc
|b 51
700 1 _ |a Paul, Steven
|b 52
700 1 _ |a Davies, Peter
|b 53
700 1 _ |a Fillit, Howard
|b 54
700 1 _ |a Hefti, Franz
|b 55
700 1 _ |a Holtzman, Davie
|b 56
700 1 _ |a Mesulam, M Marcel
|b 57
700 1 _ |a Potter, William
|b 58
700 1 _ |a Snyder, Peter
|b 59
700 1 _ |a Schwartz, Adam
|b 60
700 1 _ |a Green, Robert C
|b 61
700 1 _ |a Montine, Tom
|b 62
700 1 _ |a Petersen, Ronald
|b 63
700 1 _ |a Aisen, Paul
|b 64
700 1 _ |a Thomas, Ronald G
|b 65
700 1 _ |a Donohue, Michael
|b 66
700 1 _ |a Walter, Sarah
|b 67
700 1 _ |a Gessert, Devon
|b 68
700 1 _ |a Sather, Tamie
|b 69
700 1 _ |a Jiminez, Gus
|b 70
700 1 _ |a Balasubramanian, Archana B
|b 71
700 1 _ |a Mason, Jennifer
|b 72
700 1 _ |a Sim, Iris
|b 73
700 1 _ |a Beckett, Laurel
|b 74
700 1 _ |a Harvey, Danielle
|b 75
700 1 _ |a Donohue, Michael
|b 76
700 1 _ |a Jack, Clifford R
|b 77
700 1 _ |a Bernstein, Matthew
|b 78
700 1 _ |a Fox, Nick
|b 79
700 1 _ |a Thompson, Paul
|b 80
700 1 _ |a Schuff, Norbert
|b 81
700 1 _ |a DeCArli, Charles
|b 82
700 1 _ |a Borowski, Bret
|b 83
700 1 _ |a Gunter, Jeff
|b 84
700 1 _ |a Senjem, Matt
|b 85
700 1 _ |a Vemuri, Prashanthi
|b 86
700 1 _ |a Jones, David
|b 87
700 1 _ |a Kantarci, Kejal
|b 88
700 1 _ |a Ward, Chad
|b 89
700 1 _ |a Jagust, William
|b 90
700 1 _ |a Koeppe, Robert A
|b 91
700 1 _ |a Foster, Norm
|b 92
700 1 _ |a Reiman, Eric M
|b 93
700 1 _ |a Chen, Kewei
|b 94
700 1 _ |a Mathis, Chet
|b 95
700 1 _ |a Landau, Susan
|b 96
700 1 _ |a Morris, John C
|b 97
700 1 _ |a Cairns, Nigel J
|b 98
700 1 _ |a Householder, Erin
|b 99
700 1 _ |a Taylor-Reinwald, Lisa
|b 100
700 1 _ |a Shaw, Leslie M
|0 P:(DE-HGF)0
|b 101
700 1 _ |a Trojanowki, John Q
|b 102
700 1 _ |a Lee, Virginia
|b 103
700 1 _ |a Korecka, Magdalena
|b 104
700 1 _ |a Figurski, Michal
|b 105
700 1 _ |a Toga, Arthur W
|b 106
700 1 _ |a Crawford, Karen
|b 107
700 1 _ |a Neu, Scott
|b 108
700 1 _ |a Saykin, Andrew J
|b 109
700 1 _ |a Foroud, Tatiana M
|b 110
700 1 _ |a Potkin, Steven
|b 111
700 1 _ |a Shen, Li
|b 112
700 1 _ |a Faber, Kelley
|b 113
700 1 _ |a Kim, Sungeun
|b 114
700 1 _ |a Nho, Kwangsik
|b 115
700 1 _ |a Weiner, Michael W
|b 116
700 1 _ |a Thal, Lean
|b 117
700 1 _ |a Khachaturian, Zaven
|b 118
700 1 _ |a Thal, Leon
|b 119
700 1 _ |a Buckholtz, Neil
|b 120
700 1 _ |a Weiner, Michael W
|b 121
700 1 _ |a Snyder, Peter J
|b 122
700 1 _ |a Potter, William
|b 123
700 1 _ |a Paul, Steven
|b 124
700 1 _ |a Albert, Marylyn
|b 125
700 1 _ |a Frank, Richard
|b 126
700 1 _ |a Khachaturian, Zaven
|b 127
700 1 _ |a Hsiao, John
|b 128
700 1 _ |a Kaye, Jeffrey
|b 129
700 1 _ |a Quinn, Joseph
|b 130
700 1 _ |a Silbert, Lisa
|b 131
700 1 _ |a Lind, Betty
|b 132
700 1 _ |a Carter, Raina
|b 133
700 1 _ |a Dolen, Sara
|b 134
700 1 _ |a Schneider, Lon S
|b 135
700 1 _ |a Pawluczyk, Sonia
|b 136
700 1 _ |a Beccera, Mauricio
|b 137
700 1 _ |a Teodoro, Liberty
|b 138
700 1 _ |a Spann, Bryan M
|b 139
700 1 _ |a Brewer, James
|b 140
700 1 _ |a Vanderswag, Helen
|b 141
700 1 _ |a Fleisher, Adam
|b 142
700 1 _ |a Heidebrink, Judith L
|b 143
700 1 _ |a Lord, Joanne L
|b 144
700 1 _ |a Petersen, Ronald
|b 145
700 1 _ |a Mason, Sara S
|b 146
700 1 _ |a Albers, Colleen S
|b 147
700 1 _ |a Knopman, David
|0 P:(DE-HGF)0
|b 148
700 1 _ |a Johnson, Kris
|b 149
700 1 _ |a Doody, Rachelle S
|b 150
700 1 _ |a Villanueva-Meyer, Javier
|b 151
700 1 _ |a Chowdhury, Munir
|b 152
700 1 _ |a Rountree, Susan
|b 153
700 1 _ |a Dang, Mimi
|b 154
700 1 _ |a Stern, Yaakov
|b 155
700 1 _ |a Honig, Lawrence S
|b 156
700 1 _ |a Bell, Karen L
|b 157
700 1 _ |a Ances, Beau
|b 158
700 1 _ |a Morris, John C
|b 159
700 1 _ |a Carroll, Maria
|b 160
700 1 _ |a Creech, Mary L
|b 161
700 1 _ |a Franklin, Erin
|b 162
700 1 _ |a Mintun, Mark A
|b 163
700 1 _ |a Schneider, Stacy
|b 164
700 1 _ |a Oliver, Angela
|b 165
700 1 _ |a Marson, Daniel
|b 166
700 1 _ |a Griffith, Randall
|b 167
700 1 _ |a Clark, David
|b 168
700 1 _ |a Geldmacher, David
|b 169
700 1 _ |a Brockington, John
|b 170
700 1 _ |a Roberson, Erik
|b 171
700 1 _ |a Love, Marissa Natelson
|b 172
700 1 _ |a Grossman, Hillel
|b 173
700 1 _ |a Mitsis, Effie
|b 174
700 1 _ |a Shah, Raj C
|b 175
700 1 _ |a deToledo-Morrell, Leyla
|b 176
700 1 _ |a Duara, Ranjan
|b 177
700 1 _ |a Varon, Daniel
|b 178
700 1 _ |a Greig, Maria T
|b 179
700 1 _ |a Roberts, Peggy
|b 180
700 1 _ |a Albert, Marilyn
|b 181
700 1 _ |a Onyike, Chiadi
|b 182
700 1 _ |a D' Agostino, Daniel
|b 183
700 1 _ |a Kielb, Stephanie
|b 184
700 1 _ |a Galvin, James E
|b 185
700 1 _ |a Cerbone, Brittany
|b 186
700 1 _ |a Michel, Christina A
|b 187
700 1 _ |a Pogorelec, Dana M
|b 188
700 1 _ |a Rusinek, Henry
|b 189
700 1 _ |a de Leon, Mony J
|b 190
700 1 _ |a Glodzik, Lidia
|b 191
700 1 _ |a De Santi, Susan
|b 192
700 1 _ |a Doraiswamy, P Murali
|b 193
700 1 _ |a Petrella, Jeffrey R
|b 194
700 1 _ |a Borges-Neto, Salvador
|b 195
700 1 _ |a Wong, Terence Z
|b 196
700 1 _ |a Coleman, Edward
|b 197
700 1 _ |a Arnold, Steven E
|b 198
700 1 _ |a Karlawish, Jason H
|b 199
700 1 _ |a Wolk, David
|b 200
700 1 _ |a Clark, Christopher M
|b 201
700 1 _ |a Smith, Charles D
|b 202
700 1 _ |a Jicha, Greg
|b 203
700 1 _ |a Hardy, Peter
|b 204
700 1 _ |a Sinha, Partha
|b 205
700 1 _ |a Oates, Elizabeth
|b 206
700 1 _ |a Conrad, Gary
|b 207
700 1 _ |a Lopez, Oscar L
|b 208
700 1 _ |a Oakley, MaryAnn
|b 209
700 1 _ |a Simpson, Donna M
|b 210
700 1 _ |a Porsteinsson, Anton P
|b 211
700 1 _ |a Goldstein, Bonnie S
|b 212
700 1 _ |a Martin, Kim
|b 213
700 1 _ |a Makino, Kelly M
|b 214
700 1 _ |a Ismail, M Saleem
|0 P:(DE-HGF)0
|b 215
700 1 _ |a Brand, Connie
|b 216
700 1 _ |a Mulnard, Ruth A
|b 217
700 1 _ |a Thai, Gaby
|b 218
700 1 _ |a Mc-Adams-Ortiz, Catherine
|b 219
700 1 _ |a Womack, Kyle
|b 220
700 1 _ |a Mathews, Dana
|b 221
700 1 _ |a Quiceno, Mary
|b 222
700 1 _ |a Levey, Allan I
|b 223
700 1 _ |a Lah, James J
|b 224
700 1 _ |a Cellar, Janet S
|b 225
700 1 _ |a Burns, Jeffrey M
|b 226
700 1 _ |a Swerdlow, Russell H
|b 227
700 1 _ |a Brooks, William M
|b 228
700 1 _ |a Apostolova, Liana
|b 229
700 1 _ |a Tingus, Kathleen
|b 230
700 1 _ |a Woo, Ellen
|b 231
700 1 _ |a Silverman, Daniel H S
|b 232
700 1 _ |a Lu, Po H
|b 233
700 1 _ |a Bartzokis, George
|b 234
700 1 _ |a Graff-Radford, Neill R
|b 235
700 1 _ |a Parfitt, Francine
|b 236
700 1 _ |a Kendall, Tracy
|b 237
700 1 _ |a Johnson, Heather
|b 238
700 1 _ |a Farlow, Martin R
|b 239
700 1 _ |a Hake, Ann Marie
|b 240
700 1 _ |a Matthews, Brandy R
|b 241
700 1 _ |a Brosch, Jared R
|b 242
700 1 _ |a Herring, Scott
|b 243
700 1 _ |a Hunt, Cynthia
|b 244
700 1 _ |a van Dyck, Christopher H
|b 245
700 1 _ |a Carson, Richard E
|b 246
700 1 _ |a MacAvoy, Martha G
|b 247
700 1 _ |a Varma, Pradeep
|b 248
700 1 _ |a Chertkow, Howard
|b 249
700 1 _ |a Bergman, Howard
|b 250
700 1 _ |a Hosein, Chris
|b 251
700 1 _ |a Black, Sandra
|b 252
700 1 _ |a Stefanovic, Bojana
|b 253
700 1 _ |a Caldwell, Curtis
|b 254
700 1 _ |a Hsiung, Ging-Yuek Robin
|b 255
700 1 _ |a Feldman, Howard
|b 256
700 1 _ |a Mudge, Benita
|b 257
700 1 _ |a Assaly, Michele
|b 258
700 1 _ |a Finger, Elizabeth
|b 259
700 1 _ |a Pasternack, Stephen
|b 260
700 1 _ |a Rachisky, Irina
|b 261
700 1 _ |a Trost, Dick
|b 262
700 1 _ |a Kertesz, Andrew
|b 263
700 1 _ |a Bernick, Charles
|b 264
700 1 _ |a Munic, Donna
|b 265
700 1 _ |a Mesulam, Marek-Marsel
|b 266
700 1 _ |a Lipowski, Kristine
|b 267
700 1 _ |a Weintraub, MaSandra
|b 268
700 1 _ |a Bonakdarpour, Borna
|b 269
700 1 _ |a Kerwin, Diana
|b 270
700 1 _ |a Wu, Chuang-Kuo
|b 271
700 1 _ |a Johnson, Nancy
|b 272
700 1 _ |a Sadowsky, Carl
|b 273
700 1 _ |a Villena, Teresa
|b 274
700 1 _ |a Turner, Raymond Scott
|b 275
700 1 _ |a Johnson, Kathleen
|b 276
700 1 _ |a Reynolds, Brigid
|b 277
700 1 _ |a Sperling, Reisa A
|b 278
700 1 _ |a Johnson, Keith A
|b 279
700 1 _ |a Marshall, Gad
|b 280
700 1 _ |a Yesavage, Jerome
|b 281
700 1 _ |a Taylor, Joy L
|b 282
700 1 _ |a Lane, Barton
|b 283
700 1 _ |a Rosen, Allyson
|b 284
700 1 _ |a Tinklenberg, Jared
|b 285
700 1 _ |a Sabbagh, Marwan N
|b 286
700 1 _ |a Belden, Christine M
|b 287
700 1 _ |a Jacobson, Sandra A
|b 288
700 1 _ |a Sirrel, Sherye A
|b 289
700 1 _ |a Kowall, Neil
|b 290
700 1 _ |a Killiany, Ronald
|b 291
700 1 _ |a Budson, Andrew E
|b 292
700 1 _ |a Norbash, Alexander
|b 293
700 1 _ |a Johnson, Patricia Lynn
|b 294
700 1 _ |a Obisesan, Thomas O
|b 295
700 1 _ |a Wolday, Saba
|b 296
700 1 _ |a Allard, Joanne
|b 297
700 1 _ |a Lerner, Alan
|b 298
700 1 _ |a Ogrocki, Paula
|b 299
700 1 _ |a Tatsuoka, Curtis
|b 300
700 1 _ |a Fatica, Parianne
|b 301
700 1 _ |a Fletcher, Evan
|b 302
700 1 _ |a Maillard, Pauline
|b 303
700 1 _ |a Olichney, John
|b 304
700 1 _ |a DeCarli, Charles
|b 305
700 1 _ |a Carmichael, Owen
|b 306
700 1 _ |a Kittur, Smita
|b 307
700 1 _ |a Borrie, Michael
|b 308
700 1 _ |a Lee, T-Y
|b 309
700 1 _ |a Bartha, Rob
|b 310
700 1 _ |a Asthana, Sanjay
|b 311
700 1 _ |a Carlsson, Cynthia M
|b 312
700 1 _ |a Potkin, Steven G
|b 313
700 1 _ |a Preda, Adrian
|b 314
700 1 _ |a Nguyen, Dana
|b 315
700 1 _ |a Tariot, Pierre
|b 316
700 1 _ |a Burke, Anna
|b 317
700 1 _ |a Trncic, Nadira
|b 318
700 1 _ |a Fleisher, Adam
|b 319
700 1 _ |a Reeder, Stephanie
|b 320
700 1 _ |a Bates, Vernice
|b 321
700 1 _ |a Capote, Horacio
|b 322
700 1 _ |a Rainka, Michelle
|b 323
700 1 _ |a Scharre, Douglas W
|b 324
700 1 _ |a Kataki, Maria
|b 325
700 1 _ |a Adeli, Anahita
|b 326
700 1 _ |a Zimmerman, Earl A
|b 327
700 1 _ |a Celmins, Dzintra
|b 328
700 1 _ |a Brown, Alice D
|b 329
700 1 _ |a Pearlson, Godfrey D
|b 330
700 1 _ |a Blank, Karen
|b 331
700 1 _ |a Anderson, Karen
|b 332
700 1 _ |a Flashman, Laura A
|b 333
700 1 _ |a Seltzer, Marc
|b 334
700 1 _ |a Hynes, Mary L
|b 335
700 1 _ |a Santulli, Robert B
|b 336
700 1 _ |a Sink, Kaycee M
|b 337
700 1 _ |a Gordineer, Leslie
|b 338
700 1 _ |a Williamson, Jeff D
|b 339
700 1 _ |a Garg, Pradeep
|b 340
700 1 _ |a Watkins, Franklin
|b 341
700 1 _ |a Ott, Brian R
|b 342
700 1 _ |a Querfurth, Henry
|b 343
700 1 _ |a Tremont, Geoffrey
|b 344
700 1 _ |a Salloway, Stephen
|b 345
700 1 _ |a Malloy, Paul
|b 346
700 1 _ |a Correia, Stephen
|b 347
700 1 _ |a Rosen, Howard J
|b 348
700 1 _ |a Miller, Bruce L
|b 349
700 1 _ |a Perry, David
|b 350
700 1 _ |a Mintzer, Jacobo
|b 351
700 1 _ |a Spicer, Kenneth
|b 352
700 1 _ |a Bachman, David
|b 353
700 1 _ |a Finger, Elizabether
|b 354
700 1 _ |a Pasternak, Stephen
|b 355
700 1 _ |a Rachinsky, Irina
|b 356
700 1 _ |a Rogers, John
|b 357
700 1 _ |a Kertesz, Andrew
|b 358
700 1 _ |a Drost, Dick
|b 359
700 1 _ |a Pomara, Nunzio
|b 360
700 1 _ |a Hernando, Raymundo
|b 361
700 1 _ |a Sarrael, Antero
|b 362
700 1 _ |a Schultz, Susan K
|b 363
700 1 _ |a Ponto, Laura L Boles
|b 364
700 1 _ |a Shim, Hyungsub
|b 365
700 1 _ |a Smith, Karen Ekstam
|b 366
700 1 _ |a Relkin, Norman
|b 367
700 1 _ |a Chaing, Gloria
|b 368
700 1 _ |a Lin, Michael
|b 369
700 1 _ |a Ravdin, Lisa
|b 370
700 1 _ |a Smith, Amanda
|b 371
700 1 _ |a Raj, Balebail Ashok
|b 372
700 1 _ |a Fargher, Kristin
|b 373
700 1 _ |a Weiner, Michael W
|b 374
700 1 _ |a Aisen, Paul
|b 375
700 1 _ |a Weiner, Michael
|b 376
700 1 _ |a Aisen, Paul
|b 377
700 1 _ |a Petersen, Ronald
|b 378
700 1 _ |a Green, Robert C
|b 379
700 1 _ |a Harvey, Danielle
|b 380
700 1 _ |a Jack, Clifford R
|b 381
700 1 _ |a Jagust, William
|b 382
700 1 _ |a Morris, John C
|b 383
700 1 _ |a Saykin, Andrew J
|b 384
700 1 _ |a Shaw, Leslie M
|0 P:(DE-HGF)0
|b 385
700 1 _ |a Trojanowki, John Q
|b 386
700 1 _ |a Neylan, Thomas
|b 387
700 1 _ |a Grafman, Jordan
|b 388
700 1 _ |a Green, Robert C
|b 389
700 1 _ |a Montine, Tom
|b 390
700 1 _ |a Weiner, Michael
|b 391
700 1 _ |a Petersen, Ronald
|b 392
700 1 _ |a Aisen, Paul
|b 393
700 1 _ |a Thomas, Ronald G
|b 394
700 1 _ |a Donohue, Michael
|b 395
700 1 _ |a Gessert, Devon
|b 396
700 1 _ |a Sather, Tamie
|b 397
700 1 _ |a Davis, Melissa
|b 398
700 1 _ |a Morrison, Rosemary
|b 399
700 1 _ |a Jiminez, Gus
|b 400
700 1 _ |a Neylan, Thomas
|b 401
700 1 _ |a Hayes, Jacqueline
|b 402
700 1 _ |a Finley, Shannon
|b 403
700 1 _ |a Harvey, Danielle
|b 404
700 1 _ |a Donohue, Michael
|b 405
700 1 _ |a Jack, Clifford R
|b 406
700 1 _ |a Bernstein, Matthew
|b 407
700 1 _ |a Borowski, Bret
|b 408
700 1 _ |a Gunter, Jeff
|b 409
700 1 _ |a Senjem, Matt
|b 410
700 1 _ |a Kantarci, Kejal
|b 411
700 1 _ |a Jagust, William
|b 412
700 1 _ |a Koeppe, Robert A
|b 413
700 1 _ |a Foster, Norm
|b 414
700 1 _ |a Reiman, Eric M
|b 415
700 1 _ |a Chen, Kewei
|b 416
700 1 _ |a Landau, Susan
|b 417
700 1 _ |a Morris, John C
|b 418
700 1 _ |a Cairns, Nigel J
|b 419
700 1 _ |a Householder, Erin
|b 420
700 1 _ |a Shaw, Leslie M
|0 P:(DE-HGF)0
|b 421
700 1 _ |a Trojanowki, John Q
|b 422
700 1 _ |a Lee, Virginia
|b 423
700 1 _ |a Korecka, Magdalena
|b 424
700 1 _ |a Figurski, Michal
|b 425
700 1 _ |a Toga, Arthur W
|b 426
700 1 _ |a Crawford, Karen
|b 427
700 1 _ |a Neu, Scott
|b 428
700 1 _ |a Saykin, Andrew J
|b 429
700 1 _ |a Foroud, Tatiana M
|b 430
700 1 _ |a Potkin, Steven
|b 431
700 1 _ |a Shen, Li
|b 432
700 1 _ |a Faber, Kelley
|b 433
700 1 _ |a Kim, Sungeun
|b 434
700 1 _ |a Weiner, Michael W
|b 435
700 1 _ |a Schneider, Lon S
|b 436
700 1 _ |a Pawluczyk, Sonia
|b 437
700 1 _ |a Beccera, Mauricio
|b 438
700 1 _ |a Brewer, James
|b 439
700 1 _ |a Vanderswag, Helen
|b 440
700 1 _ |a Stern, Yaakov
|b 441
700 1 _ |a Honig, Lawrence S
|b 442
700 1 _ |a Bell, Karen L
|b 443
700 1 _ |a Fleischman, Debra
|b 444
700 1 _ |a Arfanakis, Konstantinos
|b 445
700 1 _ |a Shah, Raj C
|b 446
700 1 _ |a Duara, Ranjan
|b 447
700 1 _ |a Varon, Daniel
|b 448
700 1 _ |a Greig, Maria T
|b 449
700 1 _ |a Doraiswamy, P Murali
|b 450
700 1 _ |a Petrella, Jeffrey R
|b 451
700 1 _ |a James, Olga
|b 452
700 1 _ |a Porsteinsson, Anton P
|b 453
700 1 _ |a Goldstein, Bonnie
|b 454
700 1 _ |a Martin, Kimberly S
|b 455
700 1 _ |a Mulnard, Ruth A
|b 456
700 1 _ |a Thai, Gaby
|b 457
700 1 _ |a McAdams-Ortiz, Catherine
|b 458
700 1 _ |a Mintzer, Jacobo
|b 459
700 1 _ |a Massoglia, Dino
|b 460
700 1 _ |a Brawman-Mintzer, Olga
|b 461
700 1 _ |a Sadowsky, Carl
|b 462
700 1 _ |a Martinez, Walter
|b 463
700 1 _ |a Villena, Teresa
|b 464
700 1 _ |a Jagust, William
|b 465
700 1 _ |a Landau, Susan
|b 466
700 1 _ |a Rosen, Howard
|b 467
700 1 _ |a Perry, David
|b 468
700 1 _ |a Turner, Raymond Scott
|b 469
700 1 _ |a Behan, Kelly
|b 470
700 1 _ |a Reynolds, Brigid
|b 471
700 1 _ |a Sperling, Reisa A
|b 472
700 1 _ |a Johnson, Keith A
|b 473
700 1 _ |a Marshall, Gad
|b 474
700 1 _ |a Sabbagh, Marwan N
|b 475
700 1 _ |a Jacobson, Sandra A
|b 476
700 1 _ |a Sirrel, Sherye A
|b 477
700 1 _ |a Obisesan, Thomas O
|b 478
700 1 _ |a Wolday, Saba
|b 479
700 1 _ |a Allard, Joanne
|b 480
700 1 _ |a Johnson, Sterling C
|b 481
700 1 _ |a Fruehling, J Jay
|b 482
700 1 _ |a Harding, Sandra
|b 483
700 1 _ |a Peskind, Elaine R
|b 484
700 1 _ |a Petrie, Eric C
|b 485
700 1 _ |a Li, Gail
|b 486
700 1 _ |a Yesavage, Jerome A
|b 487
700 1 _ |a Taylor, Joy L
|b 488
700 1 _ |a Furst, Ansgar J
|b 489
700 1 _ |a Chao, Steven
|b 490
700 1 _ |a Relkin, Norman
|b 491
700 1 _ |a Chaing, Gloria
|b 492
700 1 _ |a Ravdin, Lisa
|b 493
773 1 8 |a 10.1093/brain/awv199
|b : Oxford University Press (OUP), 2015-07-27
|n 9
|p 2701-2715
|3 journal-article
|2 Crossref
|t Brain
|v 138
|y 2015
|x 0006-8950
773 _ _ |a 10.1093/brain/awv199
|g Vol. 138, no. Pt 9, p. 2701 - 2715
|0 PERI:(DE-600)1474117-9
|n 9
|q 138:Pt 9<2701 - 2715
|p 2701-2715
|t Brain
|v 138
|y 2015
|x 0006-8950
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643624
909 C O |o oai:pub.dzne.de:138121
|p VDB
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 14
|6 P:(DE-2719)2000026
913 1 _ |a DE-HGF
|b Forschungsbereich Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-344
|2 G:(DE-HGF)POF3-300
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2015
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b BRAIN : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1110
|2 StatID
|b Current Contents - Clinical Medicine
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a IF >= 10
|0 StatID:(DE-HGF)9910
|2 StatID
|b BRAIN : 2017
920 1 _ |0 I:(DE-2719)1510100
|k Clinical Dementia Research Rostock /Greifswald
|l Clinical Dementia Research Rostock /Greifswald
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1510100
980 _ _ |a UNRESTRICTED
999 C 5 |a 10.1001/archneur.65.11.1509
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/archneur.65.11.1509
999 C 5 |a 10.1056/NEJMoa1202753
|9 -- missing cx lookup --
|2 Crossref
|o 10.1056/NEJMoa1202753
999 C 5 |a 10.1097/WAD.0000000000000025
|9 -- missing cx lookup --
|2 Crossref
|o 10.1097/WAD.0000000000000025
999 C 5 |a 10.1007/s00401-010-0789-4
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00401-010-0789-4
999 C 5 |a 10.1007/s00401-014-1349-0
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00401-014-1349-0
999 C 5 |a 10.1001/archneurol.2010.179
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/archneurol.2010.179
999 C 5 |a 10.1001/archneurol.2011.105
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/archneurol.2011.105
999 C 5 |a 10.1126/scitranslmed.3007901
|9 -- missing cx lookup --
|2 Crossref
|o 10.1126/scitranslmed.3007901
999 C 5 |a 10.1016/j.neurobiolaging.2007.08.019
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neurobiolaging.2007.08.019
999 C 5 |a 10.1136/jnnp.2006.100529
|9 -- missing cx lookup --
|2 Crossref
|o 10.1136/jnnp.2006.100529
999 C 5 |a 10.1073/pnas.1434398100
|9 -- missing cx lookup --
|2 Crossref
|o 10.1073/pnas.1434398100
999 C 5 |a 10.3233/JAD-2010-100207
|9 -- missing cx lookup --
|2 Crossref
|o 10.3233/JAD-2010-100207
999 C 5 |a 10.1073/pnas.151254698
|9 -- missing cx lookup --
|2 Crossref
|o 10.1073/pnas.151254698
999 C 5 |a 10.1016/j.jalz.2011.10.007
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.jalz.2011.10.007
999 C 5 |a 10.1016/0009-8981(87)90151-3
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/0009-8981(87)90151-3
999 C 5 |a 10.1001/archneurol.2012.26
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/archneurol.2012.26
999 C 5 |a 10.1016/S1474-4422(12)70291-0
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/S1474-4422(12)70291-0
999 C 5 |a 10.1002/ana.22628
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/ana.22628
999 C 5 |a 10.1212/WNL.0b013e3182840bbe
|9 -- missing cx lookup --
|2 Crossref
|o 10.1212/WNL.0b013e3182840bbe
999 C 5 |a 10.1212/01.wnl.0000435556.21319.e4
|9 -- missing cx lookup --
|2 Crossref
|o 10.1212/01.wnl.0000435556.21319.e4
999 C 5 |a 10.1001/jamaneurol.2014.4821
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/jamaneurol.2014.4821
999 C 5 |a 10.1016/S1474-4422(14)70194-2
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/S1474-4422(14)70194-2
999 C 5 |a 10.1007/s00401-015-1407-2
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00401-015-1407-2
999 C 5 |a 10.1007/s00702-014-1288-x
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00702-014-1288-x
999 C 5 |y 2013
|2 Crossref
|o Kang 2013
999 C 5 |a 10.1373/clinchem.2013.202937
|9 -- missing cx lookup --
|2 Crossref
|o 10.1373/clinchem.2013.202937
999 C 5 |a 10.1007/s00401-013-1157-y
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00401-013-1157-y
999 C 5 |a 10.1002/ana.23908
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/ana.23908
999 C 5 |a 10.1001/jamapsychiatry.2014.1060
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/jamapsychiatry.2014.1060
999 C 5 |a 10.3233/JAD-2012-121246
|9 -- missing cx lookup --
|2 Crossref
|o 10.3233/JAD-2012-121246
999 C 5 |a 10.1001/jamaneurol.2014.445
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/jamaneurol.2014.445
999 C 5 |a 10.1093/brain/awu367
|9 -- missing cx lookup --
|2 Crossref
|o 10.1093/brain/awu367
999 C 5 |a 10.1212/01.wnl.0000435558.98447.17
|9 -- missing cx lookup --
|2 Crossref
|o 10.1212/01.wnl.0000435558.98447.17
999 C 5 |a 10.1007/s00401-011-0910-3
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00401-011-0910-3
999 C 5 |a 10.1016/j.neurobiolaging.2013.08.007
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neurobiolaging.2013.08.007
999 C 5 |a 10.1001/jamaneurol.2014.1358
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/jamaneurol.2014.1358
999 C 5 |a 10.1016/j.jalz.2011.10.003
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.jalz.2011.10.003
999 C 5 |a 10.1001/archneur.63.7.936
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/archneur.63.7.936
999 C 5 |a 10.1186/s13195-014-0082-1
|9 -- missing cx lookup --
|2 Crossref
|o 10.1186/s13195-014-0082-1
999 C 5 |a 10.1016/S1474-4422(12)70228-4
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/S1474-4422(12)70228-4
999 C 5 |a 10.1002/ana.21610
|9 -- missing cx lookup --
|2 Crossref
|o 10.1002/ana.21610
999 C 5 |a 10.1093/clinchem/47.10.1776
|9 -- missing cx lookup --
|2 Crossref
|o 10.1093/clinchem/47.10.1776
999 C 5 |a 10.1159/000068478
|9 -- missing cx lookup --
|2 Crossref
|o 10.1159/000068478
999 C 5 |a 10.2174/156720510791383796
|9 -- missing cx lookup --
|2 Crossref
|o 10.2174/156720510791383796
999 C 5 |a 10.1159/000105017
|9 -- missing cx lookup --
|2 Crossref
|o 10.1159/000105017
999 C 5 |a 10.1212/01.WNL.0000046581.81650.D0
|9 -- missing cx lookup --
|2 Crossref
|o 10.1212/01.WNL.0000046581.81650.D0
999 C 5 |a 10.1001/archneurol.2008.596
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/archneurol.2008.596
999 C 5 |a 10.1016/j.neurobiolaging.2013.09.029
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.neurobiolaging.2013.09.029
999 C 5 |a 10.1093/brain/awt188
|9 -- missing cx lookup --
|2 Crossref
|o 10.1093/brain/awt188
999 C 5 |a 10.1001/jamaneurol.2014.4829
|9 -- missing cx lookup --
|2 Crossref
|o 10.1001/jamaneurol.2014.4829
999 C 5 |a 10.1007/s00401-012-0983-7
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00401-012-0983-7
999 C 5 |a 10.1186/2051-5960-1-65
|9 -- missing cx lookup --
|2 Crossref
|o 10.1186/2051-5960-1-65
999 C 5 |a 10.1016/j.jalz.2013.06.003
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.jalz.2013.06.003
999 C 5 |a 10.1186/2051-5960-2-26
|9 -- missing cx lookup --
|2 Crossref
|o 10.1186/2051-5960-2-26
999 C 5 |a 10.1007/s00401-013-1151-4
|9 -- missing cx lookup --
|2 Crossref
|o 10.1007/s00401-013-1151-4
999 C 5 |a 10.3233/JAD-132306
|9 -- missing cx lookup --
|2 Crossref
|o 10.3233/JAD-132306
999 C 5 |a 10.1016/j.jalz.2012.08.004
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.jalz.2012.08.004
999 C 5 |2 Crossref
|o
999 C 5 |a 10.1016/S1474-4422(13)70044-9
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/S1474-4422(13)70044-9
999 C 5 |a 10.3233/JAD-2012-120082
|9 -- missing cx lookup --
|2 Crossref
|o 10.3233/JAD-2012-120082
999 C 5 |a 10.1016/j.jalz.2013.05.1769
|9 -- missing cx lookup --
|2 Crossref
|o 10.1016/j.jalz.2013.05.1769


LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21