Journal Article

DZNE-2020-04518

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep.

Staresina, B. P. (Corresponding author) ; Bergmann, T. O. ; Bonnefond, M. ; van der Meij, R. ; Jensen, O. ; Deuker, L. ; Elger, C. E. ; Axmacher, N.DZNE* ; Fell, J.

2015
Nature Publ. Group58142 London

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Please use a persistent id in citations: doi:10.1038/nn.4119

Abstract: During systems-level consolidation, mnemonic representations initially reliant on the hippocampus are thought to migrate to neocortical sites for more permanent storage, with an eminent role of sleep for facilitating this information transfer. Mechanistically, consolidation processes have been hypothesized to rely on systematic interactions between the three cardinal neuronal oscillations characterizing non-rapid eye movement (NREM) sleep. Under global control of de- and hyperpolarizing slow oscillations (SOs), sleep spindles may cluster hippocampal ripples for a precisely timed transfer of local information to the neocortex. We used direct intracranial electroencephalogram recordings from human epilepsy patients during natural sleep to test the assumption that SOs, spindles and ripples are functionally coupled in the hippocampus. Employing cross-frequency phase-amplitude coupling analyses, we found that spindles were modulated by the up-state of SOs. Notably, spindles were found to in turn cluster ripples in their troughs, providing fine-tuned temporal frames for the hypothesized transfer of hippocampal memory traces.

Keyword(s): Adult (MeSH) ; Electroencephalography: methods (MeSH) ; Epilepsy: physiopathology (MeSH) ; Female (MeSH) ; Hippocampus: physiology (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Memory: physiology (MeSH) ; Neocortex: physiology (MeSH) ; Sleep: physiology (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Memory and Sleep (AG Axmacher)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2015

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; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; IF >= 30 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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