Journal Article (Review Article)

DZNE-2020-04594

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tau in physiology and pathology.

Wang, Y. (First author)DZNE* ; Mandelkow, E. (Last author)DZNE*

2016
Nature Publ. Group London

This record in other databases:    

Please use a persistent id in citations: doi:10.1038/nrn.2015.1

Abstract: Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is highly soluble and shows little tendency for aggregation. However, tau aggregation is characteristic of several neurodegenerative diseases known as tauopathies. The mechanisms underlying tau pathology and tau-mediated neurodegeneration are debated, but considerable progress has been made in the field of tau research in recent years, including the identification of new physiological roles for tau in the brain. Here, we review the expression, post-translational modifications and functions of tau in physiology and in pathophysiology.

Keyword(s): Animals (MeSH) ; Humans (MeSH) ; Phosphorylation: genetics (MeSH) ; Protein Processing, Post-Translational (MeSH) ; Tauopathies: metabolism (MeSH) ; Tauopathies: pathology (MeSH) ; tau Proteins: metabolism (MeSH) ; tau Proteins

---

Contributing Institute(s):

1. Structural Principles of Neurodegeneration (AG Mandelkow 1)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2016

---

Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 30 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

---