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000138284 0247_ $$2doi$$a10.1177/1091581815602252
000138284 0247_ $$2pmid$$apmid:26405269
000138284 0247_ $$2ISSN$$a0730-0913
000138284 0247_ $$2ISSN$$a1091-5818
000138284 0247_ $$2ISSN$$a1092-874X
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000138284 037__ $$aDZNE-2020-04606
000138284 041__ $$aEnglish
000138284 082__ $$a610
000138284 1001_ $$0P:(DE-2719)2813308$$aHöllerhage, Matthias$$b0$$eFirst author$$udzne
000138284 245__ $$aNeurotoxicity of Dietary Supplements from Annonaceae Species.
000138284 260__ $$aLondon$$bSage$$c2015
000138284 264_1 $$2Crossref$$3online$$bSAGE Publications$$c2015-09-24
000138284 264_1 $$2Crossref$$3print$$bSAGE Publications$$c2015-11-01
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000138284 3367_ $$2BibTeX$$aARTICLE
000138284 3367_ $$2ORCID$$aJOURNAL_ARTICLE
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000138284 520__ $$aDietary supplements containing plant materials of Annonaceae species (Annona muricata L., A. squamosa L., A. mucosa JACQ., A. squamosa × cherimola Mabb.) were extracted by hot, pressurized ethyl acetate and analyzed for their effect in vitro on Lund human mesencephalic neurons. Cell viability was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and cell death was determined by lactate dehydrogenase levels. Three supplements strongly decreased the cell viability at extract concentrations of 1 µg/mL, of which 1 decreased cell viability at 0.1 µg/µL. Also, strong neuronal toxicities of these supplements were found. Cell death was observed at concentrations of 10 µg/mL. The degree of toxicity was comparable to the ones found in Annonaceous fruit extracts. Two fruit pulps of Annonaceae (A. muricata and A. squamosa) showed a reduction in cell viability at lower concentrations. The fruit pulp extract of A. muricata revealed the strongest neurotoxic effect, with 67% cell death at a concentration of 1 µg/mL. A high reduction in cell viability coupled with pronounced cell death was found at 0.1 µg/mL for an Annonaceous seed extract. These results demonstrate that the intake of dietary supplements containing plant material from Annonaceae may be hazardous to health in terms of neurotoxicity.
000138284 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
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000138284 650_7 $$2NLM Chemicals$$aPlant Extracts
000138284 650_7 $$2NLM Chemicals$$aTetrazolium Salts
000138284 650_7 $$2NLM Chemicals$$aThiazoles
000138284 650_7 $$0EC 1.1.1.27$$2NLM Chemicals$$aL-Lactate Dehydrogenase
000138284 650_7 $$0EUY85H477I$$2NLM Chemicals$$athiazolyl blue
000138284 650_2 $$2MeSH$$aAnnonaceae: toxicity
000138284 650_2 $$2MeSH$$aCell Survival: drug effects
000138284 650_2 $$2MeSH$$aCells, Cultured
000138284 650_2 $$2MeSH$$aDietary Supplements: toxicity
000138284 650_2 $$2MeSH$$aFruit: chemistry
000138284 650_2 $$2MeSH$$aFruit: toxicity
000138284 650_2 $$2MeSH$$aHumans
000138284 650_2 $$2MeSH$$aL-Lactate Dehydrogenase: analysis
000138284 650_2 $$2MeSH$$aL-Lactate Dehydrogenase: metabolism
000138284 650_2 $$2MeSH$$aMesencephalon: cytology
000138284 650_2 $$2MeSH$$aMesencephalon: drug effects
000138284 650_2 $$2MeSH$$aNeurons: drug effects
000138284 650_2 $$2MeSH$$aNeurotoxicity Syndromes: pathology
000138284 650_2 $$2MeSH$$aPlant Extracts: toxicity
000138284 650_2 $$2MeSH$$aSeeds: chemistry
000138284 650_2 $$2MeSH$$aSeeds: toxicity
000138284 650_2 $$2MeSH$$aTetrazolium Salts
000138284 650_2 $$2MeSH$$aThiazoles
000138284 7001_ $$0P:(DE-2719)2810437$$aRösler, Thomas W$$b1$$udzne
000138284 7001_ $$0P:(DE-2719)2810669$$aBerjas, Magda$$b2$$udzne
000138284 7001_ $$aLuo, Rensheng$$b3
000138284 7001_ $$aTran, Kevin$$b4
000138284 7001_ $$aRichards, Kristy M$$b5
000138284 7001_ $$aSabaa-Srur, Armando U$$b6
000138284 7001_ $$aMaia, José Guilherme S$$b7
000138284 7001_ $$aMoraes, Maria Rosa de$$b8
000138284 7001_ $$aGodoy, Helena T$$b9
000138284 7001_ $$0P:(DE-2719)2811373$$aHöglinger, Günter U$$b10$$udzne
000138284 7001_ $$0P:(DE-HGF)0$$aSmith, Robert E$$b11$$eCorresponding author
000138284 77318 $$2Crossref$$3journal-article$$a10.1177/1091581815602252$$b : SAGE Publications, 2015-09-24$$n6$$p543-550$$tInternational Journal of Toxicology$$v34$$x1091-5818$$y2015
000138284 773__ $$0PERI:(DE-600)1500682-7$$a10.1177/1091581815602252$$gVol. 34, no. 6, p. 543 - 550$$n6$$p543-550$$q34:6<543 - 550$$tInternational journal of toxicology$$v34$$x1091-5818$$y2015
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