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| 001 | 138284 | ||
| 005 | 20250318135756.0 | ||
| 024 | 7 | _ | |a 10.1177/1091581815602252 |2 doi |
| 024 | 7 | _ | |a pmid:26405269 |2 pmid |
| 024 | 7 | _ | |a 0730-0913 |2 ISSN |
| 024 | 7 | _ | |a 1091-5818 |2 ISSN |
| 024 | 7 | _ | |a 1092-874X |2 ISSN |
| 024 | 7 | _ | |a altmetric:4880268 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-04606 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Höllerhage, Matthias |0 P:(DE-2719)2813308 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Neurotoxicity of Dietary Supplements from Annonaceae Species. |
| 260 | _ | _ | |a London |c 2015 |b Sage |
| 264 | _ | 1 | |3 online |2 Crossref |b SAGE Publications |c 2015-09-24 |
| 264 | _ | 1 | |3 print |2 Crossref |b SAGE Publications |c 2015-11-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1742302637_1354 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Dietary supplements containing plant materials of Annonaceae species (Annona muricata L., A. squamosa L., A. mucosa JACQ., A. squamosa × cherimola Mabb.) were extracted by hot, pressurized ethyl acetate and analyzed for their effect in vitro on Lund human mesencephalic neurons. Cell viability was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and cell death was determined by lactate dehydrogenase levels. Three supplements strongly decreased the cell viability at extract concentrations of 1 µg/mL, of which 1 decreased cell viability at 0.1 µg/µL. Also, strong neuronal toxicities of these supplements were found. Cell death was observed at concentrations of 10 µg/mL. The degree of toxicity was comparable to the ones found in Annonaceous fruit extracts. Two fruit pulps of Annonaceae (A. muricata and A. squamosa) showed a reduction in cell viability at lower concentrations. The fruit pulp extract of A. muricata revealed the strongest neurotoxic effect, with 67% cell death at a concentration of 1 µg/mL. A high reduction in cell viability coupled with pronounced cell death was found at 0.1 µg/mL for an Annonaceous seed extract. These results demonstrate that the intake of dietary supplements containing plant material from Annonaceae may be hazardous to health in terms of neurotoxicity. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2015-09-24 |2 Crossref |u http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Plant Extracts |2 NLM Chemicals |
| 650 | _ | 7 | |a Tetrazolium Salts |2 NLM Chemicals |
| 650 | _ | 7 | |a Thiazoles |2 NLM Chemicals |
| 650 | _ | 7 | |a L-Lactate Dehydrogenase |0 EC 1.1.1.27 |2 NLM Chemicals |
| 650 | _ | 7 | |a thiazolyl blue |0 EUY85H477I |2 NLM Chemicals |
| 650 | _ | 2 | |a Annonaceae: toxicity |2 MeSH |
| 650 | _ | 2 | |a Cell Survival: drug effects |2 MeSH |
| 650 | _ | 2 | |a Cells, Cultured |2 MeSH |
| 650 | _ | 2 | |a Dietary Supplements: toxicity |2 MeSH |
| 650 | _ | 2 | |a Fruit: chemistry |2 MeSH |
| 650 | _ | 2 | |a Fruit: toxicity |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a L-Lactate Dehydrogenase: analysis |2 MeSH |
| 650 | _ | 2 | |a L-Lactate Dehydrogenase: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mesencephalon: cytology |2 MeSH |
| 650 | _ | 2 | |a Mesencephalon: drug effects |2 MeSH |
| 650 | _ | 2 | |a Neurons: drug effects |2 MeSH |
| 650 | _ | 2 | |a Neurotoxicity Syndromes: pathology |2 MeSH |
| 650 | _ | 2 | |a Plant Extracts: toxicity |2 MeSH |
| 650 | _ | 2 | |a Seeds: chemistry |2 MeSH |
| 650 | _ | 2 | |a Seeds: toxicity |2 MeSH |
| 650 | _ | 2 | |a Tetrazolium Salts |2 MeSH |
| 650 | _ | 2 | |a Thiazoles |2 MeSH |
| 700 | 1 | _ | |a Rösler, Thomas W |0 P:(DE-2719)2810437 |b 1 |u dzne |
| 700 | 1 | _ | |a Berjas, Magda |0 P:(DE-2719)2810669 |b 2 |u dzne |
| 700 | 1 | _ | |a Luo, Rensheng |b 3 |
| 700 | 1 | _ | |a Tran, Kevin |b 4 |
| 700 | 1 | _ | |a Richards, Kristy M |b 5 |
| 700 | 1 | _ | |a Sabaa-Srur, Armando U |b 6 |
| 700 | 1 | _ | |a Maia, José Guilherme S |b 7 |
| 700 | 1 | _ | |a Moraes, Maria Rosa de |b 8 |
| 700 | 1 | _ | |a Godoy, Helena T |b 9 |
| 700 | 1 | _ | |a Höglinger, Günter U |0 P:(DE-2719)2811373 |b 10 |u dzne |
| 700 | 1 | _ | |a Smith, Robert E |0 P:(DE-HGF)0 |b 11 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1177/1091581815602252 |b : SAGE Publications, 2015-09-24 |n 6 |p 543-550 |3 journal-article |2 Crossref |t International Journal of Toxicology |v 34 |y 2015 |x 1091-5818 |
| 773 | _ | _ | |a 10.1177/1091581815602252 |g Vol. 34, no. 6, p. 543 - 550 |0 PERI:(DE-600)1500682-7 |n 6 |q 34:6<543 - 550 |p 543-550 |t International journal of toxicology |v 34 |y 2015 |x 1091-5818 |
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