%0 Journal Article
%A Krüger, Lars
%A Mandelkow, Eva Maria
%T Tau neurotoxicity and rescue in animal models of human Tauopathies.
%J Current opinion in neurobiology
%V 36
%@ 0959-4388
%C Philadelphia, Pa.
%I Current Biology
%M DZNE-2020-04704
%P 52-58
%D 2016
%X Pathological Tau is a hallmark of various neuronal disorders and spreads in the brain of Alzheimer patients in a well-defined manner. Beside Tau's main function in stabilizing microtubules for axonal transport, a variety of novel functions for neurons and glia have emerged recently. Tau regulates the susceptibility to hyperexcitation and plays a role in neuron-glia contact formation. Studies implicate soluble oligomeric species of Tau, rather than insoluble aggregates, as more detrimental to proper neuronal function. Tau is not exclusively intracellular; instead Tau can be released into the extracellular space. This has led to the hypothesis of a prion-disease like mechanism to explain the stereotypical progression of Tau. Targeting pathological Tau with antibodies or aggregation inhibitors may help to prevent pathology.
%K Animals
%K Antibodies: pharmacology
%K Brain: metabolism
%K Brain: physiopathology
%K Disease Models, Animal
%K Disease Susceptibility
%K Humans
%K Mice
%K Presynaptic Terminals: metabolism
%K Protein Aggregates: drug effects
%K Protein Aggregation, Pathological: metabolism
%K Protein Aggregation, Pathological: physiopathology
%K Tauopathies: metabolism
%K Tauopathies: physiopathology
%K tau Proteins: metabolism
%K Antibodies (NLM Chemicals)
%K Protein Aggregates (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:26431808
%R 10.1016/j.conb.2015.09.004
%U https://pub.dzne.de/record/138382