Journal Article (Review Article)

DZNE-2020-04704

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tau neurotoxicity and rescue in animal models of human Tauopathies.

Krüger, L. (First author)DZNE* ; Mandelkow, E. M. (Last author)DZNE*

2016
Current Biology Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1016/j.conb.2015.09.004

Abstract: Pathological Tau is a hallmark of various neuronal disorders and spreads in the brain of Alzheimer patients in a well-defined manner. Beside Tau's main function in stabilizing microtubules for axonal transport, a variety of novel functions for neurons and glia have emerged recently. Tau regulates the susceptibility to hyperexcitation and plays a role in neuron-glia contact formation. Studies implicate soluble oligomeric species of Tau, rather than insoluble aggregates, as more detrimental to proper neuronal function. Tau is not exclusively intracellular; instead Tau can be released into the extracellular space. This has led to the hypothesis of a prion-disease like mechanism to explain the stereotypical progression of Tau. Targeting pathological Tau with antibodies or aggregation inhibitors may help to prevent pathology.

Keyword(s): Animals (MeSH) ; Antibodies: pharmacology (MeSH) ; Brain: metabolism (MeSH) ; Brain: physiopathology (MeSH) ; Disease Models, Animal (MeSH) ; Disease Susceptibility (MeSH) ; Humans (MeSH) ; Mice (MeSH) ; Presynaptic Terminals: metabolism (MeSH) ; Protein Aggregates: drug effects (MeSH) ; Protein Aggregation, Pathological: metabolism (MeSH) ; Protein Aggregation, Pathological: physiopathology (MeSH) ; Tauopathies: metabolism (MeSH) ; Tauopathies: physiopathology (MeSH) ; tau Proteins: metabolism (MeSH) ; Antibodies ; Protein Aggregates ; tau Proteins

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Contributing Institute(s):

1. Technology Transfer and Industry Collaborations Unit (TT)
2. Cell and Animal Models of Neurodegeneration (AG Mandelkow 2)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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