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000138382 041__ $$aEnglish
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000138382 1001_ $$0P:(DE-2719)2810335$$aKrüger, Lars$$b0$$eFirst author
000138382 245__ $$aTau neurotoxicity and rescue in animal models of human Tauopathies.
000138382 260__ $$aPhiladelphia, Pa.$$bCurrent Biology$$c2016
000138382 264_1 $$2Crossref$$3print$$bElsevier BV$$c2016-02-01
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000138382 520__ $$aPathological Tau is a hallmark of various neuronal disorders and spreads in the brain of Alzheimer patients in a well-defined manner. Beside Tau's main function in stabilizing microtubules for axonal transport, a variety of novel functions for neurons and glia have emerged recently. Tau regulates the susceptibility to hyperexcitation and plays a role in neuron-glia contact formation. Studies implicate soluble oligomeric species of Tau, rather than insoluble aggregates, as more detrimental to proper neuronal function. Tau is not exclusively intracellular; instead Tau can be released into the extracellular space. This has led to the hypothesis of a prion-disease like mechanism to explain the stereotypical progression of Tau. Targeting pathological Tau with antibodies or aggregation inhibitors may help to prevent pathology.
000138382 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000138382 650_7 $$2NLM Chemicals$$aAntibodies
000138382 650_7 $$2NLM Chemicals$$aProtein Aggregates
000138382 650_7 $$2NLM Chemicals$$atau Proteins
000138382 650_2 $$2MeSH$$aAnimals
000138382 650_2 $$2MeSH$$aAntibodies: pharmacology
000138382 650_2 $$2MeSH$$aBrain: metabolism
000138382 650_2 $$2MeSH$$aBrain: physiopathology
000138382 650_2 $$2MeSH$$aDisease Models, Animal
000138382 650_2 $$2MeSH$$aDisease Susceptibility
000138382 650_2 $$2MeSH$$aHumans
000138382 650_2 $$2MeSH$$aMice
000138382 650_2 $$2MeSH$$aPresynaptic Terminals: metabolism
000138382 650_2 $$2MeSH$$aProtein Aggregates: drug effects
000138382 650_2 $$2MeSH$$aProtein Aggregation, Pathological: metabolism
000138382 650_2 $$2MeSH$$aProtein Aggregation, Pathological: physiopathology
000138382 650_2 $$2MeSH$$aTauopathies: metabolism
000138382 650_2 $$2MeSH$$aTauopathies: physiopathology
000138382 650_2 $$2MeSH$$atau Proteins: metabolism
000138382 7001_ $$0P:(DE-2719)2541658$$aMandelkow, Eva Maria$$b1$$eLast author
000138382 77318 $$2Crossref$$3journal-article$$a10.1016/j.conb.2015.09.004$$b : Elsevier BV, 2016-02-01$$p52-58$$tCurrent Opinion in Neurobiology$$v36$$x0959-4388$$y2016
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