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000138393 037__ $$aDZNE-2020-04715
000138393 041__ $$aEnglish
000138393 082__ $$a610
000138393 1001_ $$aCastillo-Gomez, Esther$$b0
000138393 245__ $$aThe brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1.
000138393 260__ $$aHoboken, NJ$$bWiley-Blackwell$$c2016
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000138393 520__ $$aAutoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) are highly seroprevalent in health and disease. Symptomatic relevance may arise upon compromised blood-brain barrier (BBB). However, it remained unknown whether circulating NMDAR1 AB appear in the cerebrospinal fluid (CSF). Of n = 271 subjects with CSF-serum pairs, 26 were NMDAR1 AB seropositive, but only 1 was CSF positive. Contrariwise, tetanus AB (non-brain-binding) were present in serum and CSF of all subjects, with CSF levels higher upon BBB dysfunction. Translational mouse experiments proved the hypothesis that the brain acts as an 'immunoprecipitator'; simultaneous injection of NMDAR1 AB and the non-brain-binding green fluorescent protein AB resulted in high detectability of the former in brain and the latter in CSF.
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000138393 650_7 $$2NLM Chemicals$$aAutoantibodies
000138393 650_7 $$2NLM Chemicals$$aNR1 NMDA receptor
000138393 650_7 $$2NLM Chemicals$$aReceptors, N-Methyl-D-Aspartate
000138393 650_2 $$2MeSH$$aAdult
000138393 650_2 $$2MeSH$$aAnimals
000138393 650_2 $$2MeSH$$aAutoantibodies: blood
000138393 650_2 $$2MeSH$$aAutoantibodies: cerebrospinal fluid
000138393 650_2 $$2MeSH$$aBlood-Brain Barrier: physiopathology
000138393 650_2 $$2MeSH$$aBrain: immunology
000138393 650_2 $$2MeSH$$aFemale
000138393 650_2 $$2MeSH$$aHumans
000138393 650_2 $$2MeSH$$aMale
000138393 650_2 $$2MeSH$$aMice
000138393 650_2 $$2MeSH$$aMice, Inbred C57BL
000138393 650_2 $$2MeSH$$aMiddle Aged
000138393 650_2 $$2MeSH$$aMultiple Sclerosis: blood
000138393 650_2 $$2MeSH$$aMultiple Sclerosis: cerebrospinal fluid
000138393 650_2 $$2MeSH$$aReceptors, N-Methyl-D-Aspartate: immunology
000138393 650_2 $$2MeSH$$aSeroepidemiologic Studies
000138393 7001_ $$aKästner, Anne$$b1
000138393 7001_ $$aSteiner, Johann$$b2
000138393 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b3$$udzne
000138393 7001_ $$aHettling, Bilke$$b4
000138393 7001_ $$aPoggi, Giulia$$b5
000138393 7001_ $$aOstehr, Kristin$$b6
000138393 7001_ $$aUhr, Manfred$$b7
000138393 7001_ $$aAsif, Abdul R$$b8
000138393 7001_ $$aMatzke, Mike$$b9
000138393 7001_ $$aSchmidt, Ulrike$$b10
000138393 7001_ $$aPfander, Viktoria$$b11
000138393 7001_ $$aHammer, Christian$$b12
000138393 7001_ $$aSchulz, Thomas F$$b13
000138393 7001_ $$aBinder, Lutz$$b14
000138393 7001_ $$aStöcker, Winfried$$b15
000138393 7001_ $$aWeber, Frank$$b16
000138393 7001_ $$0P:(DE-HGF)0$$aEhrenreich, Hannelore$$b17$$eCorresponding author
000138393 77318 $$2Crossref$$3journal-article$$a10.1002/ana.24545$$b : Wiley, 2015-12-02$$n1$$p144-151$$tAnnals of Neurology$$v79$$x0364-5134$$y2015
000138393 773__ $$0PERI:(DE-600)2037912-2$$a10.1002/ana.24545$$gVol. 79, no. 1, p. 144 - 151$$n1$$p144-151$$q79:1<144 - 151$$tAnnals of neurology$$v79$$x0364-5134$$y2016
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