Journal Article

DZNE-2020-04715

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1.

Castillo-Gomez, E. ; Kästner, A. ; Steiner, J. ; Schneider, A.DZNE* ; Hettling, B. ; Poggi, G. ; Ostehr, K. ; Uhr, M. ; Asif, A. R. ; Matzke, M. ; Schmidt, U. ; Pfander, V. ; Hammer, C. ; Schulz, T. F. ; Binder, L. ; Stöcker, W. ; Weber, F. ; Ehrenreich, H. (Corresponding author)

2016
Wiley-Blackwell Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/ana.24545

Abstract: Autoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) are highly seroprevalent in health and disease. Symptomatic relevance may arise upon compromised blood-brain barrier (BBB). However, it remained unknown whether circulating NMDAR1 AB appear in the cerebrospinal fluid (CSF). Of n = 271 subjects with CSF-serum pairs, 26 were NMDAR1 AB seropositive, but only 1 was CSF positive. Contrariwise, tetanus AB (non-brain-binding) were present in serum and CSF of all subjects, with CSF levels higher upon BBB dysfunction. Translational mouse experiments proved the hypothesis that the brain acts as an 'immunoprecipitator'; simultaneous injection of NMDAR1 AB and the non-brain-binding green fluorescent protein AB resulted in high detectability of the former in brain and the latter in CSF.

Keyword(s): Adult (MeSH) ; Animals (MeSH) ; Autoantibodies: blood (MeSH) ; Autoantibodies: cerebrospinal fluid (MeSH) ; Blood-Brain Barrier: physiopathology (MeSH) ; Brain: immunology (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Middle Aged (MeSH) ; Multiple Sclerosis: blood (MeSH) ; Multiple Sclerosis: cerebrospinal fluid (MeSH) ; Receptors, N-Methyl-D-Aspartate: immunology (MeSH) ; Seroepidemiologic Studies (MeSH) ; Autoantibodies ; NR1 NMDA receptor ; Receptors, N-Methyl-D-Aspartate

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Contributing Institute(s):

1. Translational Dementia Research Göttingen (AG Schneider Göttingen)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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