% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{CastilloGomez:138393,
      author       = {Castillo-Gomez, Esther and Kästner, Anne and Steiner,
                      Johann and Schneider, Anja and Hettling, Bilke and Poggi,
                      Giulia and Ostehr, Kristin and Uhr, Manfred and Asif, Abdul
                      R and Matzke, Mike and Schmidt, Ulrike and Pfander, Viktoria
                      and Hammer, Christian and Schulz, Thomas F and Binder, Lutz
                      and Stöcker, Winfried and Weber, Frank and Ehrenreich,
                      Hannelore},
      title        = {{T}he brain as immunoprecipitator of serum autoantibodies
                      against {N}-{M}ethyl-{D}-aspartate receptor subunit {NR}1.},
      journal      = {Annals of neurology},
      volume       = {79},
      number       = {1},
      issn         = {0364-5134},
      address      = {Hoboken, NJ},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2020-04715},
      pages        = {144-151},
      year         = {2016},
      abstract     = {Autoantibodies (AB) against N-methyl-D-aspartate receptor
                      subunit NR1 (NMDAR1) are highly seroprevalent in health and
                      disease. Symptomatic relevance may arise upon compromised
                      blood-brain barrier (BBB). However, it remained unknown
                      whether circulating NMDAR1 AB appear in the cerebrospinal
                      fluid (CSF). Of n = 271 subjects with CSF-serum pairs, 26
                      were NMDAR1 AB seropositive, but only 1 was CSF positive.
                      Contrariwise, tetanus AB (non-brain-binding) were present in
                      serum and CSF of all subjects, with CSF levels higher upon
                      BBB dysfunction. Translational mouse experiments proved the
                      hypothesis that the brain acts as an 'immunoprecipitator';
                      simultaneous injection of NMDAR1 AB and the
                      non-brain-binding green fluorescent protein AB resulted in
                      high detectability of the former in brain and the latter in
                      CSF.},
      keywords     = {Adult / Animals / Autoantibodies: blood / Autoantibodies:
                      cerebrospinal fluid / Blood-Brain Barrier: physiopathology /
                      Brain: immunology / Female / Humans / Male / Mice / Mice,
                      Inbred C57BL / Middle Aged / Multiple Sclerosis: blood /
                      Multiple Sclerosis: cerebrospinal fluid / Receptors,
                      N-Methyl-D-Aspartate: immunology / Seroepidemiologic Studies
                      / Autoantibodies (NLM Chemicals) / NR1 NMDA receptor (NLM
                      Chemicals) / Receptors, N-Methyl-D-Aspartate (NLM
                      Chemicals)},
      cin          = {AG Schneider Göttingen},
      ddc          = {610},
      cid          = {I:(DE-2719)1440011},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26505629},
      doi          = {10.1002/ana.24545},
      url          = {https://pub.dzne.de/record/138393},
}