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| 001 | 138393 | ||
| 005 | 20240826140117.0 | ||
| 024 | 7 | _ | |a 10.1002/ana.24545 |2 doi |
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| 024 | 7 | _ | |a 0364-5134 |2 ISSN |
| 024 | 7 | _ | |a 1531-8249 |2 ISSN |
| 024 | 7 | _ | |a altmetric:4680521 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-04715 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Castillo-Gomez, Esther |b 0 |
| 245 | _ | _ | |a The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1. |
| 260 | _ | _ | |a Hoboken, NJ |c 2016 |b Wiley-Blackwell |
| 264 | _ | 1 | |3 online |2 Crossref |b Wiley |c 2015-12-02 |
| 264 | _ | 1 | |3 print |2 Crossref |b Wiley |c 2016-01-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1724673655_18923 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Autoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) are highly seroprevalent in health and disease. Symptomatic relevance may arise upon compromised blood-brain barrier (BBB). However, it remained unknown whether circulating NMDAR1 AB appear in the cerebrospinal fluid (CSF). Of n = 271 subjects with CSF-serum pairs, 26 were NMDAR1 AB seropositive, but only 1 was CSF positive. Contrariwise, tetanus AB (non-brain-binding) were present in serum and CSF of all subjects, with CSF levels higher upon BBB dysfunction. Translational mouse experiments proved the hypothesis that the brain acts as an 'immunoprecipitator'; simultaneous injection of NMDAR1 AB and the non-brain-binding green fluorescent protein AB resulted in high detectability of the former in brain and the latter in CSF. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2015-09-01 |2 Crossref |u http://doi.wiley.com/10.1002/tdm_license_1.1 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Autoantibodies |2 NLM Chemicals |
| 650 | _ | 7 | |a NR1 NMDA receptor |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, N-Methyl-D-Aspartate |2 NLM Chemicals |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Autoantibodies: blood |2 MeSH |
| 650 | _ | 2 | |a Autoantibodies: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Blood-Brain Barrier: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Brain: immunology |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Multiple Sclerosis: blood |2 MeSH |
| 650 | _ | 2 | |a Multiple Sclerosis: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Receptors, N-Methyl-D-Aspartate: immunology |2 MeSH |
| 650 | _ | 2 | |a Seroepidemiologic Studies |2 MeSH |
| 700 | 1 | _ | |a Kästner, Anne |b 1 |
| 700 | 1 | _ | |a Steiner, Johann |b 2 |
| 700 | 1 | _ | |a Schneider, Anja |0 P:(DE-2719)2812035 |b 3 |u dzne |
| 700 | 1 | _ | |a Hettling, Bilke |b 4 |
| 700 | 1 | _ | |a Poggi, Giulia |b 5 |
| 700 | 1 | _ | |a Ostehr, Kristin |b 6 |
| 700 | 1 | _ | |a Uhr, Manfred |b 7 |
| 700 | 1 | _ | |a Asif, Abdul R |b 8 |
| 700 | 1 | _ | |a Matzke, Mike |b 9 |
| 700 | 1 | _ | |a Schmidt, Ulrike |b 10 |
| 700 | 1 | _ | |a Pfander, Viktoria |b 11 |
| 700 | 1 | _ | |a Hammer, Christian |b 12 |
| 700 | 1 | _ | |a Schulz, Thomas F |b 13 |
| 700 | 1 | _ | |a Binder, Lutz |b 14 |
| 700 | 1 | _ | |a Stöcker, Winfried |b 15 |
| 700 | 1 | _ | |a Weber, Frank |b 16 |
| 700 | 1 | _ | |a Ehrenreich, Hannelore |0 P:(DE-HGF)0 |b 17 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1002/ana.24545 |b : Wiley, 2015-12-02 |n 1 |p 144-151 |3 journal-article |2 Crossref |t Annals of Neurology |v 79 |y 2015 |x 0364-5134 |
| 773 | _ | _ | |a 10.1002/ana.24545 |g Vol. 79, no. 1, p. 144 - 151 |0 PERI:(DE-600)2037912-2 |n 1 |q 79:1<144 - 151 |p 144-151 |t Annals of neurology |v 79 |y 2016 |x 0364-5134 |
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