%0 Journal Article
%A Dürschmid, Stefan
%A Zaehle, Tino
%A Hinrichs, Hermann
%A Heinze, Hans-Jochen
%A Voges, Jürgen
%A Garrido, Marta I
%A Dolan, Raymond J
%A Knight, Robert T
%T Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens.
%J Cerebral cortex
%V 26
%N 3
%@ 1047-3211
%C Oxford
%I Oxford Univ. Press
%M DZNE-2020-04741
%P 1168-1175
%D 2016
%X Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental.
%K Acoustic Stimulation
%K Adult
%K Anterior Thalamic Nuclei: physiopathology
%K Auditory Perception: physiology
%K Deep Brain Stimulation
%K Drug Resistant Epilepsy: physiopathology
%K Drug Resistant Epilepsy: therapy
%K Evoked Potentials
%K Female
%K Humans
%K Male
%K Neuropsychological Tests
%K Nucleus Accumbens: physiopathology
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25576536
%2 pmc:PMC4737607
%R 10.1093/cercor/bhu304
%U https://pub.dzne.de/record/138419