Journal Article

DZNE-2020-04741

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens.

Dürschmid, S. (Corresponding author) ; Zaehle, T. ; Hinrichs, H.DZNE* ; Heinze, H.-J.DZNE* ; Voges, J.DZNE* ; Garrido, M. I. ; Dolan, R. J. ; Knight, R. T.

2016
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/cercor/bhu304

Abstract: Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental.

Keyword(s): Acoustic Stimulation (MeSH) ; Adult (MeSH) ; Anterior Thalamic Nuclei: physiopathology (MeSH) ; Auditory Perception: physiology (MeSH) ; Deep Brain Stimulation (MeSH) ; Drug Resistant Epilepsy: physiopathology (MeSH) ; Drug Resistant Epilepsy: therapy (MeSH) ; Evoked Potentials (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Neuropsychological Tests (MeSH) ; Nucleus Accumbens: physiopathology (MeSH)

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Contributing Institute(s):

1. U Clinical Researchers - Magdeburg (U Clinical Researchers - Magdeburg)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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