TY  - JOUR
AU  - Dürschmid, Stefan
AU  - Zaehle, Tino
AU  - Hinrichs, Hermann
AU  - Heinze, Hans-Jochen
AU  - Voges, Jürgen
AU  - Garrido, Marta I
AU  - Dolan, Raymond J
AU  - Knight, Robert T
TI  - Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens.
JO  - Cerebral cortex
VL  - 26
IS  - 3
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2020-04741
SP  - 1168-1175
PY  - 2016
AB  - Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental.
KW  - Acoustic Stimulation
KW  - Adult
KW  - Anterior Thalamic Nuclei: physiopathology
KW  - Auditory Perception: physiology
KW  - Deep Brain Stimulation
KW  - Drug Resistant Epilepsy: physiopathology
KW  - Drug Resistant Epilepsy: therapy
KW  - Evoked Potentials
KW  - Female
KW  - Humans
KW  - Male
KW  - Neuropsychological Tests
KW  - Nucleus Accumbens: physiopathology
LB  - PUB:(DE-HGF)16
C6  - pmid:25576536
C2  - pmc:PMC4737607
DO  - DOI:10.1093/cercor/bhu304
UR  - https://pub.dzne.de/record/138419
ER  -