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@ARTICLE{Drschmid:138419,
      author       = {Dürschmid, Stefan and Zaehle, Tino and Hinrichs, Hermann
                      and Heinze, Hans-Jochen and Voges, Jürgen and Garrido,
                      Marta I and Dolan, Raymond J and Knight, Robert T},
      title        = {{S}ensory {D}eviancy {D}etection {M}easured {D}irectly
                      {W}ithin the {H}uman {N}ucleus {A}ccumbens.},
      journal      = {Cerebral cortex},
      volume       = {26},
      number       = {3},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2020-04741},
      pages        = {1168-1175},
      year         = {2016},
      abstract     = {Rapid changes in the environment evoke a comparison between
                      expectancy and actual outcome to inform optimal subsequent
                      behavior. The nucleus accumbens (NAcc), a key interface
                      between the hippocampus and neocortical regions, is a
                      candidate region for mediating this comparison. Here, we
                      report event-related potentials obtained from the NAcc using
                      direct intracranial recordings in 5 human participants while
                      they listened to trains of auditory stimuli differing in
                      their degree of deviation from repetitive background
                      stimuli. NAcc recordings revealed an early mismatch signal
                      (50-220 ms) in response to all deviants. NAcc activity in
                      this time window was also sensitive to the statistics of
                      stimulus deviancy, with larger amplitudes as a function of
                      the level of deviancy. Importantly, this NAcc mismatch
                      signal also predicted generation of longer latency scalp
                      potentials (300-400 ms). The results provide direct human
                      evidence that the NAcc is a key component of a network
                      engaged in encoding statistics of the sensory
                      environmental.},
      keywords     = {Acoustic Stimulation / Adult / Anterior Thalamic Nuclei:
                      physiopathology / Auditory Perception: physiology / Deep
                      Brain Stimulation / Drug Resistant Epilepsy: physiopathology
                      / Drug Resistant Epilepsy: therapy / Evoked Potentials /
                      Female / Humans / Male / Neuropsychological Tests / Nucleus
                      Accumbens: physiopathology},
      cin          = {U Clinical Researchers - Magdeburg},
      ddc          = {610},
      cid          = {I:(DE-2719)7000000},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25576536},
      pmc          = {pmc:PMC4737607},
      doi          = {10.1093/cercor/bhu304},
      url          = {https://pub.dzne.de/record/138419},
}