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000138492 0247_ $$2doi$$a10.7554/eLife.09693
000138492 0247_ $$2pmid$$apmid:26623514
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000138492 037__ $$aDZNE-2020-04814
000138492 041__ $$aEnglish
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000138492 1001_ $$0P:(DE-2719)2810462$$aFarrow, Paul$$b0$$eFirst author$$udzne
000138492 245__ $$aAuxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.
000138492 260__ $$aCambridge$$beLife Sciences Publications$$c2015
000138492 264_1 $$2Crossref$$3online$$beLife Sciences Publications, Ltd$$c2015-12-01
000138492 3367_ $$2DRIVER$$aarticle
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000138492 520__ $$aAMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins-namely CKAMP39, CKAMP52 and CKAMP59-that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary subunits distinct from other families of AMPAR interacting proteins. The new members of the CKAMP family display distinct regional and developmental expression profiles in the mouse brain. Notably, despite their structural similarities they exert diverse modulation on AMPAR gating by influencing deactivation, desensitization and recovery from desensitization, as well as glutamate and cyclothiazide potency to AMPARs. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members.
000138492 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x0
000138492 542__ $$2Crossref$$i2015-12-01$$uhttp://creativecommons.org/licenses/by/4.0/
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000138492 650_7 $$2NLM Chemicals$$aBenzothiadiazines
000138492 650_7 $$2NLM Chemicals$$aCKAMP39 protein, mouse
000138492 650_7 $$2NLM Chemicals$$aCKAMP52 protein, mouse
000138492 650_7 $$2NLM Chemicals$$aCKAMP59 protein, mouse
000138492 650_7 $$2NLM Chemicals$$aCarrier Proteins
000138492 650_7 $$2NLM Chemicals$$aIntracellular Signaling Peptides and Proteins
000138492 650_7 $$2NLM Chemicals$$aMembrane Proteins
000138492 650_7 $$2NLM Chemicals$$aReceptors, AMPA
000138492 650_7 $$03KX376GY7L$$2NLM Chemicals$$aGlutamic Acid
000138492 650_7 $$0P71U09G5BW$$2NLM Chemicals$$acyclothiazide
000138492 650_2 $$2MeSH$$aAnimals
000138492 650_2 $$2MeSH$$aBenzothiadiazines: metabolism
000138492 650_2 $$2MeSH$$aBrain: embryology
000138492 650_2 $$2MeSH$$aCarrier Proteins: genetics
000138492 650_2 $$2MeSH$$aCarrier Proteins: metabolism
000138492 650_2 $$2MeSH$$aGene Expression Regulation, Developmental
000138492 650_2 $$2MeSH$$aGlutamic Acid: metabolism
000138492 650_2 $$2MeSH$$aHumans
000138492 650_2 $$2MeSH$$aIntracellular Signaling Peptides and Proteins
000138492 650_2 $$2MeSH$$aMembrane Proteins: genetics
000138492 650_2 $$2MeSH$$aMembrane Proteins: metabolism
000138492 650_2 $$2MeSH$$aMice
000138492 650_2 $$2MeSH$$aProtein Binding
000138492 650_2 $$2MeSH$$aReceptors, AMPA: agonists
000138492 650_2 $$2MeSH$$aReceptors, AMPA: metabolism
000138492 650_2 $$2MeSH$$aSequence Analysis, DNA
000138492 7001_ $$aKhodosevich, Konstantin$$b1
000138492 7001_ $$aSapir, Yechiam$$b2
000138492 7001_ $$aSchulmann, Anton$$b3
000138492 7001_ $$0P:(DE-2719)2810579$$aAslam, Muhammad$$b4$$udzne
000138492 7001_ $$aStern-Bach, Yael$$b5
000138492 7001_ $$aMonyer, Hannah$$b6
000138492 7001_ $$0P:(DE-2719)2810460$$aEngelhardt, Jakob$$b7$$eLast author$$udzne
000138492 77318 $$2Crossref$$3journal-article$$a10.7554/elife.09693$$b : eLife Sciences Publications, Ltd, 2015-12-01$$teLife$$v4$$x2050-084X$$y2015
000138492 773__ $$0PERI:(DE-600)2687154-3$$a10.7554/eLife.09693$$gVol. 4, p. e09693$$pe09693$$q4<e09693$$teLife$$v4$$x2050-084X$$y2015
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000138492 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733035
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