Journal Article

DZNE-2020-04814

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.

Farrow, P. (First author)DZNE* ; Khodosevich, K. ; Sapir, Y. ; Schulmann, A. ; Aslam, M.DZNE* ; Stern-Bach, Y. ; Monyer, H. ; Engelhardt, J. (Last author)DZNE*

2015
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: doi:10.7554/eLife.09693

Abstract: AMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins-namely CKAMP39, CKAMP52 and CKAMP59-that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary subunits distinct from other families of AMPAR interacting proteins. The new members of the CKAMP family display distinct regional and developmental expression profiles in the mouse brain. Notably, despite their structural similarities they exert diverse modulation on AMPAR gating by influencing deactivation, desensitization and recovery from desensitization, as well as glutamate and cyclothiazide potency to AMPARs. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members.

Keyword(s): Animals (MeSH) ; Benzothiadiazines: metabolism (MeSH) ; Brain: embryology (MeSH) ; Carrier Proteins: genetics (MeSH) ; Carrier Proteins: metabolism (MeSH) ; Gene Expression Regulation, Developmental (MeSH) ; Glutamic Acid: metabolism (MeSH) ; Humans (MeSH) ; Intracellular Signaling Peptides and Proteins (MeSH) ; Membrane Proteins: genetics (MeSH) ; Membrane Proteins: metabolism (MeSH) ; Mice (MeSH) ; Protein Binding (MeSH) ; Receptors, AMPA: agonists (MeSH) ; Receptors, AMPA: metabolism (MeSH) ; Sequence Analysis, DNA (MeSH) ; Benzothiadiazines ; CKAMP39 protein, mouse ; CKAMP52 protein, mouse ; CKAMP59 protein, mouse ; Carrier Proteins ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; Receptors, AMPA ; Glutamic Acid ; cyclothiazide

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Contributing Institute(s):

1. Synaptic Signalling and Neurodegeneration (AG Engelhardt)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2015

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Database coverage:
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