TY  - JOUR
AU  - Farrow, Paul
AU  - Khodosevich, Konstantin
AU  - Sapir, Yechiam
AU  - Schulmann, Anton
AU  - Aslam, Muhammad
AU  - Stern-Bach, Yael
AU  - Monyer, Hannah
AU  - Engelhardt, Jakob
TI  - Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.
JO  - eLife
VL  - 4
SN  - 2050-084X
CY  - Cambridge
PB  - eLife Sciences Publications
M1  - DZNE-2020-04814
SP  - e09693
PY  - 2015
AB  - AMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins-namely CKAMP39, CKAMP52 and CKAMP59-that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary subunits distinct from other families of AMPAR interacting proteins. The new members of the CKAMP family display distinct regional and developmental expression profiles in the mouse brain. Notably, despite their structural similarities they exert diverse modulation on AMPAR gating by influencing deactivation, desensitization and recovery from desensitization, as well as glutamate and cyclothiazide potency to AMPARs. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members.
KW  - Animals
KW  - Benzothiadiazines: metabolism
KW  - Brain: embryology
KW  - Carrier Proteins: genetics
KW  - Carrier Proteins: metabolism
KW  - Gene Expression Regulation, Developmental
KW  - Glutamic Acid: metabolism
KW  - Humans
KW  - Intracellular Signaling Peptides and Proteins
KW  - Membrane Proteins: genetics
KW  - Membrane Proteins: metabolism
KW  - Mice
KW  - Protein Binding
KW  - Receptors, AMPA: agonists
KW  - Receptors, AMPA: metabolism
KW  - Sequence Analysis, DNA
KW  - Benzothiadiazines (NLM Chemicals)
KW  - CKAMP39 protein, mouse (NLM Chemicals)
KW  - CKAMP52 protein, mouse (NLM Chemicals)
KW  - CKAMP59 protein, mouse (NLM Chemicals)
KW  - Carrier Proteins (NLM Chemicals)
KW  - Intracellular Signaling Peptides and Proteins (NLM Chemicals)
KW  - Membrane Proteins (NLM Chemicals)
KW  - Receptors, AMPA (NLM Chemicals)
KW  - Glutamic Acid (NLM Chemicals)
KW  - cyclothiazide (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26623514
C2  - pmc:PMC4733035
DO  - DOI:10.7554/eLife.09693
UR  - https://pub.dzne.de/record/138492
ER  -