TY  - JOUR
AU  - Wilke, Carlo
AU  - Gillardon, Frank
AU  - Deuschle, Christian
AU  - Dubois, Evelyn
AU  - Hobert, Markus A
AU  - Müller vom Hagen, Jennifer
AU  - Krüger, Stefanie
AU  - Biskup, Saskia
AU  - Blauwendraat, Cornelis
AU  - Hruscha, Michael
AU  - Kaeser, Stephan A
AU  - Heutink, Peter
AU  - Maetzler, Walter
AU  - Synofzik, Matthis
TI  - Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease.
JO  - Current Alzheimer research
VL  - 13
IS  - 6
SN  - 1567-2050
CY  - Hilversum
PB  - Bentham Science Publ. Ltd.
M1  - DZNE-2020-04867
SP  - 654-662
PY  - 2016
AB  - Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.
KW  - Aged
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: metabolism
KW  - Amyotrophic Lateral Sclerosis: genetics
KW  - Amyotrophic Lateral Sclerosis: metabolism
KW  - Biomarkers: blood
KW  - Biomarkers: cerebrospinal fluid
KW  - Female
KW  - Frontotemporal Dementia: genetics
KW  - Frontotemporal Dementia: metabolism
KW  - Humans
KW  - Intercellular Signaling Peptides and Proteins: blood
KW  - Intercellular Signaling Peptides and Proteins: cerebrospinal fluid
KW  - Intercellular Signaling Peptides and Proteins: genetics
KW  - Male
KW  - Middle Aged
KW  - Progranulins
KW  - Biomarkers (NLM Chemicals)
KW  - GRN protein, human (NLM Chemicals)
KW  - Intercellular Signaling Peptides and Proteins (NLM Chemicals)
KW  - Progranulins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:26971930
DO  - DOI:10.2174/1567205013666160314151247
UR  - https://pub.dzne.de/record/138545
ER  -