Journal Article

DZNE-2020-04867

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease.

Wilke, C. (First author)DZNE* ; Gillardon, F. ; Deuschle, C.DZNE* ; Dubois, E.DZNE* ; Hobert, M. A.DZNE* ; Müller vom Hagen, J.DZNE* ; Krüger, S. ; Biskup, S. ; Blauwendraat, C.DZNE* ; Hruscha, M.DZNE* ; Kaeser, S. A.DZNE* ; Heutink, P.DZNE* ; Maetzler, W.DZNE* ; Synofzik, M. (Last author)DZNE*

2016
Bentham Science Publ. Ltd. Hilversum

This record in other databases:    

Please use a persistent id in citations: doi:10.2174/1567205013666160314151247

Abstract: Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.

Keyword(s): Aged (MeSH) ; Alzheimer Disease: genetics (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Amyotrophic Lateral Sclerosis: genetics (MeSH) ; Amyotrophic Lateral Sclerosis: metabolism (MeSH) ; Biomarkers: blood (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Female (MeSH) ; Frontotemporal Dementia: genetics (MeSH) ; Frontotemporal Dementia: metabolism (MeSH) ; Humans (MeSH) ; Intercellular Signaling Peptides and Proteins: blood (MeSH) ; Intercellular Signaling Peptides and Proteins: cerebrospinal fluid (MeSH) ; Intercellular Signaling Peptides and Proteins: genetics (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Progranulins (MeSH) ; Biomarkers ; GRN protein, human ; Intercellular Signaling Peptides and Proteins ; Progranulins

---

Contributing Institute(s):

1. Core ICRU (Core ICRU)
2. Parkinson Genetics (AG Gasser 1)
3. Tübingen Pre 2020 (Tübingen Pre 2020)
4. Ext UKT TREND Studie (Ext UKT-Trend)
5. Genome Biology of Neurodegenerative Diseases (AG Heutink 1)
6. Cell Biology of Neurologic Diseases (AG Jucker)
7. Functional Neurogeriatrics (AG Maetzler)

Research Program(s):

1. 345 - Population Studies and Genetics (POF3-345) (POF3-345)
2. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
3. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2016

---

Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---