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@ARTICLE{Wilke:138545,
      author       = {Wilke, Carlo and Gillardon, Frank and Deuschle, Christian
                      and Dubois, Evelyn and Hobert, Markus A and Müller vom
                      Hagen, Jennifer and Krüger, Stefanie and Biskup, Saskia and
                      Blauwendraat, Cornelis and Hruscha, Michael and Kaeser,
                      Stephan A and Heutink, Peter and Maetzler, Walter and
                      Synofzik, Matthis},
      title        = {{S}erum {L}evels of {P}rogranulin {D}o {N}ot {R}eflect
                      {C}erebrospinal {F}luid {L}evels in {N}eurodegenerative
                      {D}isease.},
      journal      = {Current Alzheimer research},
      volume       = {13},
      number       = {6},
      issn         = {1567-2050},
      address      = {Hilversum},
      publisher    = {Bentham Science Publ. Ltd.},
      reportid     = {DZNE-2020-04867},
      pages        = {654-662},
      year         = {2016},
      abstract     = {Altered progranulin levels play a major role in
                      neurodegenerative diseases, like Alzheimer's dementia (AD),
                      frontotemporal dementia (FTD) and amyotrophic lateral
                      sclerosis (ALS), even in the absence of GRN mutations.
                      Increasing progranulin levels could hereby provide a novel
                      treatment strategy. However, knowledge on progranulin
                      regulation in neurodegenerative diseases remains limited. We
                      here demonstrate that cerebrospinal fluid progranulin levels
                      do not correlate with its serum levels in AD, FTD and ALS,
                      indicating a differential regulation of its central and
                      peripheral levels in neurodegeneration. Blood progranulin
                      levels thus do not reliably predict central nervous
                      progranulin levels and their response to future
                      progranulin-increasing therapeutics.},
      keywords     = {Aged / Alzheimer Disease: genetics / Alzheimer Disease:
                      metabolism / Amyotrophic Lateral Sclerosis: genetics /
                      Amyotrophic Lateral Sclerosis: metabolism / Biomarkers:
                      blood / Biomarkers: cerebrospinal fluid / Female /
                      Frontotemporal Dementia: genetics / Frontotemporal Dementia:
                      metabolism / Humans / Intercellular Signaling Peptides and
                      Proteins: blood / Intercellular Signaling Peptides and
                      Proteins: cerebrospinal fluid / Intercellular Signaling
                      Peptides and Proteins: genetics / Male / Middle Aged /
                      Progranulins / Biomarkers (NLM Chemicals) / GRN protein,
                      human (NLM Chemicals) / Intercellular Signaling Peptides and
                      Proteins (NLM Chemicals) / Progranulins (NLM Chemicals)},
      cin          = {Core ICRU / AG Gasser 1 / Tübingen Pre 2020 / Ext
                      UKT-Trend / AG Heutink 1 / AG Jucker / AG Maetzler},
      ddc          = {610},
      cid          = {I:(DE-2719)1240005 / I:(DE-2719)1210000 /
                      I:(DE-2719)6000018 / I:(DE-2719)5000056 / I:(DE-2719)1210002
                      / I:(DE-2719)1210001 / I:(DE-2719)5000024},
      pnm          = {345 - Population Studies and Genetics (POF3-345) / 342 -
                      Disease Mechanisms and Model Systems (POF3-342) / 344 -
                      Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-345 / G:(DE-HGF)POF3-342 /
                      G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26971930},
      doi          = {10.2174/1567205013666160314151247},
      url          = {https://pub.dzne.de/record/138545},
}