Home > Publications Database > Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease. > print

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024 7 _ |a 10.2174/1567205013666160314151247
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024 7 _ |a 1567-2050
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024 7 _ |a 1875-5828
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100 1 _ |a Wilke, Carlo
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245 _ _ |a Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease.
260 _ _ |a Hilversum
|c 2016
|b Bentham Science Publ. Ltd.
264 _ 1 |3 print
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|b Bentham Science Publishers Ltd.
|c 2016-04-15
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520 _ _ |a Altered progranulin levels play a major role in neurodegenerative diseases, like Alzheimer's dementia (AD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), even in the absence of GRN mutations. Increasing progranulin levels could hereby provide a novel treatment strategy. However, knowledge on progranulin regulation in neurodegenerative diseases remains limited. We here demonstrate that cerebrospinal fluid progranulin levels do not correlate with its serum levels in AD, FTD and ALS, indicating a differential regulation of its central and peripheral levels in neurodegeneration. Blood progranulin levels thus do not reliably predict central nervous progranulin levels and their response to future progranulin-increasing therapeutics.
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650 _ 7 |a Biomarkers
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650 _ 7 |a GRN protein, human
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650 _ 7 |a Intercellular Signaling Peptides and Proteins
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650 _ 7 |a Progranulins
|2 NLM Chemicals
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Alzheimer Disease: genetics
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: genetics
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: metabolism
|2 MeSH
650 _ 2 |a Biomarkers: blood
|2 MeSH
650 _ 2 |a Biomarkers: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: genetics
|2 MeSH
650 _ 2 |a Frontotemporal Dementia: metabolism
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Intercellular Signaling Peptides and Proteins: blood
|2 MeSH
650 _ 2 |a Intercellular Signaling Peptides and Proteins: cerebrospinal fluid
|2 MeSH
650 _ 2 |a Intercellular Signaling Peptides and Proteins: genetics
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Progranulins
|2 MeSH
700 1 _ |a Gillardon, Frank
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700 1 _ |a Deuschle, Christian
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700 1 _ |a Dubois, Evelyn
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700 1 _ |a Hobert, Markus A
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700 1 _ |a Müller vom Hagen, Jennifer
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700 1 _ |a Krüger, Stefanie
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700 1 _ |a Biskup, Saskia
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700 1 _ |a Blauwendraat, Cornelis
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700 1 _ |a Hruscha, Michael
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700 1 _ |a Kaeser, Stephan A
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700 1 _ |a Heutink, Peter
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700 1 _ |a Maetzler, Walter
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700 1 _ |a Synofzik, Matthis
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773 1 8 |a 10.2174/1567205013666160314151247
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