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000138745 0247_ $$2doi$$a10.1126/science.aaf4238
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000138745 0247_ $$2ISSN$$a0036-8075
000138745 0247_ $$2ISSN$$a1095-9203
000138745 0247_ $$2ISSN$$a1947-8062
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000138745 037__ $$aDZNE-2020-05067
000138745 041__ $$aEnglish
000138745 082__ $$a320
000138745 1001_ $$0P:(DE-HGF)0$$aMass, Elvira$$b0
000138745 245__ $$aSpecification of tissue-resident macrophages during organogenesis.
000138745 260__ $$aWashington, DC$$bAssoc.60841$$c2016
000138745 264_1 $$2Crossref$$3online$$bAmerican Association for the Advancement of Science (AAAS)$$c2016-08-04
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000138745 520__ $$aTissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor-dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis, as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues.
000138745 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000138745 536__ $$0G:(DE-HGF)POF3-341$$a341 - Molecular Signaling (POF3-341)$$cPOF3-341$$fPOF III$$x1
000138745 542__ $$2Crossref$$i2017-09-09$$uhttp://www.sciencemag.org/about/science-licenses-journal-article-reuse
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000138745 650_7 $$2NLM Chemicals$$aCX3C Chemokine Receptor 1
000138745 650_7 $$2NLM Chemicals$$aCx3cr1 protein, mouse
000138745 650_7 $$2NLM Chemicals$$aInhibitor of Differentiation Proteins
000138745 650_7 $$2NLM Chemicals$$aReceptors, Chemokine
000138745 650_7 $$0135845-89-5$$2NLM Chemicals$$aIdb3 protein, mouse
000138745 650_2 $$2MeSH$$aAnimals
000138745 650_2 $$2MeSH$$aCX3C Chemokine Receptor 1
000138745 650_2 $$2MeSH$$aCell Differentiation: genetics
000138745 650_2 $$2MeSH$$aEmbryo, Mammalian: cytology
000138745 650_2 $$2MeSH$$aEmbryonic Development
000138745 650_2 $$2MeSH$$aEmbryonic Induction
000138745 650_2 $$2MeSH$$aErythroid Precursor Cells: cytology
000138745 650_2 $$2MeSH$$aErythroid Precursor Cells: metabolism
000138745 650_2 $$2MeSH$$aFemale
000138745 650_2 $$2MeSH$$aGene Expression Regulation, Developmental
000138745 650_2 $$2MeSH$$aHematopoiesis: genetics
000138745 650_2 $$2MeSH$$aHematopoiesis: physiology
000138745 650_2 $$2MeSH$$aInhibitor of Differentiation Proteins: metabolism
000138745 650_2 $$2MeSH$$aKupffer Cells: cytology
000138745 650_2 $$2MeSH$$aKupffer Cells: metabolism
000138745 650_2 $$2MeSH$$aMacrophages: cytology
000138745 650_2 $$2MeSH$$aMacrophages: metabolism
000138745 650_2 $$2MeSH$$aMice
000138745 650_2 $$2MeSH$$aMice, Mutant Strains
000138745 650_2 $$2MeSH$$aMyeloid Progenitor Cells: cytology
000138745 650_2 $$2MeSH$$aMyeloid Progenitor Cells: metabolism
000138745 650_2 $$2MeSH$$aOrgan Specificity
000138745 650_2 $$2MeSH$$aOrganogenesis
000138745 650_2 $$2MeSH$$aReceptors, Chemokine: genetics
000138745 650_2 $$2MeSH$$aTranscriptome
000138745 693__ $$0EXP:(DE-2719)PRECISE-20190321$$5EXP:(DE-2719)PRECISE-20190321$$ePlatform for Single Cell Genomics and Epigenomics at DZNE  University of Bonn$$x0
000138745 7001_ $$0P:(DE-HGF)0$$aBallesteros, Ivan$$b1
000138745 7001_ $$0P:(DE-HGF)0$$aFarlik, Matthias$$b2
000138745 7001_ $$0P:(DE-HGF)0$$aHalbritter, Florian$$b3
000138745 7001_ $$0P:(DE-HGF)0$$aGünther, Patrick$$b4
000138745 7001_ $$0P:(DE-HGF)0$$aCrozet, Lucile$$b5
000138745 7001_ $$0P:(DE-HGF)0$$aJacome-Galarza, Christian E$$b6
000138745 7001_ $$0P:(DE-HGF)0$$aHändler, Kristian$$b7
000138745 7001_ $$0P:(DE-HGF)0$$aKlughammer, Johanna$$b8
000138745 7001_ $$0P:(DE-HGF)0$$aKobayashi, Yasuhiro$$b9
000138745 7001_ $$0P:(DE-HGF)0$$aGomez-Perdiguero, Elisa$$b10
000138745 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b11$$udzne
000138745 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc$$b12$$udzne
000138745 7001_ $$0P:(DE-HGF)0$$aBock, Christoph$$b13
000138745 7001_ $$0P:(DE-HGF)0$$aGeissmann, Frederic$$b14$$eCorresponding author
000138745 77318 $$2Crossref$$3journal-article$$a10.1126/science.aaf4238$$b : American Association for the Advancement of Science (AAAS), 2016-08-04$$n6304$$paaf4238-aaf4238$$tScience$$v353$$x0036-8075$$y2016
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000138745 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066309
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000138745 9141_ $$y2016
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