Journal Article

DZNE-2020-05067

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Specification of tissue-resident macrophages during organogenesis.

Mass, E. ; Ballesteros, I. ; Farlik, M. ; Halbritter, F. ; Günther, P. ; Crozet, L. ; Jacome-Galarza, C. E. ; Händler, K. ; Klughammer, J. ; Kobayashi, Y. ; Gomez-Perdiguero, E. ; Schultze, J. L.DZNE* ; Beyer, M.DZNE* ; Bock, C. ; Geissmann, F. (Corresponding author)

2016
Assoc.60841 Washington, DC

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Please use a persistent id in citations: doi:10.1126/science.aaf4238

Abstract: Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor-dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis, as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues.

Keyword(s): Animals (MeSH) ; CX3C Chemokine Receptor 1 (MeSH) ; Cell Differentiation: genetics (MeSH) ; Embryo, Mammalian: cytology (MeSH) ; Embryonic Development (MeSH) ; Embryonic Induction (MeSH) ; Erythroid Precursor Cells: cytology (MeSH) ; Erythroid Precursor Cells: metabolism (MeSH) ; Female (MeSH) ; Gene Expression Regulation, Developmental (MeSH) ; Hematopoiesis: genetics (MeSH) ; Hematopoiesis: physiology (MeSH) ; Inhibitor of Differentiation Proteins: metabolism (MeSH) ; Kupffer Cells: cytology (MeSH) ; Kupffer Cells: metabolism (MeSH) ; Macrophages: cytology (MeSH) ; Macrophages: metabolism (MeSH) ; Mice (MeSH) ; Mice, Mutant Strains (MeSH) ; Myeloid Progenitor Cells: cytology (MeSH) ; Myeloid Progenitor Cells: metabolism (MeSH) ; Organ Specificity (MeSH) ; Organogenesis (MeSH) ; Receptors, Chemokine: genetics (MeSH) ; Transcriptome (MeSH) ; CX3C Chemokine Receptor 1 ; Cx3cr1 protein, mouse ; Inhibitor of Differentiation Proteins ; Receptors, Chemokine ; Idb3 protein, mouse

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Contributing Institute(s):

1. United epigenomic platform (Schultze - PRECISE)
2. Molecular Immunology in Neurodegeneration (AG Beyer)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
2. 341 - Molecular Signaling (POF3-341) (POF3-341)

Experiment(s):

1. Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF >= 40 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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