TY  - JOUR
AU  - Mass, Elvira
AU  - Ballesteros, Ivan
AU  - Farlik, Matthias
AU  - Halbritter, Florian
AU  - Günther, Patrick
AU  - Crozet, Lucile
AU  - Jacome-Galarza, Christian E
AU  - Händler, Kristian
AU  - Klughammer, Johanna
AU  - Kobayashi, Yasuhiro
AU  - Gomez-Perdiguero, Elisa
AU  - Schultze, Joachim L
AU  - Beyer, Marc
AU  - Bock, Christoph
AU  - Geissmann, Frederic
TI  - Specification of tissue-resident macrophages during organogenesis.
JO  - Science / Science now
VL  - 353
IS  - 6304
SN  - 0036-8075
CY  - Washington, DC
PB  - Assoc.60841
M1  - DZNE-2020-05067
SP  - aaf4238-aaf4238
PY  - 2016
AB  - Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor-dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis, as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues.
KW  - Animals
KW  - CX3C Chemokine Receptor 1
KW  - Cell Differentiation: genetics
KW  - Embryo, Mammalian: cytology
KW  - Embryonic Development
KW  - Embryonic Induction
KW  - Erythroid Precursor Cells: cytology
KW  - Erythroid Precursor Cells: metabolism
KW  - Female
KW  - Gene Expression Regulation, Developmental
KW  - Hematopoiesis: genetics
KW  - Hematopoiesis: physiology
KW  - Inhibitor of Differentiation Proteins: metabolism
KW  - Kupffer Cells: cytology
KW  - Kupffer Cells: metabolism
KW  - Macrophages: cytology
KW  - Macrophages: metabolism
KW  - Mice
KW  - Mice, Mutant Strains
KW  - Myeloid Progenitor Cells: cytology
KW  - Myeloid Progenitor Cells: metabolism
KW  - Organ Specificity
KW  - Organogenesis
KW  - Receptors, Chemokine: genetics
KW  - Transcriptome
KW  - CX3C Chemokine Receptor 1 (NLM Chemicals)
KW  - Cx3cr1 protein, mouse (NLM Chemicals)
KW  - Inhibitor of Differentiation Proteins (NLM Chemicals)
KW  - Receptors, Chemokine (NLM Chemicals)
KW  - Idb3 protein, mouse (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27492475
C2  - pmc:PMC5066309
DO  - DOI:10.1126/science.aaf4238
UR  - https://pub.dzne.de/record/138745
ER  -