% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Mass:138745,
      author       = {Mass, Elvira and Ballesteros, Ivan and Farlik, Matthias and
                      Halbritter, Florian and Günther, Patrick and Crozet, Lucile
                      and Jacome-Galarza, Christian E and Händler, Kristian and
                      Klughammer, Johanna and Kobayashi, Yasuhiro and
                      Gomez-Perdiguero, Elisa and Schultze, Joachim L and Beyer,
                      Marc and Bock, Christoph and Geissmann, Frederic},
      title        = {{S}pecification of tissue-resident macrophages during
                      organogenesis.},
      journal      = {Science / Science now},
      volume       = {353},
      number       = {6304},
      issn         = {0036-8075},
      address      = {Washington, DC},
      publisher    = {Assoc.60841},
      reportid     = {DZNE-2020-05067},
      pages        = {aaf4238-aaf4238},
      year         = {2016},
      abstract     = {Tissue-resident macrophages support embryonic development
                      and tissue homeostasis and repair. The mechanisms that
                      control their differentiation remain unclear. We report here
                      that erythro-myeloid progenitors in mice generate
                      premacrophages (pMacs) that simultaneously colonize the
                      whole embryo from embryonic day 9.5 in a
                      chemokine-receptor-dependent manner. The core macrophage
                      program initiated in pMacs is rapidly diversified as
                      expression of transcriptional regulators becomes
                      tissue-specific in early macrophages. This process appears
                      essential for macrophage specification and maintenance, as
                      inactivation of Id3 impairs the development of liver
                      macrophages and results in selective Kupffer cell deficiency
                      in adults. We propose that macrophage differentiation is an
                      integral part of organogenesis, as colonization of organ
                      anlagen by pMacs is followed by their specification into
                      tissue macrophages, hereby generating the macrophage
                      diversity observed in postnatal tissues.},
      keywords     = {Animals / CX3C Chemokine Receptor 1 / Cell Differentiation:
                      genetics / Embryo, Mammalian: cytology / Embryonic
                      Development / Embryonic Induction / Erythroid Precursor
                      Cells: cytology / Erythroid Precursor Cells: metabolism /
                      Female / Gene Expression Regulation, Developmental /
                      Hematopoiesis: genetics / Hematopoiesis: physiology /
                      Inhibitor of Differentiation Proteins: metabolism / Kupffer
                      Cells: cytology / Kupffer Cells: metabolism / Macrophages:
                      cytology / Macrophages: metabolism / Mice / Mice, Mutant
                      Strains / Myeloid Progenitor Cells: cytology / Myeloid
                      Progenitor Cells: metabolism / Organ Specificity /
                      Organogenesis / Receptors, Chemokine: genetics /
                      Transcriptome / CX3C Chemokine Receptor 1 (NLM Chemicals) /
                      Cx3cr1 protein, mouse (NLM Chemicals) / Inhibitor of
                      Differentiation Proteins (NLM Chemicals) / Receptors,
                      Chemokine (NLM Chemicals) / Idb3 protein, mouse (NLM
                      Chemicals)},
      cin          = {Schultze - PRECISE / AG Beyer},
      ddc          = {320},
      cid          = {I:(DE-2719)1013031 / I:(DE-2719)1013035},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 341
                      - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-341},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27492475},
      pmc          = {pmc:PMC5066309},
      doi          = {10.1126/science.aaf4238},
      url          = {https://pub.dzne.de/record/138745},
}