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| 001 | 138745 | ||
| 005 | 20240321220506.0 | ||
| 024 | 7 | _ | |a 10.1126/science.aaf4238 |2 doi |
| 024 | 7 | _ | |a pmid:27492475 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5066309 |2 pmc |
| 024 | 7 | _ | |a 0036-8075 |2 ISSN |
| 024 | 7 | _ | |a 1095-9203 |2 ISSN |
| 024 | 7 | _ | |a 1947-8062 |2 ISSN |
| 024 | 7 | _ | |a altmetric:10270189 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05067 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 320 |
| 100 | 1 | _ | |a Mass, Elvira |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Specification of tissue-resident macrophages during organogenesis. |
| 260 | _ | _ | |a Washington, DC |c 2016 |b Assoc.60841 |
| 264 | _ | 1 | |3 online |2 Crossref |b American Association for the Advancement of Science (AAAS) |c 2016-08-04 |
| 264 | _ | 1 | |3 print |2 Crossref |b American Association for the Advancement of Science (AAAS) |c 2016-09-09 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1586257431_6464 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor-dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in early macrophages. This process appears essential for macrophage specification and maintenance, as inactivation of Id3 impairs the development of liver macrophages and results in selective Kupffer cell deficiency in adults. We propose that macrophage differentiation is an integral part of organogenesis, as colonization of organ anlagen by pMacs is followed by their specification into tissue macrophages, hereby generating the macrophage diversity observed in postnatal tissues. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 1 |
| 542 | _ | _ | |i 2017-09-09 |2 Crossref |u http://www.sciencemag.org/about/science-licenses-journal-article-reuse |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a CX3C Chemokine Receptor 1 |2 NLM Chemicals |
| 650 | _ | 7 | |a Cx3cr1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Inhibitor of Differentiation Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, Chemokine |2 NLM Chemicals |
| 650 | _ | 7 | |a Idb3 protein, mouse |0 135845-89-5 |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a CX3C Chemokine Receptor 1 |2 MeSH |
| 650 | _ | 2 | |a Cell Differentiation: genetics |2 MeSH |
| 650 | _ | 2 | |a Embryo, Mammalian: cytology |2 MeSH |
| 650 | _ | 2 | |a Embryonic Development |2 MeSH |
| 650 | _ | 2 | |a Embryonic Induction |2 MeSH |
| 650 | _ | 2 | |a Erythroid Precursor Cells: cytology |2 MeSH |
| 650 | _ | 2 | |a Erythroid Precursor Cells: metabolism |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Gene Expression Regulation, Developmental |2 MeSH |
| 650 | _ | 2 | |a Hematopoiesis: genetics |2 MeSH |
| 650 | _ | 2 | |a Hematopoiesis: physiology |2 MeSH |
| 650 | _ | 2 | |a Inhibitor of Differentiation Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Kupffer Cells: cytology |2 MeSH |
| 650 | _ | 2 | |a Kupffer Cells: metabolism |2 MeSH |
| 650 | _ | 2 | |a Macrophages: cytology |2 MeSH |
| 650 | _ | 2 | |a Macrophages: metabolism |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Mutant Strains |2 MeSH |
| 650 | _ | 2 | |a Myeloid Progenitor Cells: cytology |2 MeSH |
| 650 | _ | 2 | |a Myeloid Progenitor Cells: metabolism |2 MeSH |
| 650 | _ | 2 | |a Organ Specificity |2 MeSH |
| 650 | _ | 2 | |a Organogenesis |2 MeSH |
| 650 | _ | 2 | |a Receptors, Chemokine: genetics |2 MeSH |
| 650 | _ | 2 | |a Transcriptome |2 MeSH |
| 693 | _ | _ | |0 EXP:(DE-2719)PRECISE-20190321 |5 EXP:(DE-2719)PRECISE-20190321 |e Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn |x 0 |
| 700 | 1 | _ | |a Ballesteros, Ivan |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Farlik, Matthias |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Halbritter, Florian |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Günther, Patrick |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Crozet, Lucile |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Jacome-Galarza, Christian E |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Händler, Kristian |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Klughammer, Johanna |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Kobayashi, Yasuhiro |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Gomez-Perdiguero, Elisa |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Schultze, Joachim L |0 P:(DE-2719)2811660 |b 11 |u dzne |
| 700 | 1 | _ | |a Beyer, Marc |0 P:(DE-2719)2812219 |b 12 |u dzne |
| 700 | 1 | _ | |a Bock, Christoph |0 P:(DE-HGF)0 |b 13 |
| 700 | 1 | _ | |a Geissmann, Frederic |0 P:(DE-HGF)0 |b 14 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1126/science.aaf4238 |b : American Association for the Advancement of Science (AAAS), 2016-08-04 |n 6304 |p aaf4238-aaf4238 |3 journal-article |2 Crossref |t Science |v 353 |y 2016 |x 0036-8075 |
| 773 | _ | _ | |a 10.1126/science.aaf4238 |g Vol. 353, no. 6304, p. aaf4238 - aaf4238 |0 PERI:(DE-600)2089761-3 |n 6304 |q 353:6304 |t Science / Science now |v 353 |y 2016 |x 0036-8075 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066309 |
| 909 | C | O | |o oai:pub.dzne.de:138745 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 11 |6 P:(DE-2719)2811660 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 12 |6 P:(DE-2719)2812219 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |2 G:(DE-HGF)POF3-300 |v Disease Mechanisms and Model Systems |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |2 G:(DE-HGF)POF3-300 |v Molecular Signaling |x 1 |
| 914 | 1 | _ | |y 2016 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
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| 915 | _ | _ | |a No Peer Review |0 StatID:(DE-HGF)0020 |2 StatID |b ASC |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b SCIENCE : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
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| 980 | _ | _ | |a I:(DE-2719)5000031 |
| 980 | _ | _ | |a I:(DE-2719)1013035 |
| 980 | _ | _ | |a UNRESTRICTED |
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