Journal Article

DZNE-2020-05115

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Subtypes of mild cognitive impairment in patients with Parkinson's disease: evidence from the LANDSCAPE study.

Kalbe, E. (Corresponding author) ; Rehberg, S. P. ; Heber, I. ; Kronenbuerger, M. ; Schulz, J. B. ; Storch, A. ; Linse, K. ; Schneider, C. ; Gräber, S.DZNE* ; Liepelt-Scarfone, I.DZNE* ; Berg, D.DZNE* ; Dams, J. ; Balzer-Geldsetzer, M. ; Hilker, R. ; Oberschmidt, C. ; Witt, K. ; Schmidt, N. ; Mollenhauer, B. ; Trenkwalder, C. ; Spottke, A.DZNE* ; Röske, S.DZNE* ; Wittchen, H.-U. ; Riedel, O. ; Dodel, R.

2016
BMJ Publishing Group London

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Please use a persistent id in citations: doi:10.1136/jnnp-2016-313838

Abstract: Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI.Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed.269 patients with PD-MCI (age 67.8±7.4, Unified Parkinson's Disease Rating Scale (UPDRS-III) scores 23.2±11.6) were included. PD-MCI subtypes were 39.4% non-amnestic single domain, 30.5% amnestic multiple domain, 23.4% non-amnestic multiple domain and 6.7% amnestic single domain. Executive functions were most frequently impaired. The most sensitive tests to detect cognitive dysfunctions were the Modified Card Sorting Test, digit span backwards and word list learning direct recall. Multiple stepwise regression analyses showed that global cognition, gender and age, but not education or disease-related parameters predicted PD-MCI subtypes.This study with the so far largest number of prospectively recruited patients with PD-MCI indicates that non-amnestic PD-MCI is more frequent than amnestic PD-MCI; executive dysfunctions are the most typical cognitive symptom in PD-MCI; and age, gender and global cognition predict the PD-MCI subtype. Longitudinal data are needed to test the hypothesis that patients with PD-MCI with specific cognitive profiles have different risks to develop dementia.

Keyword(s): Aged (MeSH) ; Amnesia: classification (MeSH) ; Amnesia: diagnosis (MeSH) ; Amnesia: epidemiology (MeSH) ; Amnesia: psychology (MeSH) ; Cognitive Dysfunction: classification (MeSH) ; Cognitive Dysfunction: diagnosis (MeSH) ; Cognitive Dysfunction: epidemiology (MeSH) ; Cognitive Dysfunction: psychology (MeSH) ; Cross-Sectional Studies (MeSH) ; Executive Function (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Neuropsychological Tests (MeSH) ; Parkinson Disease: classification (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Parkinson Disease: epidemiology (MeSH) ; Parkinson Disease: psychology (MeSH) ; Prospective Studies (MeSH)

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Contributing Institute(s):

1. Core ICRU (Core ICRU)
2. Parkinson Genetics (AG Gasser 1)
3. Parkinson's Disease Genetics AG Berg (AG Berg)
4. Patient studies (Patient studies, Bonn)
5. Neuropsychology (AG Wagner)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2016

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Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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