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| Home > Publications Database > Stromal Cell-Derived Factor-1 Alpha Is Decreased in Women With Migraine With Aura. |
| Home > Publications Database > Stromal Cell-Derived Factor-1 Alpha Is Decreased in Women With Migraine With Aura. |
| Journal Article | DZNE-2020-05205 |
; ; ; ;
2016
Wiley-Blackwell
Oxford [u.a.]
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Please use a persistent id in citations: doi:10.1111/head.12839
Abstract: Endothelial dysfunction may contribute to the pathophysiology of migraine with aura. Stromal cell-derived factor-1 alpha (SDF-1α) is involved in the maintenance of endothelial integrity via mobilization of vascular stem cells.We sought to determine whether SDF-1α levels are decreased in women with MA.In this post hoc analysis of a case-cohort study, levels of SDF-1α were determined by enzyme-linked immunosorbent assay. Endothelial function was assessed using peripheral arterial tonometry. Arterial stiffness was assessed by fingertip tonometry derived and heart-rate-adjusted augmentation index (AI).Twenty-eight women with MA and 27 age-matched healthy women were included in this study. Levels of SDF-1α were significantly lower in women with MA compared to age- and risk factor-matched healthy women (1763 ± 281 vs 2013 ± 263 pg/mL, P = 0.006). SDF-1α levels were positively correlated with AI in healthy women (r = 0.49, P = 0.009), but not in women with MA (r = 0.05, P = 0.78). SDF-1α levels were negatively correlated with CD144-positive endothelial microparticles (EMP; r = -0.31, P = .02), and activated CD62E-positive EMP (r = -0.35, P = .01).Levels of SDF-1α are decreased in women with MA and are associated with EMPs as a surrogate marker of endothelial dysfunction. This might contribute to the pathophysiology and vascular risk in MA, but evidence from larger prospective studies is warranted.
Keyword(s): Adult (MeSH) ; Arteries: physiopathology (MeSH) ; Biomarkers: metabolism (MeSH) ; Chemokine CXCL12: metabolism (MeSH) ; Cohort Studies (MeSH) ; Enzyme-Linked Immunosorbent Assay (MeSH) ; Female (MeSH) ; Fingers: blood supply (MeSH) ; Fingers: physiopathology (MeSH) ; Humans (MeSH) ; Manometry (MeSH) ; Migraine with Aura: metabolism (MeSH) ; Vascular Stiffness: physiology (MeSH) ; Biomarkers ; CXCL12 protein, human ; Chemokine CXCL12
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